Detailed view for TcCLB.510571.30
Basic information
TDR Targets ID: 48177
Trypanosoma cruzi, actin 1, putative
Source Database / ID: TriTrypDB GeneDB
Trypanosoma cruzi, actin 1, putative
Source Database / ID: TriTrypDB GeneDB
pI: 5.462 |
Length (AA): 376 |
MW (Da): 41968 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00022
Actin
Gene Ontology
Mouse over links to read term descriptions.
GO:0005515
protein binding Metabolic Pathways
Cell Communication (KEGG)
Structural information
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 5 | 376 | 1yag (A) | 4 | 375 | 72.00 | 0 | 1 | 1.92 | -1.71 |
| 1 | 288 | 4b1y (B) | 88 | 375 | 70.00 | 0 | 1 | 1.922 | -1.33 |
| 1 | 288 | 5i9e (D) | 88 | 375 | 73.00 | 0 | 1 | 1.825 | -0.76 |
| 2 | 376 | 4b1y (B) | 1 | 375 | 71.00 | 0 | 1 | 1.86014 | -1.07 |
| 4 | 368 | 4cbu (A) | 4 | 368 | 75.00 | 0 | 1 | 1.91554 | -1.24 |
| 6 | 376 | 5i9e (D) | 5 | 375 | 75.00 | 0 | 1 | 1.8175 | -0.95 |
| 7 | 376 | 5i9e (B) | 6 | 375 | 59.00 | 0 | 1 | 1.62584 | -0.22 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126595)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT3G12110 | actin-11 |
| Arabidopsis thaliana | AT3G53750 | actin 3 |
| Arabidopsis thaliana | AT1G49240 | actin 8 |
| Arabidopsis thaliana | AT5G09810 | actin 7 |
| Arabidopsis thaliana | AT3G46520 | actin-12 |
| Arabidopsis thaliana | AT3G18780 | actin 2 |
| Arabidopsis thaliana | AT2G42100 | Actin-like ATPase superfamily protein |
| Arabidopsis thaliana | AT2G37620 | actin 1 |
| Arabidopsis thaliana | AT5G59370 | actin 4 |
| Babesia bovis | BBOV_I000300 | actin |
| Brugia malayi | Bm1_34925 | actin 1 |
| Brugia malayi | Bm1_34930 | actin 2 |
| Brugia malayi | Bm1_21725 | actin 2 |
| Brugia malayi | Bm1_16810 | actin |
| Brugia malayi | Bm1_21705 | actin 1 |
| Candida albicans | CaO19.5007 | Actin |
| Candida albicans | CaO19.12474 | Actin |
| Caenorhabditis elegans | CELE_T25C8.2 | Protein ACT-5 |
| Caenorhabditis elegans | CELE_T04C12.5 | Protein ACT-2 |
| Caenorhabditis elegans | CELE_T04C12.4 | Protein ACT-3 |
| Caenorhabditis elegans | CELE_M03F4.2 | Protein ACT-4, isoform B |
| Caenorhabditis elegans | CELE_T04C12.6 | Protein ACT-1 |
| Cryptosporidium hominis | Chro.50056 | actin |
| Cryptosporidium parvum | cgd5_3160 | actin |
| Dictyostelium discoideum | DDB_G0274133 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274599 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274129 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0272520 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274561 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274137 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0288879 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0272248 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0289553 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0269234 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274135 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0289811 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0289005 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0275023 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0280545 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274131 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0289505 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0289487 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0268744 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274601 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0289489 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274285 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0274727 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0289663 | hypothetical protein |
| Drosophila melanogaster | Dmel_CG4027 | Actin 5C |
| Drosophila melanogaster | Dmel_CG18290 | Actin 87E |
| Drosophila melanogaster | Dmel_CG12051 | Actin 42A |
| Drosophila melanogaster | Dmel_CG10067 | Actin 57B |
| Drosophila melanogaster | Dmel_CG7478 | Actin 79B |
| Drosophila melanogaster | Dmel_CG5178 | Actin 88F |
| Echinococcus granulosus | EgrG_000703300 | actin |
| Echinococcus granulosus | EgrG_000701700 | actin |
| Echinococcus granulosus | EgrG_000061200 | actin |
| Echinococcus granulosus | EgrG_002050500 | actin |
| Echinococcus granulosus | EgrG_000406900 | Actin cytoplasmic A3 |
