Detailed view for PF3D7_0922000

Basic information

TDR Targets ID: 4895
Plasmodium falciparum, dynein intermediate chain, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.4534 | Length (AA): 820 | MW (Da): 97210 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
419 788 1erj (A) 298 708 13.00 0 0.93 0.61 -0.99
464 807 1r5m (A) 155 509 17.00 0.0000000013 1 0.58 -0.44
170 418 4tql (A) 9 238 16.00 0.061 0.2 0.448259 -0.75
428 790 2xyi (A) 16 411 17.00 0 1 0.524383 0.6
604 779 3obr (A) 868 1048 30.00 0.87 0.14 0.0680341 1.71
624 790 3w15 (A) 60 273 25.00 0.00000000014 0.94 0.436359 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile early ring. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 32 hs, gametocyte, Oocyst, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite. Otto TD Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_130052)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG9313   CG9313 gene product from transcript CG9313-RC
Echinococcus granulosus EgrG_000809200   Dynein intermediate chain
Echinococcus multilocularis EmuJ_000809200   Dynein intermediate chain
Giardia lamblia GL50803_33218   Dynein intermediate chain
Homo sapiens ENSG00000122735   dynein, axonemal, intermediate chain 1
Leishmania braziliensis LbrM.24.0280   dynein intermediate-chain-like protein
Leishmania donovani LdBPK_240270.1   Dynein intermediate chain 1, axonemal
Leishmania infantum LinJ.24.0270   dynein intermediate-chain-like protein
Leishmania major LmjF.24.0280   dynein intermediate-chain-like protein
Leishmania mexicana LmxM.24.0280   dynein intermediate-chain-like protein
Mus musculus ENSMUSG00000061322   dynein, axonemal, intermediate chain 1
Neospora caninum NCLIV_003690   dynein intermediate chain, putative
Plasmodium berghei PBANKA_0822900   dynein intermediate chain, putative
Plasmodium falciparum PF3D7_0922000   dynein intermediate chain, putative
Plasmodium knowlesi PKNH_0720000   dynein intermediate chain, putative
Plasmodium vivax PVX_099515   WD domain, G-beta repeat domain containing protein
Plasmodium yoelii PY00184   dynein intermediate chain 2, ciliary
Schistosoma japonicum Sjp_0101560   IPR001680,WD-40 repeat;IPR011046,WD40-like,domain-containing
Schistosoma japonicum Sjp_0030340   ko:K10409 dynein intermediate chain, axonemal, putative
Schistosoma japonicum Sjp_0121490   ko:K10409 dynein intermediate chain, axonemal, putative
Schistosoma japonicum Sjp_0030380   Dynein intermediate chain 2, ciliary, putative
Schistosoma mansoni Smp_167040   axonemal dynein intermediate chain polypeptide
Schistosoma mansoni Smp_082830   axonemal dynein intermediate chain polypeptide
Schmidtea mediterranea mk4.019342.01   Dynein intermediate chain 1, axonemal
Schmidtea mediterranea mk4.006242.01   Putative axonemal dynein intermediate chain polypeptide
Schmidtea mediterranea mk4.000073.11   Dynein intermediate chain 1, axonemal
Schmidtea mediterranea mk4.006242.00  
Schmidtea mediterranea mk4.000073.09   Putative axonemal dynein intermediate chain polypeptide
Schmidtea mediterranea mk4.000073.07  
Trypanosoma brucei gambiense Tbg972.11.5640   dynein intermediate chain, putative
Trypanosoma brucei Tb927.11.5000   Dynein intermediate chain 1, axonemal
Trypanosoma congolense TcIL3000.11.5100   Dynein intermediate chain 1, axonemal
Trypanosoma cruzi TcCLB.507669.70   Dynein intermediate chain 1, axonemal
Trypanosoma cruzi TcCLB.507857.60   Dynein intermediate chain 1, axonemal
Trichomonas vaginalis TVAG_151730   dynein intermediate chain 2, ciliary, putative

Essentiality

PF3D7_0922000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2640 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.2640 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2640 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.2640 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0922000 (Plasmodium falciparum), dynein intermediate chain, putative
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