pI: 4.5551 |
Length (AA): 263 |
MW (Da): 28783 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
76 | 260 | 1ais (A) | 5 | 181 | 25.00 | 0 | 1 | 1 | -0.96 |
79 | 262 | 1ytb (A) | 64 | 239 | 36.00 | 0 | 1 | 1.24 | -1.31 |
22 | 262 | 4b0a (A) | 11 | 339 | 31.00 | 0 | 1 | 1.30015 | -0.37 |
77 | 262 | 3eik (A) | 20 | 197 | 33.00 | 0 | 1 | 1.15482 | -0.67 |
79 | 262 | 1cdw (A) | 158 | 333 | 34.00 | 0 | 1 | 1.12742 | -0.57 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126912)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G55520 | TATA-box-binding protein 2 |
Babesia bovis | BBOV_IV002970 | TATA-box binding protein |
Brugia malayi | Bm1_46430 | TATA-box binding protein |
Candida albicans | CaO19.9395 | potential TATA-binding protein similar to S. cerevisiae TFIID subunit SPT15 (YER148W) |
Candida albicans | CaO19.1837 | potential TATA-binding protein similar to S. cerevisiae TFIID subunit SPT15 (YER148W) |
Caenorhabditis elegans | CELE_T20B12.2 | Protein TBP-1 |
Cryptosporidium hominis | Chro.80238 | TATA-binding protein |
Cryptosporidium parvum | cgd8_2030 | TATA-box factor binding protein |
Dictyostelium discoideum | DDB_G0275617 | TATA-binding protein |
Drosophila melanogaster | Dmel_CG9874 | TATA binding protein |
Drosophila melanogaster | Dmel_CG7562 | TBP-related factor |
Echinococcus granulosus | EgrG_000419500 | TATA box binding protein 2 |
Echinococcus granulosus | EgrG_000972300 | tata box binding protein |
Entamoeba histolytica | EHI_020610 | transcription initiation factor TFIID family protein |
Entamoeba histolytica | EHI_112050 | transcription initiation factor TFIID family protein |
Entamoeba histolytica | EHI_077240 | transcription initiation factor TFIID family protein |
Echinococcus multilocularis | EmuJ_000419500 | TATA box binding protein 2 |
Echinococcus multilocularis | EmuJ_000972300 | tata box binding protein |
Giardia lamblia | GL50803_1721 | TATA-binding protein-like factor |
Homo sapiens | ENSG00000112592 | TATA box binding protein |
Homo sapiens | 387332 | TATA box binding protein like 2 |
Leishmania braziliensis | LbrM.19.1660 | transcription initiation factor-like protein (TFIID-like protein) |
Leishmania donovani | LdBPK_191430.1 | TATA-box-binding protein |
Leishmania infantum | LinJ.19.1430 | transcription initiation factor-like protein (TFIID-like protein) |
Leishmania major | LmjF.19.1390 | transcription initiation factor-like protein (TFIID-like protein) |
Leishmania mexicana | LmxM.19.1390 | transcription initiation factor-like protein (TFIID-like protein) |
Loa Loa (eye worm) | LOAG_01904 | TATA-box binding protein |
Mus musculus | ENSMUSG00000061809 | TATA box binding protein like 2 |
Mus musculus | ENSMUSG00000014767 | TATA box binding protein |
Neospora caninum | NCLIV_027830 | TATA-binding protein, related |
Oryza sativa | 4352633 | Os12g0580300 |
Oryza sativa | 4333619 | Os03g0657000 |
Oryza sativa | 4348699 | Os10g0432300 |
Plasmodium berghei | PBANKA_1105800 | TATA-box binding protein, putative |
Plasmodium falciparum | PF3D7_0506200 | TATA-box-binding protein |
Plasmodium knowlesi | PKNH_1027400 | TATA-box-binding protein, putative |
Plasmodium vivax | PVX_097865 | TATA-box binding protein, putative |
Plasmodium yoelii | PY00712 | transcription initiation factor tfiid |
Saccharomyces cerevisiae | YER148W | TATA-binding protein |
Schistosoma japonicum | Sjp_0304380 | ko:K03120 transcription initiation factor TFIID TATA-box-binding protein, putative |
Schistosoma japonicum | Sjp_0040590 | TATA-box-binding protein, putative |
Schistosoma mansoni | Smp_098950 | TATA-box binding protein |
Schistosoma mansoni | Smp_073680.2 | TATA-box binding protein |
Schmidtea mediterranea | mk4.000997.07 | TATA-box-binding protein |
Schmidtea mediterranea | mk4.000388.09 | TATA-box-binding protein |
Schmidtea mediterranea | mk4.001551.07 | TBP-related factor |
Schmidtea mediterranea | mk4.000454.07 | TATA-box-binding protein |
Schmidtea mediterranea | mk4.000838.01 | TBP-related factor |
Schmidtea mediterranea | mk4.000454.03 | TATA-box-binding protein |
Schmidtea mediterranea | mk4.001551.08 | TBP-related factor |
Schmidtea mediterranea | mk4.002629.02 | TBP-related factor |
Schmidtea mediterranea | mk4.000454.06 | TATA-box-binding protein |
Trypanosoma brucei gambiense | Tbg972.10.19550 | TFIID-like protein, putative |
Trypanosoma brucei | Tb927.10.15950 | TATA-box-binding protein |
Trypanosoma congolense | TcIL3000_10_13790 | TATA-box-binding protein |
Trypanosoma cruzi | TcCLB.511355.7 | TATA-box-binding protein |
Trypanosoma cruzi | TcCLB.503809.149 | TATA-box-binding protein |
Toxoplasma gondii | TGME49_258680 | TATA-box binding protein TBP2 |
Theileria parva | TP01_0630 | transcription initiation factor TFIID, putative |
Trichomonas vaginalis | TVAG_291560 | transcription initiation factor tfiid, putative |
Trichomonas vaginalis | TVAG_285070 | transcription initiation factor tfiid, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.15950 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.15950 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.15950 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.15950 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T20B12.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T20B12.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T20B12.2 | Caenorhabditis elegans | slow growth | wormbase |
YER148W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_258680 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.