| Echinococcus granulosus | EgrG_000928900 | actin cytoplasmic |
| Echinococcus granulosus | EgrG_002050100 | actin |
| Echinococcus granulosus | EgrG_000916000 | actin |
| Echinococcus granulosus | EgrG_000190400 | actin cytoplasmic type 5 |
| Echinococcus granulosus | EgrG_000407400 | actin |
| Entamoeba histolytica | EHI_159150 | actin, putative |
| Entamoeba histolytica | EHI_163750 | actin, putative |
| Entamoeba histolytica | EHI_107290 | actin, putative |
| Entamoeba histolytica | EHI_142730 | actin, putative |
| Entamoeba histolytica | EHI_043640 | actin, putative |
| Entamoeba histolytica | EHI_126190 | actin, putative |
| Entamoeba histolytica | EHI_182900 | actin |
| Entamoeba histolytica | EHI_140120 | actin, putative |
| Echinococcus multilocularis | EmuJ_000006900 | actin |
| Echinococcus multilocularis | EmuJ_000407400 | actin |
| Echinococcus multilocularis | EmuJ_000703300 | actin |
| Echinococcus multilocularis | EmuJ_000916000 | actin |
| Echinococcus multilocularis | EmuJ_000061200 | actin |
| Echinococcus multilocularis | EmuJ_000407300 | actin |
| Echinococcus multilocularis | EmuJ_000406900 | Actin, cytoplasmic A3 |
| Echinococcus multilocularis | EmuJ_000190400 | cytoplasmic actin |
| Echinococcus multilocularis | EmuJ_000701700 | actin |
| Echinococcus multilocularis | EmuJ_000928900 | expressed conserved protein |
| Echinococcus multilocularis | EmuJ_000407200 | Actin, cytoplasmic A3 |
| Echinococcus multilocularis | EmuJ_000044200 | actin |
| Echinococcus multilocularis | EmuJ_000036300 | actin, cytoplasmic type 5 |
| Giardia lamblia | GL50803_40817 | ACTIN |
| Homo sapiens | ENSG00000183206 | POTE ankyrin domain family, member C |
| Homo sapiens | ENSG00000233917 | POTE ankyrin domain family, member B |
| Homo sapiens | 339010 | POTE ankyrin domain family member B isoform X1 |
| Homo sapiens | ENSG00000184009 | actin, gamma 1 |
| Homo sapiens | ENSG00000187537 | POTE ankyrin domain family, member M |
| Homo sapiens | ENSG00000075624 | actin, beta |
| Homo sapiens | ENSG00000277630 | POTE ankyrin domain family member D-like |
| Homo sapiens | ENSG00000143632 | actin, alpha 1, skeletal muscle |
| Homo sapiens | ENSG00000166351 | POTE ankyrin domain family, member D |
| Homo sapiens | ENSG00000163017 | actin, gamma 2, smooth muscle, enteric |
| Homo sapiens | ENSG00000159251 | actin, alpha, cardiac muscle 1 |
| Homo sapiens | ENSG00000107796 | actin, alpha 2, smooth muscle, aorta |
| Homo sapiens | 340441 | POTE ankyrin domain family, member A |
| Homo sapiens | ENSG00000187537 | POTE ankyrin domain family, member G |
| Homo sapiens | 653269 | POTE ankyrin domain family, member I |
| Homo sapiens | ENSG00000222038 | POTE ankyrin domain family, member J |
| Homo sapiens | ENSG00000188219 | POTE ankyrin domain family, member E |
| Homo sapiens | 102723502 | POTE ankyrin domain family member B-like |
| Homo sapiens | ENSG00000198062 | POTE ankyrin domain family, member H |
| Homo sapiens | ENSG00000230031 | POTE ankyrin domain family, member B2 |
| Homo sapiens | ENSG00000169067 | actin, beta-like 2 |
| Homo sapiens | 102724631 | POTE ankyrin domain family, member B3 |
| Homo sapiens | ENSG00000196604 | POTE ankyrin domain family, member F |
| Leishmania braziliensis | LbrM.04.1250 | actin |
| Leishmania donovani | LdBPK_041250.1 | actin |
| Leishmania infantum | LinJ.04.1250 | actin |
| Leishmania major | LmjF.04.1230 | actin |
| Leishmania mexicana | LmxM.04.1230 | actin |
| Loa Loa (eye worm) | LOAG_15273 | beta-actin |
| Loa Loa (eye worm) | LOAG_09787 | actin 2 |
| Loa Loa (eye worm) | LOAG_11282 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_04142 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_12610 | hypothetical protein |
| Mus musculus | ENSMUSG00000029580 | actin, beta |
| Mus musculus | ENSMUSG00000059430 | actin, gamma 2, smooth muscle, enteric |
| Mus musculus | 11475 | actin, alpha 2, smooth muscle, aorta |
| Mus musculus | ENSMUSG00000062825 | actin, gamma, cytoplasmic 1 |
| Mus musculus | ENSMUSG00000055194 | actin, beta-like 2 |
| Mus musculus | ENSMUSG00000068614 | actin, alpha, cardiac muscle 1 |
| Mus musculus | ENSMUSG00000031972 | actin, alpha 1, skeletal muscle |
| Neospora caninum | NCLIV_003440 | Actin, related |
| Oryza sativa | 4333919 | Os03g0718100 |
