pI: 6.929 |
Length (AA): 103 |
MW (Da): 12225 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 92 | 1v54 (H) | 7 | 85 | 30.00 | 0 | 0.98 | 0.83 | -0.14 |
11 | 92 | 3ag2 (H) | 7 | 85 | 30.00 | 0 | 0.92 | 1.12822 | -0.58 |
37 | 103 | 2lqt (A) | 14 | 79 | 21.00 | 0 | 0.21 | 0.846585 | -0.32 |
2 | 72 | 3ag2 (H) | 12 | 85 | 28.00 | 0 | 0.84 | 1.27002 | -0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Male Gametocyte. | Lasonder E |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_128087)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G57815 | cytochrome c oxidase subunit 6b-2 |
Arabidopsis thaliana | AT4G28060 | cytochrome c oxidase, subunit 6b |
Arabidopsis thaliana | AT1G22450 | cytochrome C oxidase 6B |
Babesia bovis | BBOV_I001580 | conserved hypothetical protein |
Brugia malayi | Bm1_53760 | cytochrome-c oxidase |
Brugia malayi | Bm1_38460 | cytochrome oxidase c subunit VIb family protein |
Caenorhabditis elegans | CELE_Y71H2AM.5 | Protein Y71H2AM.5 |
Dictyostelium discoideum | DDB_G0284693 | hypothetical protein |
Drosophila melanogaster | Dmel_CG14235 | Cytochrome c oxidase subunit VIb |
Homo sapiens | ENSG00000160471 | cytochrome c oxidase subunit VIb polypeptide 2 (testis) |
Homo sapiens | ENSG00000126267 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) |
Loa Loa (eye worm) | LOAG_11876 | cytochrome oxidase c subunit VIb family protein |
Loa Loa (eye worm) | LOAG_06413 | cytochrome-c oxidase |
Mus musculus | ENSMUSG00000051811 | cytochrome c oxidase subunit VIb polypeptide 2 |
Mus musculus | ENSMUSG00000036751 | cytochrome c oxidase, subunit VIb polypeptide 1 |
Neospora caninum | NCLIV_044600 | hypothetical protein, conserved |
Oryza sativa | 4330974 | Os02g0791400 |
Oryza sativa | 4336292 | Os04g0498200 |
Oryza sativa | 4333018 | Os03g0390400 |
Oryza sativa | 4343941 | Os07g0621600 |
Onchocerca volvulus | OVOC4724 | Cytochrome c oxidase subunit VIb homolog |
Onchocerca volvulus | OVOC7869 | Cytochrome c oxidase subunit VIb homolog |
Plasmodium berghei | PBANKA_0828800 | cytochrome c oxidase subunit 6B, putative |
Plasmodium falciparum | PF3D7_0928000 | cytochrome c oxidase subunit 6B, putative |
Plasmodium knowlesi | PKNH_0726400 | cytochrome c oxidase subunit 6B, putative |
Plasmodium vivax | PVX_099845 | cytochrome c oxidase subunit 6B, putative |
Plasmodium yoelii | PY05587 | hypothetical protein |
Saccharomyces cerevisiae | YLR038C | cytochrome c oxidase subunit VIb |
Schistosoma japonicum | Sjp_0200230 | ko:K00403 cytochrome c oxidase [EC1.9.3.1], putative |
Schistosoma mansoni | Smp_144010.1 | cytochrome C oxidase polypeptide vib |
Schistosoma mansoni | Smp_144000 | cytochrome C oxidase polypeptide vib |
Schistosoma mansoni | Smp_144010.2 | cytochrome C oxidase polypeptide vib |
Schmidtea mediterranea | mk4.002820.00 | Cytochrome c oxidase subunit VIb |
Schmidtea mediterranea | mk4.003337.07 | Cytochrome c oxidase subunit VIb |
Theileria parva | TP01_0588 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y71H2AM.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y71H2AM.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y71H2AM.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y71H2AM.5 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0828800 | Plasmodium berghei | Essential | plasmo |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
39 literature references were collected for this gene.