Detailed view for PF3D7_0916700

Basic information

TDR Targets ID: 4842
Plasmodium falciparum, RNA-binding protein musashi, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.5102 | Length (AA): 388 | MW (Da): 45143 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
134 302 1fje (B) 7 175 20.00 0 1 0.35 0.24
224 301 1rk8 (A) 73 152 18.00 0.000071 0.92 0.65 -2.11
142 211 4c7q (A) 7 79 36.00 0.00016 1 0.783412 -1.94
142 356 3sde (A) 83 271 30.00 0.0000000025 1 0.758124 0.25
225 269 2dnq (A) 3 40 53.00 0.014 1 0.640979 -0.86
226 281 1x4e (A) 8 64 36.00 0.081 1 0.65633 -0.73
142 356 3sde (A) 83 271 30.00 0.0000000037 1 0.778124 0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, Ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, early trophozoite, late ring, late schizont, Female Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, early schizont, late trophozoite, Oocyst. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_133793)

Species Accession Gene Product
Arabidopsis thaliana AT3G56860   UBP1-associated protein 2A
Arabidopsis thaliana AT2G41060   RNA recognition motif-containing protein
Arabidopsis thaliana AT3G15010   RNA recognition motif-containing protein
Cryptosporidium hominis Chro.70495   UBP1 interacting protein 2a
Cryptosporidium hominis Chro.50160   RNA-binding protein
Cryptosporidium parvum cgd7_4480   T8M16_190 RRM protein of possible plant origin
Cryptosporidium parvum cgd5_2200   T8M16_190-plant like protein with RRM domain
Entamoeba histolytica EHI_121780   enhancer binding protein-1
Oryza sativa 4326641   Os01g0614500
Oryza sativa 9269235   Os10g0362150
Oryza sativa 4326212   Os01g0265800
Oryza sativa 4337147   Os04g0636900
Plasmodium berghei PBANKA_0817700   RNA-binding protein musashi, putative
Plasmodium falciparum PF3D7_0916700   RNA-binding protein musashi, putative
Plasmodium knowlesi PKNH_0714700   RNA-binding protein musashi, putative
Plasmodium vivax PVX_099257   RNA-binding protein musashi, putative
Plasmodium yoelii PY06963   UBP1 interacting protein 2a

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0916700 (Plasmodium falciparum), RNA-binding protein musashi, putative
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