| Oryza sativa | 4352927 | Os12g0641000 |
| Oryza sativa | 4351585 | Os12g0163700 |
| Oryza sativa | 4349863 | Os11g0163100 |
| Oryza sativa | 4338914 | Os05g0438800 |
| Oryza sativa | 4349087 | Os10g0510000 |
| Oryza sativa | 4334702 | Os03g0836000 |
| Oryza sativa | 4337566 | Os05g0106600 |
| Onchocerca volvulus | OVOC8134 | Actin, aortic smooth muscle homolog |
| Onchocerca volvulus | OVOC2744 | Actin, aortic smooth muscle homolog |
| Onchocerca volvulus | OVOC2745 | Actin, aortic smooth muscle homolog |
| Plasmodium berghei | PBANKA_1459300 | actin I |
| Plasmodium berghei | PBANKA_1030100 | actin II |
| Plasmodium falciparum | PF3D7_1246200 | actin I |
| Plasmodium falciparum | PF3D7_1412500 | actin II |
| Plasmodium knowlesi | PKNH_1345800 | actin II, putative |
| Plasmodium knowlesi | PKNH_1465800 | actin I, putative |
| Plasmodium vivax | PVX_085830 | actin II |
| Plasmodium vivax | PVX_101200 | actin |
| Plasmodium yoelii | PY02240 | actin |
| Plasmodium yoelii | PY01545 | actin ii |
| Saccharomyces cerevisiae | YFL039C | actin |
| Schistosoma japonicum | Sjp_0002370 | Actin-2, putative |
| Schistosoma japonicum | Sjp_0035880 | Putative actin-23, putative |
| Schistosoma japonicum | Sjp_0103830 | Actin-2, putative |
| Schistosoma japonicum | Sjp_0122650 | Actin, nonmuscle, putative |
| Schistosoma japonicum | Sjp_0042620 | ko:K05692 actin beta/gamma 1, putative |
| Schistosoma mansoni | Smp_046590 | actin |
| Schistosoma mansoni | Smp_046600 | actin |
| Schistosoma mansoni | Smp_161920 | actin |
| Schmidtea mediterranea | mk4.002945.01 | |
| Schmidtea mediterranea | mk4.015517.00 | |
| Schmidtea mediterranea | mk4.005988.00 | |
| Schmidtea mediterranea | mk4.006627.00 | |
| Schmidtea mediterranea | mk4.005041.02 | |
| Schmidtea mediterranea | mk4.004033.00 | |
| Schmidtea mediterranea | mk4.001359.01 | |
| Schmidtea mediterranea | mk4.026087.00 | |
| Schmidtea mediterranea | mk4.000354.14 | |
| Schmidtea mediterranea | mk4.002767.00 | |
| Schmidtea mediterranea | mk4.003603.00 | Putative actin |
| Schmidtea mediterranea | mk4.013318.00 | |
| Schmidtea mediterranea | mk4.004193.01 | |
| Schmidtea mediterranea | mk4.033173.00 | |
| Schmidtea mediterranea | mk4.009885.00 | |
| Schmidtea mediterranea | mk4.023440.01 | |
| Schmidtea mediterranea | mk4.000995.15 | |
| Schmidtea mediterranea | mk4.005500.01 | |
| Schmidtea mediterranea | mk4.017912.01 | |
| Schmidtea mediterranea | mk4.001433.07 | Putative actin |
| Schmidtea mediterranea | mk4.014093.00 | |
| Schmidtea mediterranea | mk4.016854.00 | |
| Schmidtea mediterranea | mk4.000639.06 | |
| Schmidtea mediterranea | mk4.007808.04 | |
| Schmidtea mediterranea | mk4.001443.01 | |
| Schmidtea mediterranea | mk4.012726.01 | Putative actin |
| Schmidtea mediterranea | mk4.028241.00 | |
| Schmidtea mediterranea | mk4.010857.01 | |
| Schmidtea mediterranea | mk4.010353.01 | |
| Schmidtea mediterranea | mk4.001906.01 | |
| Schmidtea mediterranea | mk4.000723.13 | |
| Schmidtea mediterranea | mk4.003493.00 | |
| Schmidtea mediterranea | mk4.012273.01 | |
| Schmidtea mediterranea | mk4.009292.00 | Putative actin |
| Schmidtea mediterranea | mk4.008786.01 | |
| Schmidtea mediterranea | mk4.003673.03 | |
| Schmidtea mediterranea | mk4.000451.04 | |
| Schmidtea mediterranea | mk4.000953.09 | |
| Schmidtea mediterranea | mk4.004542.01 | |
| Schmidtea mediterranea | mk4.000188.05 | |
| Schmidtea mediterranea | mk4.002275.00 | |
| Schmidtea mediterranea | mk4.015512.01 | Putative actin |
| Schmidtea mediterranea | mk4.014933.01 | |
| Schmidtea mediterranea | mk4.000256.11 | |
| Schmidtea mediterranea | mk4.006158.02 | |
| Schmidtea mediterranea | mk4.003769.03 | |
| Schmidtea mediterranea | mk4.001550.00 | |
| Schmidtea mediterranea | mk4.029183.00 | |
| Schmidtea mediterranea | mk4.001625.01 | |
| Schmidtea mediterranea | mk4.012814.01 | |
| Schmidtea mediterranea | mk4.004349.00 | Putative actin |
| Schmidtea mediterranea | mk4.009191.00 | |
| Schmidtea mediterranea | mk4.003404.08 | |
| Schmidtea mediterranea | mk4.014369.01 | |
| Schmidtea mediterranea | mk4.003423.02 | |
| Schmidtea mediterranea | mk4.064379.01 | |
| Schmidtea mediterranea | mk4.001732.00 | |
| Schmidtea mediterranea | mk4.001269.02 | |
| Schmidtea mediterranea | mk4.025288.01 | |
| Schmidtea mediterranea | mk4.000770.11 | |
