Detailed view for TcCLB.508731.20

Basic information

TDR Targets ID: 48549
Trypanosoma cruzi, Alpha/beta hydrolase family, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.9736 | Length (AA): 453 | MW (Da): 50427 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12697   Alpha/beta hydrolase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
56 443 1u2e (A) 0 283 21.00 0 0.99 0.68 0.54
65 244 1ve6 (A) 342 518 14.00 0.000018 0.71 0.54 -0.36
81 183 3e0x (A) 11 102 23.00 0.59 0.95 0.460973 -0.27
83 441 3bf7 (A) 16 252 35.00 0.0000000019 1 0.624094 0.7
86 173 5cta (A) 6 80 37.00 0.1 0.47 0.21286 0.7
369 442 3bdi (A) 131 204 24.00 0.2 0.17 0.415655 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128173)

Species Accession Gene Product
Brugia malayi Bm1_49325   hydrolase, alpha/beta fold family protein
Candida albicans CaO19.13246   match to pfam alpha/beta hydrolase fold
Candida albicans CaO19.2352   similar to S. cerevisiae YGR031W
Candida albicans CaO19.5824   match to pfam alpha/beta hydrolase fold
Candida albicans CaO19.9888   similar to S. cerevisiae YGR031W
Caenorhabditis elegans CELE_R05D7.4   Protein R05D7.4
Dictyostelium discoideum DDB_G0278415   hypothetical protein
Drosophila melanogaster Dmel_CG2059   CG2059 gene product from transcript CG2059-RB
Drosophila melanogaster Dmel_CG14717   CG14717 gene product from transcript CG14717-RB
Escherichia coli b0686   acyl-CoA esterase
Echinococcus granulosus EgrG_000708700   abhydrolase domain containing protein 11
Echinococcus multilocularis EmuJ_000708700   abhydrolase domain containing protein 11
Homo sapiens ENSG00000106077   abhydrolase domain containing 11
Leishmania braziliensis LbrM.13.0940   hypothetical protein, conserved
Leishmania donovani LdBPK_131040.1   Alpha/beta hydrolase family, putative
Leishmania infantum LinJ.13.1040   hypothetical protein, conserved
Leishmania major LmjF.13.1140   hypothetical protein, conserved
Leishmania mexicana LmxM.13.1140   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00082   hypothetical protein
Mus musculus ENSMUSG00000040532   abhydrolase domain containing 11
Mycobacterium tuberculosis Rv0045c   Possible hydrolase
Mycobacterium ulcerans MUL_0063   hydrolase
Neospora caninum NCLIV_016980   hydrolase, alpha/beta fold family domain- containing protein, putative
Plasmodium berghei PBANKA_0906000   alpha/beta hydrolase, putative
Plasmodium falciparum PF3D7_1143000   alpha/beta hydrolase, putative
Plasmodium knowlesi PKNH_0940900   alpha/beta hydrolase, putative
Plasmodium vivax PVX_092755   alpha/beta hydrolase, putative
Plasmodium yoelii PY04076   putative esterase/lipase hi0193
Saccharomyces cerevisiae YGR031W   Imo32p
Schistosoma japonicum Sjp_0217850   ko:K01175 ABHD11,abhydrolase domain containing 11 [EC:3.1.-.-], putative
Schistosoma mansoni Smp_193750   family S33 non-peptidase homologue (S33 family)
Schmidtea mediterranea mk4.000999.02   Family S33 non-peptidase homologue
Trypanosoma brucei gambiense Tbg972.11.4220   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.3690   Alpha/beta hydrolase family, putative
Trypanosoma congolense TcIL3000.11.3640   Alpha/beta hydrolase family, putative
Trypanosoma cruzi TcCLB.509683.40   Alpha/beta hydrolase family, putative
Trypanosoma cruzi TcCLB.508731.20   Alpha/beta hydrolase family, putative
Toxoplasma gondii TGME49_240830   hydrolase, alpha/beta fold family protein

Essentiality

TcCLB.508731.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.1170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.1170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.1170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.1170 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0686 Escherichia coli non-essential goodall
PBANKA_0906000 Plasmodium berghei Dispensable plasmo
TGME49_240830 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus abhydrolase domain containing 11 Compounds References
Homo sapiens abhydrolase domain containing 11 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0072 0.6136 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.508731.20 (Trypanosoma cruzi), Alpha/beta hydrolase family, putative
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