Detailed view for TcCLB.511805.15

Basic information

TDR Targets ID: 48406
Trypanosoma cruzi, ribosomal protein S29, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.9554 | Length (AA): 57 | MW (Da): 6638 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00253   Ribosomal protein S14p/S29e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 57 1fjg (N) 5 57 28.00 0 0.31 1.14 0.97

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 5OPT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127205)

Species Accession Gene Product
Arabidopsis thaliana AT4G33865   40S ribosomal protein S29
Arabidopsis thaliana AT3G44010   40S ribosomal protein S29
Arabidopsis thaliana AT3G43980   40S ribosomal protein S29
Babesia bovis BBOV_III003810   ribosomal protein S14p/S29e, putative
Brugia malayi Bm1_56775   40S ribosomal protein S29
Caenorhabditis elegans CELE_B0412.4   Protein RPS-29
Cryptosporidium parvum cgd8_4050   ribosomal protein S29
Dictyostelium discoideum DDB_G0272308   40S ribosomal protein S29
Drosophila melanogaster Dmel_CG8495   Ribosomal protein S29
Entamoeba histolytica EHI_126250   ribosomal protein S29, putative
Entamoeba histolytica EHI_030070   hypothetical protein
Giardia lamblia GL50803_39483   Ribosomal protein S29A
Homo sapiens ENSG00000213741   ribosomal protein S29
Leishmania braziliensis LbrM.28.2401   40S ribosomal protein S29, putative
Leishmania braziliensis LbrM.28.2661   40S ribosomal protein S29, putative
Leishmania donovani LdBPK_282650.1   ribosomal protein S29, putative
Leishmania donovani LdBPK_282360.1   ribosomal protein S29, putative
Leishmania infantum LinJ.28.2650   ribosomal protein S29, putative
Leishmania infantum LinJ.28.2360   ribosomal protein S29, putative
Leishmania major LmjF.28.2460   ribosomal protein S29, putative
Leishmania major LmjF.28.2205   ribosomal protein S29, putative
Leishmania mexicana LmxM.28.2205   ribosomal protein S29, putative
Mus musculus ENSMUSG00000034892   ribosomal protein S29
Neospora caninum NCLIV_017510   40S ribosomal protein S29, putative
Oryza sativa 4352308   Os12g0508300
Oryza sativa 9267266   Os03g0773150
Oryza sativa 4350976   Os11g0634500
Onchocerca volvulus OVOC13463  
Plasmodium berghei PBANKA_0803400   40S ribosomal protein S29, putative
Plasmodium falciparum PF3D7_0705700   40S ribosomal protein S29, putative
Plasmodium knowlesi PKNH_0104200   40S ribosomal protein S29, putative
Plasmodium vivax PVX_087825   40S ribosomal protein S29, putative
Saccharomyces cerevisiae YLR388W   ribosomal 40S subunit protein S29A
Saccharomyces cerevisiae YDL061C   ribosomal 40S subunit protein S29B
Schistosoma japonicum Sjp_0037240   ko:K02980 small subunit ribosomal protein S29e, putative
Schmidtea mediterranea mk4.000143.00   40S ribosomal protein S29
Trypanosoma brucei Tb927.11.11475   ribosomal protein S14p/S29e
Trypanosoma brucei Tb927.11.11725   ribosomal protein S14p/S29e
Trypanosoma cruzi TcCLB.511805.15   ribosomal protein S29, putative
Trypanosoma cruzi TcCLB.506025.14   ribosomal protein S29, putative
Trypanosoma cruzi TcCLB.511015.20   ribosomal protein S29, putative
Trypanosoma cruzi TcCLB.509201.15   ribosomal protein S29, putative
Trypanosoma cruzi TcCLB.511209.54   ribosomal protein S29, putative
Theileria parva TP02_0222   40S ribosomal protein S29, putative
Trichomonas vaginalis TVAG_131520   40S ribosomal protein S29, putative
Trichomonas vaginalis TVAG_393120   40S ribosomal protein S29, putative
Trichomonas vaginalis TVAG_357220   40S ribosomal protein S29, putative
Trichomonas vaginalis TVAG_366620   40S ribosomal protein S29, putative
Trichomonas vaginalis TVAG_107660   40S ribosomal protein S29, putative
Trichomonas vaginalis TVAG_490210   40S ribosomal protein S29, putative

Essentiality

TcCLB.511805.15 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0412.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0412.4 Caenorhabditis elegans larval arrest wormbase
CELE_B0412.4 Caenorhabditis elegans larval lethal wormbase
CELE_B0412.4 Caenorhabditis elegans slow growth wormbase
CELE_B0412.4 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511805.15 (Trypanosoma cruzi), ribosomal protein S29, putative
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