Detailed view for PF3D7_0925600

Basic information

TDR Targets ID: 4930
Plasmodium falciparum, zinc binding protein (Yippee), putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.3206 | Length (AA): 128 | MW (Da): 14765 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03226   Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 107 5amh (A) 18 120 19.00 0.0091 0.66 0.907225 -0.55
13 107 3cxk (A) 52 136 28.00 0.078 0.96 0.966987 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, merozoite, sporozoite, early schizont, late schizont, late trophozoite, Female Gametocyte, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, early ring, early trophozoite, late ring. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, Oocyst, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_126829)

Species Accession Gene Product
Arabidopsis thaliana AT3G08990   yippee family putative zinc-binding protein
Arabidopsis thaliana AT4G27740   Yippee family putative zinc-binding protein
Arabidopsis thaliana AT3G11230   Yippee family putative zinc-binding protein
Arabidopsis thaliana AT4G27745   Yippee family putative zinc-binding protein
Arabidopsis thaliana AT3G55890   yippee family putative zinc-binding protein
Arabidopsis thaliana AT5G53940   yippee-like zinc-binding protein
Arabidopsis thaliana AT2G40110   Yippee family putative zinc-binding protein
Babesia bovis BBOV_III011030   yippee putative zinc-binding protein
Brugia malayi Bm1_06485   Yippee-like protein 5
Candida albicans CaO19.10876   similar to S. cerevisiae YBL049W
Candida albicans CaO19.3369   similar to D. melanogaster CG15309 gene product
Caenorhabditis elegans CELE_F37A8.5   Protein F37A8.5
Caenorhabditis elegans CELE_B0546.4   Protein B0546.4, isoform B
Dictyostelium discoideum DDB_G0267990   yippee-like protein
Drosophila melanogaster Dmel_CG15309   CG15309 gene product from transcript CG15309-RC
Drosophila melanogaster Dmel_CG1989   CG1989 gene product from transcript CG1989-RA
Echinococcus granulosus EgrG_000146800   yippee protein
Echinococcus granulosus EgrG_000422000   yippee protein
Echinococcus granulosus EgrG_000532500   fad NAD binding oxidoreductases
Echinococcus multilocularis EmuJ_000137400   protein yippee 1
Echinococcus multilocularis EmuJ_000146800   yippee protein
Echinococcus multilocularis EmuJ_000532500   fad NAD binding oxidoreductases
Echinococcus multilocularis EmuJ_000422000   yippee protein
Homo sapiens ENSG00000166793   yippee-like 4 (Drosophila)
Homo sapiens ENSG00000119801   yippee-like 5 (Drosophila)
Homo sapiens ENSG00000090238   yippee-like 3 (Drosophila)
Homo sapiens ENSG00000100027   yippee-like 1 (Drosophila)
Homo sapiens ENSG00000175155   yippee-like 2 (Drosophila)
Leishmania braziliensis LbrM.30.3510   zinc-binding protein (Yippee), putative
Leishmania donovani LdBPK_303520.1   zinc-binding protein (Yippee), putative
Leishmania infantum LinJ.30.3520   zinc-binding protein (Yippee), putative
Leishmania major LmjF.30.3460   zinc-binding protein (Yippee), putative
Leishmania mexicana LmxM.29.3460   zinc-binding protein (Yippee), putative
Loa Loa (eye worm) LOAG_15888   hypothetical protein
Loa Loa (eye worm) LOAG_15216   hypothetical protein
Loa Loa (eye worm) LOAG_06777   hypothetical protein
Mus musculus ENSMUSG00000042675   yippee-like 3 (Drosophila)
Mus musculus ENSMUSG00000018427   yippee-like 2 (Drosophila)
Mus musculus ENSMUSG00000039770   yippee-like 5 (Drosophila)
Mus musculus 241525   yippee-like 4 (Drosophila)
Neospora caninum NCLIV_046350   hypothetical protein
Oryza sativa 9269636   Os10g0369300
Oryza sativa 4333809   Os03g0698500
Oryza sativa 4343737   Os07g0584000
Oryza sativa 9270536   Os03g0193075
Oryza sativa 4352226   Os12g0484700
Oryza sativa 4350710   Os11g0551800
Oryza sativa 9271275   Os10g0369500
Plasmodium berghei PBANKA_0826400   zinc binding protein (Yippee), putative
Plasmodium falciparum PF3D7_0925600   zinc binding protein (Yippee), putative
Plasmodium knowlesi PKNH_0723500   zinc binding protein (Yippee), putative
Plasmodium vivax PVX_099695   zinc binding protein (Yippee), putative
Plasmodium yoelii PY03878   hypothetical protein
Saccharomyces cerevisiae YBL049W   Moh1p
Schistosoma japonicum Sjp_0048700   ko:K08791 LATS, large tumor suppressor, putative
Schistosoma japonicum Sjp_0317520   expressed protein
Schistosoma japonicum Sjp_0078540   Protein yippee, putative
Schistosoma japonicum Sjp_0028780   Protein yippee-like 1, putative
Schistosoma japonicum Sjp_0021300   Protein yippee-like CG15309, putative
Schistosoma mansoni Smp_152180   fad NAD binding oxidoreductases
Schistosoma mansoni Smp_171850   yippee protein
Schmidtea mediterranea mk4.000286.16  
Schmidtea mediterranea mk4.000740.01  
Schmidtea mediterranea mk4.000075.00  
Schmidtea mediterranea mk4.000264.01  
Trypanosoma brucei gambiense Tbg972.6.4640   zinc-binding protein (Yippee), putative
Trypanosoma brucei Tb927.6.4810   zinc-binding protein (Yippee), putative
Trypanosoma congolense TcIL3000_6_4280   zinc-binding protein (Yippee), putative
Trypanosoma cruzi TcCLB.506835.150   zinc-binding protein (Yippee), putative
Trypanosoma cruzi TcCLB.506945.105   zinc-binding protein (Yippee), putative
Toxoplasma gondii TGME49_226640   zinc binding protein, putative
Theileria parva TP02_0036   hypothetical protein, conserved

Essentiality

PF3D7_0925600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4810 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4810 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4810 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.4810 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0546.4 Caenorhabditis elegans slow growth wormbase
PBANKA_0826400 Plasmodium berghei Dispensable plasmo
TGME49_226640 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0925600 (Plasmodium falciparum), zinc binding protein (Yippee), putative
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