Detailed view for PF3D7_0930500

Basic information

TDR Targets ID: 4977
Plasmodium falciparum, diacylglycerol kinase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.117 | Length (AA): 1360 | MW (Da): 160293 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00609   Diacylglycerol kinase accessory domain
PF00781   Diacylglycerol kinase catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0020011   apicoplast  
GO:0004143   diacylglycerol kinase activity  
GO:0016301   kinase activity  
GO:0007205   activation of protein kinase C activity  
GO:0007165   signal transduction  
GO:0007242   intracellular signaling cascade  

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
75 125 1f2i (G) 1108 1158 4.00 0.000013 0 0.1 -0.28
451 793 2fkj (A) 49 349 28.00 0.93 0.02 0.142106 1.8
743 835 3ult (A) 8 107 27.00 0.15 0.02 0.433282 -1.75
829 1231 3v0a (B) 712 1154 28.00 0.00044 0.7 0.163224 1.81
1124 1264 3uau (A) 107 262 32.00 0.6 0.14 0.248576 0.97
1125 1285 2ap3 (A) 14 185 20.00 0.77 0.02 0.274382 -0.28
1150 1355 4tql (A) 24 224 14.00 0.77 0.01 0.241471 -0.13
239 1198 5czz (A) 68 1045 16.00 0.0000002 0.89 0.666566 1.79
733 823 3ult (A) 13 107 29.00 0.084 0.1 0.382707 -1.07
817 1219 3v0a (B) 712 1154 28.00 0.00045 0.7 0.166161 1.81
1098 1282 4u0r (A) 207 469 29.00 0.29 0.55 0.29544 -0.05
1112 1252 3uau (A) 107 262 32.00 0.61 0.14 0.249799 0.97

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, late schizont, Ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, late ring, Oocyst, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 32 hs, gametocyte, early trophozoite, late trophozoite, Female Gametocyte. Otto TD PlasmoDB Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_155356)

Species Accession Gene Product
Cryptosporidium hominis Chro.30302   SgcA
Plasmodium berghei PBANKA_0831200   diacylglycerol kinase, putative
Plasmodium falciparum PF3D7_0930500   diacylglycerol kinase, putative
Plasmodium knowlesi PKNH_0729100   diacylglycerol kinase, putative
Plasmodium vivax PVX_099990   diacylglycerol kinase, putative
Plasmodium yoelii PY01867   Homo sapiens KIAA0718 protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0930500 (Plasmodium falciparum), diacylglycerol kinase, putative
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