Detailed view for PF3D7_0929500

Basic information

TDR Targets ID: 4969
Plasmodium falciparum, conserved protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.8916 | Length (AA): 209 | MW (Da): 24828 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06294   CH-like domain in sperm protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 128 2ee7 (A) 8 127 43.00 0 1 1.25486 -1.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Ring. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Male Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 16 hs, Oocyst, Sporozoite, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_130310)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG16719   CG16719 gene product from transcript CG16719-RA
Drosophila melanogaster Dmel_CG12395   CG12395 gene product from transcript CG12395-RA
Echinococcus granulosus EgrG_000431600   sperm flagellar protein 1
Echinococcus multilocularis EmuJ_000431600   sperm flagellar protein 1
Giardia lamblia GL50803_12046   SPEF1-like protein
Homo sapiens ENSG00000101222   sperm flagellar 1
Leishmania braziliensis LbrM.20.1150   hypothetical protein, conserved
Leishmania donovani LdBPK_341200.1   Domain of Unknown Function (DUF1042), putative
Leishmania infantum LinJ.34.1200   hypothetical protein, conserved
Leishmania major LmjF.34.1120   hypothetical protein, conserved
Leishmania mexicana LmxM.33.1120   hypothetical protein, conserved
Mus musculus ENSMUSG00000027329   sperm flagellar 1
Plasmodium berghei PBANKA_0830300   conserved protein, unknown function
Plasmodium falciparum PF3D7_0929500   conserved protein, unknown function
Plasmodium knowlesi PKNH_0728000   conserved protein, unknown function
Plasmodium vivax PVX_099935   conserved protein, unknown function
Plasmodium yoelii PY05294   Homo sapiens dJ1009E24.4-related
Schistosoma japonicum Sjp_0062730   Sperm flagellar protein 1, putative
Schistosoma mansoni Smp_060160   hypothetical protein
Schmidtea mediterranea mk4.004422.02   Sperm flagellar protein 1
Schmidtea mediterranea mk4.006902.05  
Trypanosoma brucei gambiense Tbg972.4.3140   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.3130   Component of motile flagella 18
Trypanosoma cruzi TcCLB.506435.220   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506265.200   hypothetical protein, conserved
Toxoplasma gondii TGME49_256025   SPEF1 family protein
Trichomonas vaginalis TVAG_010600   conserved hypothetical protein
Trichomonas vaginalis TVAG_396500   Spermatogenesis-associated protein, putative
Trichomonas vaginalis TVAG_182680   conserved hypothetical protein
Trichomonas vaginalis TVAG_173660   conserved hypothetical protein

Essentiality

PF3D7_0929500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.3130 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.3130 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.3130 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.3130 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_256025 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0929500 (Plasmodium falciparum), conserved protein, unknown function
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