pI: 8.5933 |
Length (AA): 111 |
MW (Da): 12837 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 84 | 1wii (A) | 5 | 85 | 40.00 | 0 | 0.83 | 1.1 | 1.02 |
4 | 84 | 1wii (A) | 5 | 85 | 40.00 | 0 | 0.88 | 1.20003 | 0.1 |
54 | 108 | 4zlf (A) | 395 | 444 | 28.00 | 0.17 | 0.06 | 0.471795 | 2.02 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring, Sporozoite, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, early schizont, late ring, late trophozoite, Oocyst, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | gametocyte, early trophozoite. | PlasmoDB |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_128595)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G46030 | transcription elongation factor 1-like protein |
Babesia bovis | BBOV_I005090 | putative zinc binding domain (DUF701) |
Brugia malayi | Bm1_19025 | Hypothetical UPF0222 protein Y54G11A.11 in chromosome II |
Candida albicans | CaO19.13944 | similar to S. cerevisiae YKL160W |
Candida albicans | CaO19.6623 | similar to S. cerevisiae YKL160W |
Caenorhabditis elegans | CELE_Y54G11A.11 | Protein Y54G11A.11 |
Cryptosporidium hominis | Chro.50168 | hypothetical protein |
Cryptosporidium parvum | cgd5_2110 | protein with conserved N-terminal localized cysteine-rich domain; predicted archaeo-eukaryotic ribosomal protein |
Dictyostelium discoideum | DDB_G0287203 | elongation factor 1 |
Drosophila melanogaster | Dmel_CG6244 | CG6244 gene product from transcript CG6244-RA |
Drosophila melanogaster | Dmel_CG40228 | CG40228 gene product from transcript CG40228-RC |
Echinococcus multilocularis | EmuJ_000678800 | protein of unknown function DUF701, zinc binding |
Echinococcus multilocularis | EmuJ_000679100 | protein of unknown function DUF701, zinc binding |
Echinococcus multilocularis | EmuJ_000680000 | protein of unknown function DUF701, zinc binding |
Homo sapiens | ENSG00000130165 | elongation factor 1 homolog (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_11768 | hypothetical protein |
Mus musculus | 102640717 | predicted gene, 36718 |
Mus musculus | ENSMUSG00000013822 | elongation factor 1 homolog (ELF1, S. cerevisiae) |
Mus musculus | 102640601 | predicted gene, 36627 |
Neospora caninum | NCLIV_006630 | hypothetical protein, conserved |
Oryza sativa | 4343996 | Os07g0631100 |
Oryza sativa | 4328219 | Os02g0134300 |
Onchocerca volvulus | OVOC10149 | Transcription elongation factor 1 homolog |
Plasmodium berghei | PBANKA_0815600 | transcription elongation factor 1, putative |
Plasmodium falciparum | PF3D7_0914600 | transcription elongation factor 1, putative |
Plasmodium knowlesi | PKNH_0712500 | transcription elongation factor 1, putative |
Plasmodium vivax | PVX_099155 | zinc binding protein, putative |
Plasmodium yoelii | PY06377 | hypothetical protein |
Saccharomyces cerevisiae | YKL160W | Elf1p |
Schistosoma japonicum | Sjp_0085060 | Transcription elongation factor 1 homolog, putative |
Schistosoma mansoni | Smp_118750 | hypothetical protein |
Schmidtea mediterranea | mk4.007128.01 | Transcription elongation factor 1 homolog |
Schmidtea mediterranea | mk4.007357.01 | Transcription elongation factor 1 homolog |
Toxoplasma gondii | TGME49_297730 | transcription elongation factor 1, putative |
Theileria parva | TP03_0547 | hypothetical protein |
Trichomonas vaginalis | TVAG_335930 | transcription elongation factor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_297730 | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.