| Schmidtea mediterranea | mk4.001145.01 | |
| Schmidtea mediterranea | mk4.005402.02 | |
| Schmidtea mediterranea | mk4.000934.02 | |
| Schmidtea mediterranea | mk4.002449.00 | |
| Schmidtea mediterranea | mk4.015419.00 | |
| Schmidtea mediterranea | mk4.000169.05 | |
| Schmidtea mediterranea | mk4.008706.00 | |
| Schmidtea mediterranea | mk4.024210.00 | Putative actin |
| Schmidtea mediterranea | mk4.018105.01 | |
| Schmidtea mediterranea | mk4.030021.00 | Putative actin |
| Schmidtea mediterranea | mk4.003789.00 | |
| Schmidtea mediterranea | mk4.007689.01 | |
| Schmidtea mediterranea | mk4.002075.02 | |
| Schmidtea mediterranea | mk4.018517.04 | |
| Schmidtea mediterranea | mk4.002386.00 | |
| Schmidtea mediterranea | mk4.007922.00 | |
| Schmidtea mediterranea | mk4.041287.00 | |
| Schmidtea mediterranea | mk4.000985.03 | |
| Schmidtea mediterranea | mk4.000205.03 | |
| Schmidtea mediterranea | mk4.015558.02 | |
| Schmidtea mediterranea | mk4.009424.00 | |
| Schmidtea mediterranea | mk4.002459.01 | Putative actin |
| Schmidtea mediterranea | mk4.010120.00 | |
| Schmidtea mediterranea | mk4.000044.05 | |
| Schmidtea mediterranea | mk4.020144.00 | |
| Schmidtea mediterranea | mk4.004365.00 | |
| Schmidtea mediterranea | mk4.014638.00 | |
| Schmidtea mediterranea | mk4.009693.01 | |
| Schmidtea mediterranea | mk4.005942.01 | Putative actin |
| Schmidtea mediterranea | mk4.014562.00 | |
| Schmidtea mediterranea | mk4.008343.02 | Putative actin |
| Schmidtea mediterranea | mk4.021694.00 | |
| Schmidtea mediterranea | mk4.003273.00 | |
| Schmidtea mediterranea | mk4.006312.01 | |
| Schmidtea mediterranea | mk4.015451.01 | |
| Schmidtea mediterranea | mk4.002026.00 | |
| Schmidtea mediterranea | mk4.002611.00 | |
| Schmidtea mediterranea | mk4.016921.01 | |
| Schmidtea mediterranea | mk4.016864.00 | |
| Schmidtea mediterranea | mk4.027358.01 | |
| Schmidtea mediterranea | mk4.027151.00 | |
| Schmidtea mediterranea | mk4.000665.06 | |
| Schmidtea mediterranea | mk4.000223.12 | Putative actin |
| Schmidtea mediterranea | mk4.002045.02 | |
| Schmidtea mediterranea | mk4.001839.09 | |
| Schmidtea mediterranea | mk4.005571.00 | Putative actin |
| Schmidtea mediterranea | mk4.001072.04 | Putative actin |
| Schmidtea mediterranea | mk4.021336.00 | |
| Schmidtea mediterranea | mk4.000124.08 | |
| Schmidtea mediterranea | mk4.018576.00 | |
| Schmidtea mediterranea | mk4.011075.00 | |
| Schmidtea mediterranea | mk4.020644.01 | |
| Schmidtea mediterranea | mk4.015583.00 | |
| Schmidtea mediterranea | mk4.007816.01 | |
| Schmidtea mediterranea | mk4.006992.02 | |
| Schmidtea mediterranea | mk4.003237.03 | |
| Schmidtea mediterranea | mk4.021106.00 | |
| Schmidtea mediterranea | mk4.033514.00 | |
| Schmidtea mediterranea | mk4.001190.01 | Putative actin |
| Schmidtea mediterranea | mk4.003973.00 | Actin-like protein 53D |
| Schmidtea mediterranea | mk4.014316.03 | |
| Schmidtea mediterranea | mk4.000702.05 | |
| Schmidtea mediterranea | mk4.000685.04 | |
| Schmidtea mediterranea | mk4.008198.01 | |
| Schmidtea mediterranea | mk4.009680.02 | |
| Schmidtea mediterranea | mk4.003603.07 | Putative actin |
| Schmidtea mediterranea | mk4.016140.00 | |
| Schmidtea mediterranea | mk4.001354.06 | Putative actin |
| Schmidtea mediterranea | mk4.011934.00 | |
| Schmidtea mediterranea | mk4.001582.12 | |
| Schmidtea mediterranea | mk4.026803.00 | |
| Schmidtea mediterranea | mk4.007461.00 | |
| Schmidtea mediterranea | mk4.013696.00 | |
| Schmidtea mediterranea | mk4.030520.00 | |
| Schmidtea mediterranea | mk4.000320.05 | Putative actin |
| Schmidtea mediterranea | mk4.000261.16 | |
| Schmidtea mediterranea | mk4.001369.08 | |
| Schmidtea mediterranea | mk4.023858.00 | |
| Schmidtea mediterranea | mk4.000373.02 | |
| Schmidtea mediterranea | mk4.028328.00 | |
| Schmidtea mediterranea | mk4.000288.00 | Putative actin |
| Schmidtea mediterranea | mk4.002824.03 | Putative actin |
| Schmidtea mediterranea | mk4.005249.00 | |
| Schmidtea mediterranea | mk4.003603.06 | Putative actin |
| Schmidtea mediterranea | mk4.032568.00 | |
| Schmidtea mediterranea | mk4.011950.00 | |
| Schmidtea mediterranea | mk4.000001.21 | |
| Schmidtea mediterranea | mk4.026274.00 | |
| Schmidtea mediterranea | mk4.001237.01 | |
| Schmidtea mediterranea | mk4.018044.00 | Putative actin |
