pI: 9.058 |
Length (AA): 222 |
MW (Da): 25289 |
Paralog Number:
1
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 126 | 2dmw (A) | 8 | 129 | 20.00 | 0 | 1 | 0.899268 | -1.44 |
1 | 167 | 4b93 (A) | 1 | 163 | 26.00 | 0 | 1 | 1.14295 | -1.22 |
2 | 121 | 1ifq (A) | 1 | 126 | 14.00 | 0.0000000071 | 0.89 | 0.777241 | -1.49 |
3 | 183 | 3kyq (A) | 24 | 192 | 22.00 | 0 | 1 | 1.08502 | -0.41 |
126 | 188 | 2nps (A) | 50 | 112 | 37.00 | 0.000014 | 0.04 | 0.712484 | -0.66 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127735)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G32150 | vesicle-associated membrane protein 711 |
Arabidopsis thaliana | AT1G04760 | vesicle-associated membrane protein 726 |
Arabidopsis thaliana | AT2G32670 | vesicle-associated membrane protein 725 |
Arabidopsis thaliana | AT5G22360 | vesicle-associated membrane protein 714 |
Arabidopsis thaliana | AT2G33120 | vesicle-associated membrane protein 722 |
Arabidopsis thaliana | AT2G25340 | vesicle-associated membrane protein 712 |
Arabidopsis thaliana | AT5G11150 | vesicle-associated membrane protein 713 |
Brugia malayi | Bm1_39365 | Synaptobrevin family protein |
Cryptosporidium hominis | Chro.60028 | synaptobrevin-like protein |
Cryptosporidium parvum | cgd6_170 | synaptobrevin-like protein, possible |
Dictyostelium discoideum | DDB_G0277173 | longin domain-containing protein |
Drosophila melanogaster | Dmel_CG1599 | Vesicle-associated membrane protein 7 |
Entamoeba histolytica | EHI_170040 | longin-type vesicle-associated membrane protein, putative |
Homo sapiens | ENSG00000124333 | vesicle-associated membrane protein 7 |
Leishmania braziliensis | LbrM.27.2560 | vesicle-associated membrane protein (vamp), putative |
Leishmania donovani | LdBPK_272300.1 | Vesicle-associated membrane protein 7 |
Leishmania infantum | LinJ.27.2300 | vesicle-associated membrane protein (vamp), putative |
Leishmania major | LmjF.27.2350 | R-SNARE protein, putative |
Leishmania mexicana | LmxM.27.2350 | vesicle-associated membrane protein (vamp), putative |
Loa Loa (eye worm) | LOAG_13749 | synaptobrevin family protein |
Mus musculus | 102639650 | predicted gene, 35911 |
Mus musculus | ENSMUSG00000051412 | vesicle-associated membrane protein 7 |
Neospora caninum | NCLIV_030950 | hypothetical protein |
Oryza sativa | 4331049 | Os02g0803600 |
Oryza sativa | 4342638 | Os07g0194000 |
Oryza sativa | 4348130 | Os10g0154000 |
Oryza sativa | 4340278 | Os06g0174400 |
Oryza sativa | 4334472 | Os03g0803000 |
Plasmodium berghei | PBANKA_1401700 | SNARE protein, putative |
Plasmodium falciparum | PF3D7_1303200 | SNARE protein, putative |
Plasmodium knowlesi | PKNH_1403400 | SNARE protein, putative |
Plasmodium vivax | PVX_122000 | SNARE protein, putative |
Plasmodium yoelii | PY03903 | Arabidopsis thaliana At5g22360/MWD9_16, putative |
Schmidtea mediterranea | mk4.002453.01 | Vesicle-associated membrane protein 7 |
Trypanosoma brucei gambiense | Tbg.972.2.3150 | vesicle-associated membrane protein, putative,synaptobrevin, putative |
Trypanosoma brucei | Tb927.2.5120 | Vesicle-associated membrane protein 7 |
Trypanosoma congolense | TcIL3000_5_3990 | vesicle-associated membrane protein, putative |
Trypanosoma cruzi | TcCLB.507801.179 | Vesicle-associated membrane protein 7 |
Trypanosoma cruzi | TcCLB.511627.60 | Vesicle-associated membrane protein 7 |
Toxoplasma gondii | TGME49_230430 | vesicle-associated membrane protein, putative |
Trichomonas vaginalis | TVAG_476920 | snb-1, putative |
Trichomonas vaginalis | TVAG_037100 | vAMP-4, putative |
Trichomonas vaginalis | TVAG_477050 | vAMP-7, putative |
Trichomonas vaginalis | TVAG_249080 | snare proteins, putative |
Trichomonas vaginalis | TVAG_449870 | snare proteins, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.5120 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.5120 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.5120 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.5120 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1401700 | Plasmodium berghei | Dispensable | plasmo |
TGME49_230430 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.