Detailed view for TcCLB.506247.380

Basic information

TDR Targets ID: 48279
Trypanosoma cruzi, Sperm tail/Sperm tail C-terminal domain containing protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.6313 | Length (AA): 657 | MW (Da): 77473 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14772   Sperm tail
PF14775   Sperm tail C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
132 358 1jad (A) 18 242 14.00 0.00002 0.09 0.42 -0.04
91 610 1hci (A) 273 741 13.00 0 1 0.744276 0.62
94 314 4gnk (E) 967 1164 32.00 0.065 0.02 0.260377 0.95
137 293 3f57 (A) 1701 1891 13.00 0 0.99 0.374765 -0.82
137 371 5cwo (A) 4 220 11.00 0 0.34 0.392486 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130359)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG10958   CG10958 gene product from transcript CG10958-RA
Echinococcus granulosus EgrG_000085100   coiled coil domain containing protein 164
Echinococcus granulosus EgrG_001118000   FAR 17a AIG1 protein
Echinococcus multilocularis EmuJ_000085100   coiled coil domain containing protein 164
Echinococcus multilocularis EmuJ_001118000   FAR 17a AIG1 protein
Giardia lamblia GL50803_16237   Hypothetical protein
Homo sapiens ENSG00000157856   dynein regulatory complex subunit 1
Leishmania braziliensis LbrM.35.6950   hypothetical protein, conserved
Leishmania donovani LdBPK_366900.1   Sperm tail/Sperm tail C-terminal domain containing protein, putative
Leishmania infantum LinJ.36.6900   hypothetical protein, conserved
Leishmania major LmjF.36.6590   hypothetical protein, conserved
Leishmania mexicana LmxM.36.6590   hypothetical protein, conserved
Mus musculus ENSMUSG00000073102   dynein regulatory complex subunit 1
Neospora caninum NCLIV_038490   hypothetical protein, conserved
Plasmodium berghei PBANKA_1038600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1403400   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1354700   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_086265   hypothetical protein, conserved
Plasmodium yoelii PY05274   hypothetical protein
Schistosoma japonicum Sjp_0034050   similar to UPF0407 protein CG10958, putative
Schistosoma mansoni Smp_135670   hypothetical protein
Schmidtea mediterranea mk4.019010.00  
Trypanosoma brucei gambiense Tbg972.10.9650   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.7880   Sperm tail/Sperm tail C-terminal domain containing protein, putative
Trypanosoma congolense TcIL3000_10_6750   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503779.10   Sperm tail/Sperm tail C-terminal domain containing protein, putative
Trypanosoma cruzi TcCLB.504025.19   Sperm tail/Sperm tail C-terminal domain containing protein, putative
Trypanosoma cruzi TcCLB.506247.380   Sperm tail/Sperm tail C-terminal domain containing protein, putative
Toxoplasma gondii TGME49_267875   NBP2b protein, putative
Trichomonas vaginalis TVAG_283010   cingulin, putative
Trichomonas vaginalis TVAG_117030   myosin heavy chain, cardiac muscle isoform, putative

Essentiality

TcCLB.506247.380 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7880 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.7880 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.7880 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.7880 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_267875 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506247.380 (Trypanosoma cruzi), Sperm tail/Sperm tail C-terminal domain containing protein, putative
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