pI: 7.0623 |
Length (AA): 157 |
MW (Da): 17560 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 152 | 1qgv (A) | 9 | 138 | 44.00 | 0 | 1 | 1.37 | -1.22 |
6 | 150 | 2av4 (A) | 32 | 154 | 46.00 | 0 | 1 | 1.43 | -1.41 |
18 | 123 | 1erv () | 1 | 103 | 15.00 | 0 | 0.61 | 0.85 | -1.92 |
1 | 150 | 2av4 (A) | 27 | 154 | 44.00 | 0 | 1 | 1.39151 | -1.14 |
1 | 153 | 4cdo (A) | 9 | 245 | 46.00 | 0 | 1 | 1.42462 | -0.98 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128171)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G08290 | thioredoxin-like protein YLS8 |
Babesia bovis | BBOV_IV011170 | dim1 protein-like protein, putative |
Brugia malayi | Bm1_33505 | Chain A, Human Spliceosomal Protein U5-15kd. |
Candida albicans | CaO19.1975 | spliceosomal U5 snRNP 15kd protein |
Candida albicans | CaO19.9531 | spliceosomal U5 snRNP 15kd protein |
Caenorhabditis elegans | CELE_Y54G2A.75 | Protein Y54G2A.75 |
Cryptosporidium parvum | cgd8_3690 | mitosis protein DIM1 |
Dictyostelium discoideum | DDB_G0275407 | DIM1-like protein |
Drosophila melanogaster | Dmel_CG3058 | CG3058 gene product from transcript CG3058-RA |
Echinococcus granulosus | EgrG_001045900 | mitosis protein dim1 |
Entamoeba histolytica | EHI_045260 | DIM1 family protein, putative |
Echinococcus multilocularis | EmuJ_001045900 | mitosis protein dim1 |
Giardia lamblia | GL50803_15500 | Hypothetical protein |
Homo sapiens | 10907 | thioredoxin-like 4A |
Leishmania braziliensis | LbrM.23.0750 | spliceosomal U5 snRNP-specific protein, putative,DIM-like protein, putative |
Leishmania donovani | LdBPK_230820.1 | spliceosomal U5 snRNP-specific protein, putative |
Leishmania infantum | LinJ.23.0820 | spliceosomal U5 snRNP-specific protein, putative,DIM-like protein, putative |
Leishmania major | LmjF.23.0650 | spliceosomal U5 snRNP-specific protein, putative,DIM-like protein, putative |
Leishmania mexicana | LmxM.23.0650 | spliceosomal U5 snRNP-specific protein, putative,DIM-like protein, putative |
Loa Loa (eye worm) | LOAG_02998 | thioredoxin-like protein 4A |
Mus musculus | 27366 | thioredoxin-like 4A |
Neospora caninum | NCLIV_036500 | hypothetical protein |
Oryza sativa | 4348949 | Os10g0486600 |
Oryza sativa | 9268087 | Os07g0202450 |
Plasmodium berghei | PBANKA_1446200 | mitosis protein dim1, putative |
Plasmodium falciparum | PF3D7_1231500 | mitosis protein dim1, putative |
Plasmodium knowlesi | PKNH_1450900 | mitosis protein dim1, putative |
Plasmodium vivax | PVX_100520 | mitosis protein dim1, putative |
Plasmodium yoelii | PY07357 | Drosophila melanogaster RE13747p |
Saccharomyces cerevisiae | YPR082C | Dib1p |
Schistosoma japonicum | Sjp_0307100 | Thioredoxin-like protein 4A, putative |
Schistosoma mansoni | Smp_106050 | mitosis protein dim1 |
Schmidtea mediterranea | mk4.003751.00 | Thioredoxin-like protein 4A |
Schmidtea mediterranea | mk4.003306.07 | Thioredoxin-like protein 4A |
Schmidtea mediterranea | mk4.007622.04 | Thioredoxin-like protein 4A |
Trypanosoma brucei gambiense | Tbg972.8.2050 | spliceosomal U5 snRNP-specific protein, putative |
Trypanosoma brucei | Tb927.8.2560 | spliceosomal U5 snRNP-specific protein, putative |
Trypanosoma cruzi | TcCLB.503829.89 | spliceosomal U5 snRNP-specific protein, putative |
Trypanosoma cruzi | TcCLB.508045.79 | spliceosomal U5 snRNP-specific protein, putative |
Toxoplasma gondii | TGME49_270140 | splicing factor DIM1, putative |
Theileria parva | TP01_0642 | mitosis protein dim1, putative |
Trichomonas vaginalis | TVAG_307980 | mitosis protein dim1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.2560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.2560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.2560 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.2560 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y54G2A.75 | Caenorhabditis elegans | embryonic lethal | wormbase |
YPR082C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_270140 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.