Detailed view for TcCLB.511737.10

Basic information

TDR Targets ID: 48408
Trypanosoma cruzi, small glutamine-rich tetratricopeptide repeat protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.9569 | Length (AA): 414 | MW (Da): 46136 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00515   Tetratricopeptide repeat
PF13181   Tetratricopeptide repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 257 1p5q (A) 157 403 23.00 0.0000000000016 1 0.69 0.48
178 253 1na3 (A) 9 84 36.00 0.000000034 1 0.84 -2.1
138 288 4i2z (A) 7 166 27.00 0.013 1 0.595134 0.33
138 255 2vyi (A) 90 207 50.00 0 1 1.01262 -1.59
200 255 4w9r (A) 322 377 9.00 0 0.09 0.368866 -1.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128476)

Species Accession Gene Product
Arabidopsis thaliana AT4G08320   tetratricopeptide repeat domain-containing protein
Brugia malayi Bm1_56335   TPR Domain containing protein
Candida albicans CaO19.13245   related to human glu-rich tetratricopeptide repeat protein
Candida albicans CaO19.5823   related to human glu-rich tetratricopeptide repeat protein
Caenorhabditis elegans CELE_R05F9.10   Protein SGT-1
Dictyostelium discoideum DDB_G0280345   tetratricopeptide-like helical domain-containing protein
Drosophila melanogaster Dmel_CG5094   small glutamine-rich tetratricopeptide containing protein
Echinococcus granulosus EgrG_000428500   small glutamine rich tetratricopeptide
Entamoeba histolytica EHI_146980   hypothetical protein, conserved domain containing
Entamoeba histolytica EHI_182700   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000428500   small glutamine rich tetratricopeptide
Giardia lamblia GL50803_7287   Small glutamine-rich tetratricopeptide repeat-containing protein
Homo sapiens ENSG00000197860   small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
Homo sapiens ENSG00000104969   small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
Leishmania braziliensis LbrM.30.2700   small glutamine-rich tetratricopeptide repeat protein, putative;with=GeneDB:LinJ30_V3.2470
Leishmania donovani LdBPK_302740.1   TPR domain protein, conserved
Leishmania infantum LinJ.30.2740   small glutamine-rich tetratricopeptide repeat protein
Leishmania major LmjF.30.2740   small glutamine-rich tetratricopeptide repeat protein, putative
Leishmania mexicana LmxM.29.2740   TPR domain protein, conserved
Loa Loa (eye worm) LOAG_03987   TPR Domain containing protein
Mus musculus ENSMUSG00000042743   small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
Mus musculus ENSMUSG00000004937   small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
Oryza sativa 4337495   Os04g0690300
Saccharomyces cerevisiae YOR007C   Sgt2p
Schistosoma japonicum Sjp_0097730   IPR001440,Tetratricopeptide TPR_1;IPR013026,Tetratricopeptide region,domain-containing
Schistosoma japonicum Sjp_0130910   expressed protein
Schistosoma mansoni Smp_065980   heat shock protein 70
Schmidtea mediterranea mk4.030668.00  
Schmidtea mediterranea mk4.013496.02  
Trypanosoma brucei gambiense Tbg972.6.3780   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.4000   small glutamine-rich tetratricopeptide repeat protein, putative
Trypanosoma congolense TcIL3000_6_3410   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511737.10   small glutamine-rich tetratricopeptide repeat protein, putative
Trichomonas vaginalis TVAG_015860   tetratricopeptide repeat protein, tpr, putative

Essentiality

TcCLB.511737.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4000 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.4000 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4000 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.4000 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R05F9.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_R05F9.10 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.511737.10 (Trypanosoma cruzi), small glutamine-rich tetratricopeptide repeat protein, putative
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