Detailed view for TcCLB.511865.19

Basic information

TDR Targets ID: 48484
Trypanosoma cruzi, frataxin-like, mitochondrial precursor, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.0953 | Length (AA): 186 | MW (Da): 20023 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01491   Frataxin-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004322   ferroxidase activity  
GO:0005739   mitochondrion  
GO:0008199   ferric iron binding  
GO:0055114   oxidation reduction  
GO:0016226   iron-sulfur cluster assembly  

Metabolic Pathways

Porphyrin and chlorophyll metabolism (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
69 186 1ew4 (A) 1 105 26.00 0 0.82 0.9 -1.19
54 182 3oeq (A) 54 172 31.00 0 0.99 0.974848 -0.15
60 186 3t3l (A) 94 200 41.00 0.00000000066 0.75 0.943996 0.16
69 186 4hs5 (A) 1 103 25.00 0 0.95 0.954709 -1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128372)

Species Accession Gene Product
Arabidopsis thaliana AT4G03240   frataxin
Brugia malayi Bm1_11575   Frataxin-like domain containing protein
Candida albicans CaO19.1413   Mitochondrial iron uptake
Candida albicans CaO19.8989   Mitochondrial iron uptake
Caenorhabditis elegans CELE_F59G1.7   Protein FRH-1
Cryptosporidium hominis Chro.50410   hypothetical protein
Cryptosporidium parvum cgd5_4320   frataxin like protein
Dictyostelium discoideum DDB_G0293246   hypothetical protein
Drosophila melanogaster Dmel_CG8971   frataxin homolog
Escherichia coli b3807   iron-dependent inhibitor of iron-sulfur cluster formation
Echinococcus granulosus EgrG_000303300   expressed protein
Echinococcus multilocularis EmuJ_000303300   expressed protein
Homo sapiens ENSG00000165060   frataxin
Leishmania braziliensis LbrM.25.0940   frataxin-like protein
Leishmania donovani LdBPK_251090.1   frataxin-like protein
Leishmania infantum LinJ.25.1090   frataxin-like protein
Leishmania major LmjF.25.1050   frataxin-like protein
Leishmania mexicana LmxM.25.1050   frataxin-like protein
Loa Loa (eye worm) LOAG_11762   fxn protein
Mus musculus ENSMUSG00000059363   frataxin
Oryza sativa 4327058   Os01g0783600
Saccharomyces cerevisiae YDL120W   Yfh1p
Schistosoma japonicum Sjp_0009640   Frataxin homolog, mitochondrial precursor, putative
Schistosoma mansoni Smp_137190   frataxin homolog mitochondrial precursor
Schmidtea mediterranea mk4.038550.00  
Schmidtea mediterranea mk4.000577.00   Frataxin, mitochondrial
Trypanosoma brucei gambiense Tbg972.3.690   frataxin-like, mitochondrial precursor, putative
Trypanosoma brucei Tb927.3.1000   frataxin-like, mitochondrial precursor, putative
Trypanosoma cruzi TcCLB.511865.19   frataxin-like, mitochondrial precursor, putative
Trypanosoma cruzi TcCLB.511871.80   frataxin-like, mitochondrial precursor, putative
Trichomonas vaginalis TVAG_114560   conserved hypothetical protein
Trichomonas vaginalis TVAG_182150   conserved hypothetical protein

Essentiality

TcCLB.511865.19 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.1000 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.1000 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.1000 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.1000 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b3807 Escherichia coli non-essential goodall
CELE_F59G1.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_F59G1.7 Caenorhabditis elegans slow growth wormbase
CELE_F59G1.7 Caenorhabditis elegans sterile wormbase
YDL120W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.511865.19 (Trypanosoma cruzi), frataxin-like, mitochondrial precursor, putative
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