| Schmidtea mediterranea | mk4.005937.00 | |
| Schmidtea mediterranea | mk4.011669.00 | |
| Schmidtea mediterranea | mk4.022651.00 | |
| Schmidtea mediterranea | mk4.009711.00 | |
| Schmidtea mediterranea | mk4.003168.01 | |
| Schmidtea mediterranea | mk4.020591.00 | |
| Schmidtea mediterranea | mk4.005790.02 | |
| Schmidtea mediterranea | mk4.002369.00 | |
| Schmidtea mediterranea | mk4.000651.00 | |
| Schmidtea mediterranea | mk4.007268.01 | |
| Schmidtea mediterranea | mk4.004588.01 | |
| Schmidtea mediterranea | mk4.002567.03 | |
| Schmidtea mediterranea | mk4.007536.04 | |
| Schmidtea mediterranea | mk4.004091.01 | |
| Schmidtea mediterranea | mk4.000648.12 | |
| Schmidtea mediterranea | mk4.000470.03 | |
| Schmidtea mediterranea | mk4.031185.00 | |
| Schmidtea mediterranea | mk4.000897.10 | |
| Schmidtea mediterranea | mk4.003320.02 | |
| Schmidtea mediterranea | mk4.021148.00 | |
| Schmidtea mediterranea | mk4.000363.10 | |
| Schmidtea mediterranea | mk4.009306.01 | |
| Schmidtea mediterranea | mk4.011844.02 | |
| Schmidtea mediterranea | mk4.002974.01 | |
| Schmidtea mediterranea | mk4.007773.00 | |
| Schmidtea mediterranea | mk4.000419.13 | |
| Schmidtea mediterranea | mk4.020057.00 | |
| Schmidtea mediterranea | mk4.003290.00 | |
| Schmidtea mediterranea | mk4.024575.01 | |
| Schmidtea mediterranea | mk4.010471.00 | |
| Schmidtea mediterranea | mk4.043082.00 | Putative actin |
| Schmidtea mediterranea | mk4.014488.00 | |
| Schmidtea mediterranea | mk4.033556.00 | |
| Schmidtea mediterranea | mk4.014168.00 | |
| Schmidtea mediterranea | mk4.000336.08 | |
| Schmidtea mediterranea | mk4.016587.00 | |
| Schmidtea mediterranea | mk4.021678.01 | |
| Schmidtea mediterranea | mk4.005207.01 | |
| Schmidtea mediterranea | mk4.013530.00 | |
| Schmidtea mediterranea | mk4.014045.02 | |
| Schmidtea mediterranea | mk4.003104.04 | |
| Schmidtea mediterranea | mk4.000350.01 | |
| Schmidtea mediterranea | mk4.008682.03 | |
| Schmidtea mediterranea | mk4.007761.01 | |
| Schmidtea mediterranea | mk4.002894.03 | |
| Schmidtea mediterranea | mk4.005540.00 | |
| Schmidtea mediterranea | mk4.003062.03 | |
| Schmidtea mediterranea | mk4.003096.04 | |
| Schmidtea mediterranea | mk4.012748.00 | |
| Schmidtea mediterranea | mk4.027124.00 | |
| Schmidtea mediterranea | mk4.008769.02 | |
| Schmidtea mediterranea | mk4.000507.00 | |
| Schmidtea mediterranea | mk4.009235.01 | |
| Schmidtea mediterranea | mk4.012249.00 | |
| Schmidtea mediterranea | mk4.000597.08 | |
| Schmidtea mediterranea | mk4.001537.01 | Putative actin |
| Schmidtea mediterranea | mk4.000148.14 | |
| Schmidtea mediterranea | mk4.000842.01 | |
| Schmidtea mediterranea | mk4.012865.00 | |
| Schmidtea mediterranea | mk4.000616.07 | |
| Schmidtea mediterranea | mk4.028736.00 | |
| Schmidtea mediterranea | mk4.011009.00 | |
| Schmidtea mediterranea | mk4.000720.13 | |
| Schmidtea mediterranea | mk4.048422.00 | |
| Schmidtea mediterranea | mk4.002570.03 | |
| Schmidtea mediterranea | mk4.013911.02 | |
| Schmidtea mediterranea | mk4.010214.04 | |
| Schmidtea mediterranea | mk4.000630.00 | |
| Schmidtea mediterranea | mk4.015520.00 | |
| Schmidtea mediterranea | mk4.012907.00 | Putative actin |
| Schmidtea mediterranea | mk4.002800.03 | |
| Schmidtea mediterranea | mk4.001719.03 | |
| Schmidtea mediterranea | mk4.024756.00 | |
| Schmidtea mediterranea | mk4.000397.01 | |
| Schmidtea mediterranea | mk4.023069.01 | |
| Schmidtea mediterranea | mk4.026620.00 | |
| Schmidtea mediterranea | mk4.015493.00 | |
| Schmidtea mediterranea | mk4.007674.00 | |
| Schmidtea mediterranea | mk4.009267.00 | |
| Schmidtea mediterranea | mk4.019983.01 | |
| Schmidtea mediterranea | mk4.032182.00 | |
| Schmidtea mediterranea | mk4.001029.02 | |
| Schmidtea mediterranea | mk4.001678.04 | |
| Schmidtea mediterranea | mk4.009091.01 | |
| Schmidtea mediterranea | mk4.004254.00 | |
| Schmidtea mediterranea | mk4.001089.01 | |
| Schmidtea mediterranea | mk4.028716.00 | |
| Schmidtea mediterranea | mk4.036726.00 | |
| Schmidtea mediterranea | mk4.005145.03 | |
| Schmidtea mediterranea | mk4.008583.00 | |
| Schmidtea mediterranea | mk4.000584.07 | |
| Schmidtea mediterranea | mk4.015485.00 | |
| Schmidtea mediterranea | mk4.000079.11 | |
| Schmidtea mediterranea | mk4.010683.00 | |
