Detailed view for TcCLB.507077.50

Basic information

TDR Targets ID: 48286
Trypanosoma cruzi, conserved protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4184 | Length (AA): 113 | MW (Da): 13031 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01984   Double-stranded DNA-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127711)

Species Accession Gene Product
Arabidopsis thaliana AT1G29850   double-stranded DNA-binding protein
Babesia bovis BBOV_III003540   conserved hypothetical protein
Brugia malayi Bm1_54975   Double-stranded DNA-binding domain containing protein
Candida albicans CaO19.8332   similar to human apoptosis-related, predicted DNA binding protein PDCD5 (NP_004699)
Candida albicans CaO19.713   similar to human apoptosis-related, predicted DNA binding protein PDCD5 (NP_004699)
Caenorhabditis elegans CELE_D2005.3   Protein D2005.3
Cryptosporidium hominis Chro.40253   apoptosis-related protein
Cryptosporidium parvum cgd4_2220   possible double-stranded DNA-binding domain, small conserved protein
Dictyostelium discoideum DDB_G0278111   hypothetical protein
Drosophila melanogaster Dmel_CG13072   Programmed Cell Death 5
Echinococcus granulosus EgrG_000425200   programmed cell death protein 5
Entamoeba histolytica EHI_191910   hypothetical protein, conserved
Entamoeba histolytica EHI_198970   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000425200   programmed cell death protein 5
Giardia lamblia GL50803_10679   Hypothetical protein
Homo sapiens ENSG00000105185   programmed cell death 5
Leishmania braziliensis LbrM.28.2090   hypothetical protein, conserved
Leishmania donovani LdBPK_282040.1   Double-stranded DNA-binding domain containing protein, putative
Leishmania infantum LinJ.28.2040   hypothetical protein, conserved
Leishmania major LmjF.28.1920   hypothetical protein, conserved
Leishmania mexicana LmxM.28.1920   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05987   hypothetical protein
Mus musculus ENSMUSG00000030417   programmed cell death 5
Mus musculus 100042424   predicted gene 3837
Neospora caninum NCLIV_002640   hypothetical protein
Oryza sativa 4339503   Os05g0546500
Oryza sativa 9269971   Os05g0547850
Onchocerca volvulus OVOC9314   Programmed cell death protein 5 homolog
Plasmodium berghei PBANKA_0810500   apoptosis-related protein, putative
Plasmodium falciparum PF3D7_0909300   apoptosis-related protein
Plasmodium knowlesi PKNH_0707300   apoptosis-related protein, putative
Plasmodium vivax PVX_098905   apoptosis-related protein, putative
Plasmodium yoelii PY03132   Unknown-related
Saccharomyces cerevisiae YMR074C   hypothetical protein
Schistosoma japonicum Sjp_0033620   ko:K06875 pdcd5; programmed cell death 5, putative
Schistosoma mansoni Smp_058350   programmed cell death protein
Schmidtea mediterranea mk4.000015.22   Programmed cell death protein 5
Trypanosoma brucei gambiense Tbg972.11.10100   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.9040   conserved protein
Trypanosoma cruzi TcCLB.510899.19   conserved protein
Trypanosoma cruzi TcCLB.507077.50   conserved protein
Theileria parva TP03_0053   hypothetical protein
Trichomonas vaginalis TVAG_390790   programmed cell death, putative
Trichomonas vaginalis TVAG_185560   programmed cell death, putative

Essentiality

TcCLB.507077.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.0780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.0780 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0780 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Tcru008721AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Tcru008721; Recombinant protein: full-length; Source: T cruzi; conserved hypothetical protein ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.507077.50 (Trypanosoma cruzi), conserved protein
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