Detailed view for PF3D7_0931600

Basic information

TDR Targets ID: 4987
Plasmodium falciparum, conserved protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.9393 | Length (AA): 251 | MW (Da): 30308 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14713   Domain of unknown function (DUF4464)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst. Otto TD Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_130828)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG14017   CG14017 gene product from transcript CG14017-RA
Drosophila melanogaster Dmel_CG3528   CG3528 gene product from transcript CG3528-RA
Drosophila melanogaster Dmel_CG14013   CG14013 gene product from transcript CG14013-RA
Drosophila melanogaster Dmel_CG8138   CG8138 gene product from transcript CG8138-RA
Echinococcus granulosus EgrG_000996100   hypothetical protein
Echinococcus multilocularis EmuJ_000996100   conserved hypothetical protein
Giardia lamblia GL50803_21110   Hypothetical protein
Homo sapiens ENSG00000197826   chromosome 4 open reading frame 22
Leishmania braziliensis LbrM.09.0860   hypothetical protein, conserved
Leishmania donovani LdBPK_090830.1   Domain of unknown function (DUF4464), putative
Leishmania infantum LinJ.09.0830   hypothetical protein, conserved
Leishmania major LmjF.09.0780   hypothetical protein, conserved
Leishmania mexicana LmxM.09.0780   hypothetical protein, conserved
Mus musculus ENSMUSG00000057816   RIKEN cDNA 1700007G11 gene
Plasmodium berghei PBANKA_0832400   conserved protein, unknown function
Plasmodium falciparum PF3D7_0931600   conserved protein, unknown function
Plasmodium knowlesi PKNH_0730300   conserved protein, unknown function
Plasmodium vivax PVX_087125   conserved protein, unknown function
Schistosoma mansoni Smp_121320   hypothetical protein
Schmidtea mediterranea mk4.006888.07  
Trypanosoma brucei gambiense Tbg972.11.14330   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.12860   cAMP response protein, putative
Trypanosoma congolense TcIL3000_0_35780   cAMP response protein, putative
Trypanosoma cruzi TcCLB.503995.40   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511557.20   hypothetical protein, conserved
Trichomonas vaginalis TVAG_318830   conserved hypothetical protein

Essentiality

PF3D7_0931600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.52.0004 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.52.0004 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.52.0004 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.52.0004 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0832400 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0931600 (Plasmodium falciparum), conserved protein, unknown function
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