| Schmidtea mediterranea | mk4.001319.00 | |
| Schmidtea mediterranea | mk4.006988.00 | |
| Schmidtea mediterranea | mk4.001808.05 | |
| Schmidtea mediterranea | mk4.000737.03 | |
| Schmidtea mediterranea | mk4.002791.01 | |
| Schmidtea mediterranea | mk4.014405.00 | |
| Schmidtea mediterranea | mk4.002491.00 | |
| Schmidtea mediterranea | mk4.000370.03 | |
| Schmidtea mediterranea | mk4.007453.02 | |
| Schmidtea mediterranea | mk4.002446.00 | |
| Schmidtea mediterranea | mk4.000014.22 | |
| Schmidtea mediterranea | mk4.006043.00 | |
| Schmidtea mediterranea | mk4.008297.01 | |
| Schmidtea mediterranea | mk4.011758.00 | |
| Schmidtea mediterranea | mk4.001289.04 | |
| Schmidtea mediterranea | mk4.022148.00 | |
| Schmidtea mediterranea | mk4.018436.01 | |
| Schmidtea mediterranea | mk4.003274.02 | |
| Schmidtea mediterranea | mk4.006739.00 | |
| Schmidtea mediterranea | mk4.004966.01 | |
| Schmidtea mediterranea | mk4.003098.04 | |
| Schmidtea mediterranea | mk4.001719.04 | |
| Schmidtea mediterranea | mk4.003042.00 | |
| Schmidtea mediterranea | mk4.003060.06 | |
| Schmidtea mediterranea | mk4.023980.00 | |
| Schmidtea mediterranea | mk4.006593.00 | |
| Schmidtea mediterranea | mk4.000835.06 | |
| Schmidtea mediterranea | mk4.000261.12 | Putative actin |
| Schmidtea mediterranea | mk4.035902.00 | |
| Schmidtea mediterranea | mk4.008566.01 | |
| Schmidtea mediterranea | mk4.014569.00 | |
| Schmidtea mediterranea | mk4.018423.00 | |
| Schmidtea mediterranea | mk4.034275.00 | |
| Schmidtea mediterranea | mk4.000855.00 | |
| Schmidtea mediterranea | mk4.012750.01 | |
| Schmidtea mediterranea | mk4.005529.00 | |
| Schmidtea mediterranea | mk4.029983.00 | |
| Schmidtea mediterranea | mk4.012396.00 | |
| Schmidtea mediterranea | mk4.005041.01 | |
| Schmidtea mediterranea | mk4.001112.06 | |
| Schmidtea mediterranea | mk4.002673.01 | |
| Schmidtea mediterranea | mk4.001119.08 | |
| Schmidtea mediterranea | mk4.000128.06 | |
| Schmidtea mediterranea | mk4.000336.06 | |
| Schmidtea mediterranea | mk4.031330.00 | |
| Schmidtea mediterranea | mk4.002512.00 | |
| Schmidtea mediterranea | mk4.004977.00 | |
| Schmidtea mediterranea | mk4.034630.00 | Putative actin |
| Schmidtea mediterranea | mk4.001948.00 | |
| Schmidtea mediterranea | mk4.000799.00 | |
| Schmidtea mediterranea | mk4.000276.13 | |
| Schmidtea mediterranea | mk4.002846.02 | |
| Schmidtea mediterranea | mk4.004421.02 | |
| Schmidtea mediterranea | mk4.018126.01 | |
| Schmidtea mediterranea | mk4.000010.16 | |
| Schmidtea mediterranea | mk4.027423.00 | |
| Schmidtea mediterranea | mk4.001217.02 | |
| Schmidtea mediterranea | mk4.016082.01 | |
| Schmidtea mediterranea | mk4.008757.00 | |
| Schmidtea mediterranea | mk4.007398.00 | Putative actin |
| Schmidtea mediterranea | mk4.013771.01 | |
| Schmidtea mediterranea | mk4.033461.01 | Putative actin |
| Schmidtea mediterranea | mk4.032301.00 | |
| Schmidtea mediterranea | mk4.008576.05 | |
| Schmidtea mediterranea | mk4.000046.07 | |
| Schmidtea mediterranea | mk4.012747.00 | |
| Schmidtea mediterranea | mk4.031573.00 | |
| Schmidtea mediterranea | mk4.000001.25 | |
| Schmidtea mediterranea | mk4.007071.00 | |
| Schmidtea mediterranea | mk4.009941.00 | |
| Schmidtea mediterranea | mk4.002721.02 | |
| Schmidtea mediterranea | mk4.023040.00 | |
| Schmidtea mediterranea | mk4.019440.01 | |
| Schmidtea mediterranea | mk4.001390.05 | |
| Schmidtea mediterranea | mk4.008736.02 | |
| Schmidtea mediterranea | mk4.011433.03 | |
| Schmidtea mediterranea | mk4.024924.00 | |
| Schmidtea mediterranea | mk4.018439.00 | |
| Schmidtea mediterranea | mk4.002666.07 | |
| Schmidtea mediterranea | mk4.000467.07 | |
| Schmidtea mediterranea | mk4.003251.00 | |
| Schmidtea mediterranea | mk4.026123.03 | |
| Schmidtea mediterranea | mk4.019274.00 | |
| Schmidtea mediterranea | mk4.021359.01 | |
| Schmidtea mediterranea | mk4.003548.00 | |
| Schmidtea mediterranea | mk4.000244.04 | |
| Schmidtea mediterranea | mk4.003930.01 | |
| Schmidtea mediterranea | mk4.034351.00 | |
| Schmidtea mediterranea | mk4.001690.01 | |
| Schmidtea mediterranea | mk4.002460.04 | |
| Schmidtea mediterranea | mk4.001965.02 | |
| Schmidtea mediterranea | mk4.003811.02 | |
| Schmidtea mediterranea | mk4.007400.00 | |
| Schmidtea mediterranea | mk4.001812.01 | |
| Schmidtea mediterranea | mk4.017862.00 | Putative actin |
