Detailed view for TcCLB.506715.10

Basic information

TDR Targets ID: 48973
Trypanosoma cruzi, Aurora kinase 3, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.26 | Length (AA): 511 | MW (Da): 56781 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  
GO:0007049   cell cycle  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_137810)

Species Accession Gene Product
Arabidopsis thaliana AT2G45490   serine/threonine-protein kinase aurora-3
Caenorhabditis elegans CELE_K07C11.2   Protein AIR-1
Leishmania braziliensis LbrM.26.2370   protein kinase, putative
Leishmania donovani LdBPK_262460.1   protein kinase, putative
Leishmania infantum LinJ.26.2460   protein kinase, putative
Leishmania major LmjF.26.2440   protein kinase, putative
Leishmania mexicana LmxM.26.2440   protein kinase, putative
Oryza sativa 4334220   Os03g0765000
Trypanosoma brucei gambiense Tbg972.9.370   protein kinase, putative
Trypanosoma brucei Tb11.v5.0874   protein kinase, putative
Trypanosoma brucei Tb927.9.1670   Aurora kinase 3, putative
Trypanosoma congolense TcIL3000_9_260   protein kinase, putative
Trypanosoma cruzi TcCLB.506715.10   Aurora kinase 3, putative
Trypanosoma cruzi TcCLB.510349.80   Aurora kinase 3, putative
Trypanosoma cruzi TcCLB.504655.30   protein kinase, putative

Essentiality

TcCLB.506715.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K07C11.2 Caenorhabditis elegans embryonic arrest wormbase
CELE_K07C11.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K07C11.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 24.8% 315 aa Compounds References
Patiria pectinifera Cdc2 300 aa 26.1% 295 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.6% 293 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 22.2% 180 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.6% 297 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.2% 286 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 30.3% 277 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.6% 313 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0081 0.5 0.5
0.0091 1 0.5
0.0004 0.5 0.5
0.0063 1 0.5
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0059 1 1
0.0069 0.3067 1
0.0066 0.3101 0
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0061 0.6883 0.5304
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0026 0.5 0.5
0.0011 1 0.5
0.0029 0.5 0.5
0.0092 1 0.5
0.0008 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.3649
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0059 1 1
0.0062 0.6935 0
0.0022 0.5 0.5
0.0059 1 1
0.0063 0.7244 0.2543
0.0064 0.3377 0
0.0056 1 0.5
0.0081 1 0.5
0.0088 0.4477 0.5
0.0093 0.8828 0
0.0032 0.5 0.5
0.0037 1 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0033 1 0.5
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0007 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.506715.10 (Trypanosoma cruzi), Aurora kinase 3, putative
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