Detailed view for PF3D7_0932800

Basic information

TDR Targets ID: 4998
Plasmodium falciparum, importin alpha re-exporter, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.9314 | Length (AA): 1342 | MW (Da): 159114 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03378   CAS/CSE protein, C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005634   nucleus  
GO:0008262   importin-alpha export receptor activity  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0003677   DNA binding  
GO:0008283   cell proliferation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
194 528 2fds (A) 3 324 20.00 0.000038 0.22 0.41 -0.88
511 1258 1qbk (B) 10 841 10.00 0 0.97 0.41 -0.88
580 1227 2bpt (A) 239 839 7.00 0 0.69 0.35 -1.14
784 1337 1wa5 (C) 392 942 23.00 0 1 0.89 -2.32
37 805 4wd9 (A) 133 960 13.00 0.0032 0.79 0.491425 1.42
213 1342 1wa5 (C) 1 947 17.00 0 1 0.504427 0.53
784 1337 1wa5 (C) 392 942 23.00 0 1 0.719217 -0.56
6 175 4u5a (C) 47 238 19.00 0.11 0.16 0.20486 -0.07
213 344 4r6f (A) 107 231 29.00 0.88 0.33 0.317681 0.15
265 1339 1z3h (B) 22 947 18.00 0 1 0.498438 0.91
651 1162 4n5a (A) 14 533 16.00 0.83 0.81 0.489275 0.29
777 1334 1wa5 (C) 392 942 23.00 0 1 0.698829 -0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128085)

Species Accession Gene Product
Arabidopsis thaliana AT2G46520   putative cellular apoptosis susceptibility protein / importin-alpha re-exporter
Babesia bovis BBOV_II004290   conserved hypothetical protein
Brugia malayi Bm1_27525   importin beta family protein 5
Candida albicans CaO19.1231   Chromosome segregation
Candida albicans CaO19.1229   corresponds to N-terminus of S. cerevisiae CSE1 and allelic CaP19.8815
Candida albicans CaO19.1230   corresponds to middle of S. cerevisiae CSE1 and C-terminus of allelic CaP19.8815
Candida albicans CaO19.8816   Chromosome segregation
Caenorhabditis elegans CELE_Y48G1A.5   Protein XPO-2
Cryptosporidium hominis Chro.30213   cellular apoptosis susceptibility gene product
Cryptosporidium parvum cgd3_1790   conserved hypothetical protein
Dictyostelium discoideum DDB_G0291838   hypothetical protein
Drosophila melanogaster Dmel_CG13281   CAS/CSE1 segregation protein
Echinococcus granulosus EgrG_001114600   exportin 2
Entamoeba histolytica EHI_111750   importin alpha re-exporter, putative
Echinococcus multilocularis EmuJ_001114600   exportin 2
Homo sapiens ENSG00000124207   CSE1 chromosome segregation 1-like (yeast)
Leishmania braziliensis LbrM.30.3430   CAS/CSE/importin domain protein, putative
Leishmania donovani LdBPK_303440.1   CAS/CSE/importin domain protein, putative
Leishmania infantum LinJ.30.3440   CAS/CSE/importin domain protein, putative
Leishmania major LmjF.30.3390   CAS/CSE/importin domain protein, putative
Leishmania mexicana LmxM.29.3390   CAS/CSE/importin domain protein, putative
Loa Loa (eye worm) LOAG_04783   importin beta family protein 5
Mus musculus ENSMUSG00000002718   chromosome segregation 1-like (S. cerevisiae)
Neospora caninum NCLIV_008100   importin-alpha re-exporter, putative
Oryza sativa 4327779   Os01g0235400
Plasmodium berghei PBANKA_0833600   importin alpha re-exporter, putative
Plasmodium falciparum PF3D7_0932800   importin alpha re-exporter, putative
Plasmodium knowlesi PKNH_0731500   importin alpha re-exporter, putative
Plasmodium vivax PVX_087065   hypothetical protein, conserved
Plasmodium yoelii PY04917   hypothetical protein
Plasmodium yoelii PY04916   ribosomal protein var1, putative
Saccharomyces cerevisiae YGL238W   Cse1p
Schistosoma japonicum Sjp_0219760   IPR005043,CAS/CSE, C-terminal,domain-containing
Schistosoma japonicum Sjp_0076430   Exportin-2, putative
Schistosoma mansoni Smp_128050   importin-alpha re-exporter (chromosome segregation 1-like protein)
Schmidtea mediterranea mk4.006018.01  
Schmidtea mediterranea mk4.018274.00  
Schmidtea mediterranea mk4.006018.00  
Trypanosoma brucei gambiense Tbg972.6.4560   importin-alpha re-exporter protein, putative,cellular apoptosis susceptibility protein, putative
Trypanosoma brucei Tb927.6.4740   importin-alpha re-exporter protein, putative
Trypanosoma congolense TcIL3000_6_4200   importin-alpha re-exporter protein, putative
Trypanosoma cruzi TcCLB.506835.80   CAS/CSE/importin domain protein, putative
Trypanosoma cruzi TcCLB.506945.30   CAS/CSE/importin domain protein, putative
Toxoplasma gondii TGME49_253730   importin-beta N-terminal domain-containing protein
Theileria parva TP04_0541   hypothetical protein, conserved
Trichomonas vaginalis TVAG_179110   importin-alpha re-exporter, putative
Trichomonas vaginalis TVAG_115250   conserved hypothetical protein

Essentiality

PF3D7_0932800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4740 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4740 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4740 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.4740 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y48G1A.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y48G1A.5 Caenorhabditis elegans larval arrest wormbase
CELE_Y48G1A.5 Caenorhabditis elegans slow growth wormbase
CELE_Y48G1A.5 Caenorhabditis elegans sterile wormbase
YGL238W Saccharomyces cerevisiae inviable yeastgenome
TGME49_253730 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0932800 (Plasmodium falciparum), importin alpha re-exporter, putative
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