| Schmidtea mediterranea | mk4.000205.04 | |
| Schmidtea mediterranea | mk4.005401.02 | |
| Schmidtea mediterranea | mk4.010344.00 | |
| Schmidtea mediterranea | mk4.016947.00 | |
| Schmidtea mediterranea | mk4.013559.00 | |
| Schmidtea mediterranea | mk4.015517.01 | Putative actin |
| Schmidtea mediterranea | mk4.012907.02 | Putative actin |
| Schmidtea mediterranea | mk4.003092.06 | |
| Schmidtea mediterranea | mk4.017956.05 | |
| Schmidtea mediterranea | mk4.009361.00 | |
| Schmidtea mediterranea | mk4.019607.01 | |
| Schmidtea mediterranea | mk4.007018.00 | |
| Schmidtea mediterranea | mk4.006239.02 | |
| Schmidtea mediterranea | mk4.011085.00 | Putative actin |
| Schmidtea mediterranea | mk4.002847.00 | |
| Schmidtea mediterranea | mk4.005619.02 | |
| Schmidtea mediterranea | mk4.003144.01 | |
| Schmidtea mediterranea | mk4.011887.04 | Putative actin |
| Schmidtea mediterranea | mk4.011660.00 | |
| Schmidtea mediterranea | mk4.018966.00 | |
| Schmidtea mediterranea | mk4.003492.03 | |
| Schmidtea mediterranea | mk4.019824.01 | Putative actin |
| Schmidtea mediterranea | mk4.000839.02 | |
| Schmidtea mediterranea | mk4.000766.00 | |
| Schmidtea mediterranea | mk4.025288.00 | |
| Schmidtea mediterranea | mk4.000914.08 | |
| Schmidtea mediterranea | mk4.013924.00 | Putative actin |
| Schmidtea mediterranea | mk4.007493.01 | |
| Schmidtea mediterranea | mk4.007795.00 | |
| Schmidtea mediterranea | mk4.006034.02 | |
| Schmidtea mediterranea | mk4.012228.00 | Putative actin |
| Schmidtea mediterranea | mk4.023271.00 | Putative actin |
| Schmidtea mediterranea | mk4.011315.00 | |
| Schmidtea mediterranea | mk4.003447.06 | |
| Schmidtea mediterranea | mk4.001359.09 | |
| Schmidtea mediterranea | mk4.010929.01 | |
| Schmidtea mediterranea | mk4.010699.01 | |
| Schmidtea mediterranea | mk4.002836.02 | |
| Schmidtea mediterranea | mk4.026251.00 | |
| Schmidtea mediterranea | mk4.009343.04 | |
| Schmidtea mediterranea | mk4.003234.01 | Putative actin |
| Schmidtea mediterranea | mk4.023586.01 | |
| Schmidtea mediterranea | mk4.010940.01 | |
| Schmidtea mediterranea | mk4.003039.00 | |
| Schmidtea mediterranea | mk4.000089.09 | |
| Schmidtea mediterranea | mk4.022873.01 | |
| Schmidtea mediterranea | mk4.003289.00 | |
| Schmidtea mediterranea | mk4.001012.14 | |
| Schmidtea mediterranea | mk4.010908.00 | |
| Schmidtea mediterranea | mk4.019391.00 | |
| Schmidtea mediterranea | mk4.012273.00 | |
| Schmidtea mediterranea | mk4.002271.07 | Putative actin |
| Schmidtea mediterranea | mk4.018779.00 | |
| Schmidtea mediterranea | mk4.040912.00 | |
| Schmidtea mediterranea | mk4.012814.00 | |
| Schmidtea mediterranea | mk4.000375.04 | |
| Schmidtea mediterranea | mk4.003338.01 | |
| Schmidtea mediterranea | mk4.018105.00 | |
| Schmidtea mediterranea | mk4.001126.03 | Putative actin |
| Schmidtea mediterranea | mk4.004548.08 | |
| Schmidtea mediterranea | mk4.021200.02 | |
| Schmidtea mediterranea | mk4.007808.03 | |
| Schmidtea mediterranea | mk4.013832.00 | |
| Schmidtea mediterranea | mk4.008106.02 | |
| Schmidtea mediterranea | mk4.023808.01 | |
| Schmidtea mediterranea | mk4.001365.03 | |
| Schmidtea mediterranea | mk4.010999.01 | |
| Schmidtea mediterranea | mk4.018524.01 | |
| Schmidtea mediterranea | mk4.028243.01 | Putative actin |
| Schmidtea mediterranea | mk4.006573.00 | |
| Schmidtea mediterranea | mk4.020005.00 | |
| Schmidtea mediterranea | mk4.012563.01 | |
| Schmidtea mediterranea | mk4.025380.00 | |
| Schmidtea mediterranea | mk4.011676.00 | |
| Schmidtea mediterranea | mk4.004322.00 | |
| Schmidtea mediterranea | mk4.016968.00 | Putative actin |
| Schmidtea mediterranea | mk4.000314.14 | |
| Schmidtea mediterranea | mk4.020461.01 | |
| Schmidtea mediterranea | mk4.026505.00 | |
| Schmidtea mediterranea | mk4.005145.01 | |
| Schmidtea mediterranea | mk4.011719.00 | |
| Schmidtea mediterranea | mk4.008334.00 | |
| Schmidtea mediterranea | mk4.002535.06 | |
| Schmidtea mediterranea | mk4.004864.02 | |
| Schmidtea mediterranea | mk4.005554.01 | |
| Schmidtea mediterranea | mk4.000244.03 | |
| Schmidtea mediterranea | mk4.013248.00 | |
| Schmidtea mediterranea | mk4.016783.00 | Putative actin |
| Schmidtea mediterranea | mk4.033622.01 | |
| Schmidtea mediterranea | mk4.006132.01 | |
| Schmidtea mediterranea | mk4.002636.03 | |
