Detailed view for TcCLB.506843.70

Basic information

TDR Targets ID: 49339
Trypanosoma cruzi, protein kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.3601 | Length (AA): 339 | MW (Da): 37892 | Paralog Number: 24

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008353   RNA polymerase subunit kinase activity  
GO:0005675   holo TFIIH complex  
GO:0070985   GO:TFIIK complex  

GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 336 2acx (A) 140 450 22.00 0 1 0.97 0.07
46 338 1gz8 (A) 1 290 38.00 0 1 1.34 -1.26
46 337 1unl (A) 1 289 37.00 0 1 1.43 -1.26
3 335 4wih (A) 1 299 22.00 0 1 1.0999 0.26
45 335 3gbz (A) 11 302 37.00 0 1 1.29001 -0.68
45 336 5lqf (A) 0 289 35.00 0 1 1.34196 -0.67
47 336 1ob3 (B) 2 286 42.00 0 1 1.27806 -0.39
157 244 2cmw (A) 148 247 31.00 0.058 0.19 0.299787 1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133587)

Species Accession Gene Product
Leishmania braziliensis LbrM.26.0060   protein kinase, putative
Leishmania donovani LdBPK_260050.1   protein kinase, putative
Leishmania infantum LinJ.26.0050   protein kinase, putative
Leishmania major LmjF.26.0040   protein kinase, putative
Leishmania mexicana LmxM.26.0040   protein kinase, putative
Trypanosoma brucei gambiense Tbg972.7.1890   protein kinase, putative
Trypanosoma brucei Tb927.7.1900   cdc2-related protein kinase 7, putative
Trypanosoma congolense TcIL3000_7_1340   protein kinase, putative
Trypanosoma cruzi TcCLB.509259.130   protein kinase, putative
Trypanosoma cruzi TcCLB.503423.20   protein kinase, putative
Trypanosoma cruzi TcCLB.509163.70   cdc2-related protein kinase 7, putative
Trypanosoma cruzi TcCLB.511055.50   protein kinase, putative
Trypanosoma cruzi TcCLB.507611.40   protein kinase, putative
Trypanosoma cruzi TcCLB.507881.60   protein kinase, putative
Trypanosoma cruzi TcCLB.508325.130   protein kinase, putative
Trypanosoma cruzi TcCLB.506919.90   protein kinase, putative
Trypanosoma cruzi TcCLB.511773.50   protein kinase, putative
Trypanosoma cruzi TcCLB.508479.10   protein kinase, putative
Trypanosoma cruzi TcCLB.504229.30   protein kinase, putative
Trypanosoma cruzi TcCLB.503607.10   protein kinase, putative
Trypanosoma cruzi TcCLB.508325.320   protein kinase, putative
Trypanosoma cruzi TcCLB.510175.160   protein kinase, putative
Trypanosoma cruzi TcCLB.509725.50   protein kinase, putative
Trypanosoma cruzi TcCLB.506537.260   protein kinase, putative
Trypanosoma cruzi TcCLB.511471.60   protein kinase, putative
Trypanosoma cruzi TcCLB.509723.10   protein kinase, putative
Trypanosoma cruzi TcCLB.506843.70   protein kinase, putative
Trypanosoma cruzi TcCLB.505919.40   protein kinase, putative
Trypanosoma cruzi TcCLB.506537.130   protein kinase, putative
Trypanosoma cruzi TcCLB.506349.10   protein kinase, putative
Trypanosoma cruzi TcCLB.511665.130   kinase, putative
Trypanosoma cruzi TcCLB.508207.20   protein kinase, putative
Trypanosoma cruzi TcCLB.510817.10   protein kinase, putative

Essentiality

TcCLB.506843.70 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.1900 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.1900 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.1900 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.1900 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 37.5% 176 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 36.9% 293 aa Compounds References
Patiria pectinifera Cdc2 300 aa 35.2% 301 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 28.2% 316 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 35.6% 292 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 40.1% 292 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0039 0.5 0.5
0.0061 0.6883 0.5304
0.0036 0.5 0.5
0.0026 0.5 0.5
0.0066 0.3101 0
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0027 1 0.5
0.0059 1 1
0.0062 0.6935 0
0.0029 0.5 0.5
0.0011 1 0.5
0.0092 1 0.5
0.0008 0.5 0.5
0.0098 0.3242 0.3649
0.0039 0.9485 0.5
0.0023 0.5 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0081 0.5 0.5
0.0091 1 0.5
0.0004 0.5 0.5
0.0063 1 0.5
0.0033 0.5 0.5
0.0059 1 1
0.0069 0.3067 1
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0037 1 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0033 1 0.5
0.0012 0.5 0.5
0.0064 0.3377 0
0.0022 0.5 0.5
0.0059 1 1
0.0063 0.7244 0.2543
0.0093 0.8828 0
0.0032 0.5 0.5
0.0056 1 0.5
0.0081 1 0.5
0.0088 0.4477 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.506843.70 (Trypanosoma cruzi), protein kinase, putative
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