Detailed view for TcCLB.506495.50

Basic information

TDR Targets ID: 48291
Trypanosoma cruzi, hypothetical protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.1175 | Length (AA): 327 | MW (Da): 33499 | Paralog Number: 2

Signal peptide: Y | GPI Anchor: Y | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
49 302 4w8p (A) 1379 1643 10.00 0 0.02 0.835158 -0.69
187 300 2mqa (A) 24 137 14.00 0 0 0.559024 -1.23
213 294 2eeh (A) 1 100 43.00 0.16 0.24 0.541865 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_130081)

Species Accession Gene Product
Arabidopsis thaliana AT5G04290   kow domain-containing transcription factor 1
Brugia malayi Bm1_14360   Chromadorea ALT protein
Brugia malayi Bm1_06000   hypothetical protein
Brugia malayi Bm1_53280   hypothetical protein
Brugia malayi Bm1_53595   hypothetical protein
Brugia malayi Bm1_19080   gene 11-1 protein precursor
Caenorhabditis elegans CELE_T05C12.10   Protein QUA-1
Cryptosporidium hominis Chro.40415   hypothetical protein
Homo sapiens ENSG00000143520   filaggrin family member 2
Homo sapiens ENSG00000197915   hornerin
Homo sapiens ENSG00000143631   filaggrin
Mus musculus 229574   filaggrin family member 2
Mus musculus ENSMUSG00000041991   hornerin
Neospora caninum NCLIV_005200   hypothetical protein
Neospora caninum NCLIV_032740   hypothetical protein, conserved
Neospora caninum NCLIV_046070   hypothetical protein
Neospora caninum NCLIV_006850   Hornerin, related
Oryza sativa 9268124   Os05g0506200
Oryza sativa 4341701   Os06g0652600
Onchocerca volvulus OVOC12701  
Plasmodium knowlesi PKNH_0303400   liver specific protein 2, putative
Plasmodium vivax PVX_087665   hypothetical protein
Plasmodium vivax PVX_000975   liver specific protein 2, putative
Saccharomyces cerevisiae YPL223C   Gre1p
Trypanosoma cruzi TcCLB.506495.50   hypothetical protein
Trypanosoma cruzi TcCLB.508061.10   hypothetical protein
Trypanosoma cruzi TcCLB.506495.40   hypothetical protein
Toxoplasma gondii TGME49_232800   hypothetical protein
Trichomonas vaginalis TVAG_245830   conserved hypothetical protein

Essentiality

TcCLB.506495.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T05C12.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05C12.10 Caenorhabditis elegans larval arrest wormbase
CELE_T05C12.10 Caenorhabditis elegans slow growth wormbase
CELE_T05C12.10 Caenorhabditis elegans sterile wormbase
TGME49_232800 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506495.50 (Trypanosoma cruzi), hypothetical protein
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