| Schmidtea mediterranea | mk4.002897.01 | |
| Schmidtea mediterranea | mk4.018713.00 | |
| Schmidtea mediterranea | mk4.001328.04 | |
| Schmidtea mediterranea | mk4.004369.01 | |
| Schmidtea mediterranea | mk4.005769.00 | Putative actin |
| Schmidtea mediterranea | mk4.021485.00 | |
| Schmidtea mediterranea | mk4.008899.00 | |
| Schmidtea mediterranea | mk4.004023.03 | |
| Schmidtea mediterranea | mk4.030860.00 | |
| Schmidtea mediterranea | mk4.014376.00 | |
| Schmidtea mediterranea | mk4.014679.00 | |
| Schmidtea mediterranea | mk4.007684.02 | |
| Schmidtea mediterranea | mk4.024971.00 | |
| Schmidtea mediterranea | mk4.000139.01 | |
| Schmidtea mediterranea | mk4.015042.01 | |
| Schmidtea mediterranea | mk4.007729.03 | |
| Schmidtea mediterranea | mk4.000223.05 | |
| Trypanosoma brucei gambiense | Tbg972.9.4910 | actin A |
| Trypanosoma brucei gambiense | Tbg972.9.4900 | actin A |
| Trypanosoma brucei | Tb927.9.8850 | actin A |
| Trypanosoma brucei | Tb927.9.8880 | actin B |
| Trypanosoma congolense | TcIL3000_0_09560 | actin A |
| Trypanosoma congolense | TcIL3000_0_09570 | actin A |
| Trypanosoma cruzi | TcCLB.507969.50 | actin 2, putative |
| Trypanosoma cruzi | TcCLB.510571.30 | actin 1, putative |
| Trypanosoma cruzi | TcCLB.507129.10 | actin 2, putative |
| Toxoplasma gondii | TGME49_209030 | actin ACT1 |
| Theileria parva | TP02_0903 | actin, putative |
| Trichomonas vaginalis | TVAG_150270 | actin, putative |
| Trichomonas vaginalis | TVAG_172680 | actin, putative |
| Trichomonas vaginalis | TVAG_512800 | actin, putative |
| Trichomonas vaginalis | TVAG_149090 | actin, putative |
| Trichomonas vaginalis | TVAG_485210 | actin, putative |
| Trichomonas vaginalis | TVAG_054030 | actin, putative |
| Trichomonas vaginalis | TVAG_160060 | actin, putative |
| Trichomonas vaginalis | TVAG_200190 | actin, putative |
| Trichomonas vaginalis | TVAG_090470 | actin, putative |
| Trichomonas vaginalis | TVAG_249200 | actin, putative |
| Trichomonas vaginalis | TVAG_337240 | actin, putative |
| Trichomonas vaginalis | TVAG_310030 | actin, putative |
Essentiality
TcCLB.510571.30 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb09.211.0620 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb09.211.0620 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb09.211.0620 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb09.211.0620 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_T04C12.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T04C12.6 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T04C12.6 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T04C12.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T04C12.6 | Caenorhabditis elegans | sterile | wormbase |
| CELE_T04C12.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T04C12.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T04C12.5 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T04C12.5 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T04C12.5 | Caenorhabditis elegans | sterile | wormbase |
| CELE_T04C12.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T04C12.4 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T04C12.4 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T04C12.4 | Caenorhabditis elegans | sterile | wormbase |
| CELE_M03F4.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_M03F4.2 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_M03F4.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_M03F4.2 | Caenorhabditis elegans | sterile | wormbase |
| CELE_T25C8.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T25C8.2 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T25C8.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T25C8.2 | Caenorhabditis elegans | sterile | wormbase |
| YFL039C | Saccharomyces cerevisiae | inviable | yeastgenome |
| PBANKA_1030100 | Plasmodium berghei | Dispensable | plasmo |
| PBANKA_1459300 | Plasmodium berghei | Essential | plasmo |
| TGME49_209030 | Toxoplasma gondii | Probably essential | sidik |
-
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Xenopus laevis | beta-actin | Compounds | References |
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
No user comments are available for this gene.
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