pI: 6.7645 |
Length (AA): 484 |
MW (Da): 55735 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
29 | 481 | 2a06 (A) | 1 | 443 | 38.00 | 0 | 1 | 1.51 | -1.36 |
40 | 479 | 1hr6 (B) | 24 | 460 | 38.00 | 0 | 1 | 1.44 | -1.38 |
29 | 481 | 2a06 (A) | 1 | 443 | 38.00 | 0 | 1 | 1.43455 | -0.79 |
40 | 478 | 1hr6 (B) | 24 | 459 | 38.00 | 0 | 1 | 1.44362 | -0.87 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Sporozoite, Female Gametocyte, Male Gametocyte. | Zanghi G Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127023)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G02090 | probable mitochondrial-processing peptidase subunit beta |
Babesia bovis | BBOV_IV001260 | mitochondrial processing peptidase beta subunit |
Brugia malayi | Bm1_07510 | mitochondria processing peptidase subunit beta, putative |
Candida albicans | CaO19.3026 | beta-mitochondrial processing peptidase |
Candida albicans | CaO19.10544 | beta-mitochondrial processing peptidase |
Caenorhabditis elegans | CELE_ZC410.2 | Protein MPPB-1 |
Cryptosporidium hominis | Chro.50031 | mitochondrial processing peptidase beta subunit |
Cryptosporidium parvum | cgd5_3400 | mitochondrial processing peptidase beta subunit |
Dictyostelium discoideum | DDB_G0288777 | mitochondrial processing peptidase beta subunit |
Drosophila melanogaster | Dmel_CG3731 | CG3731 gene product from transcript CG3731-RA |
Echinococcus granulosus | EgrG_000113700 | mitochondrial processing peptidase beta subunit |
Entamoeba histolytica | EHI_098460 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000113700 | mitochondrial processing peptidase beta subunit |
Homo sapiens | ENSG00000010256 | ubiquinol-cytochrome c reductase core protein I |
Homo sapiens | 9512 | peptidase (mitochondrial processing) beta |
Leishmania braziliensis | LbrM.34.1300 | mitochondrial processing peptidase, beta subunit, putative,metallo-peptidase, Clan ME, Family M16 |
Leishmania donovani | LdBPK_010670.1 | mitochondrial-processing peptidase subunit beta, putative |
Leishmania donovani | LdBPK_351390.1 | mitochondrial processing peptidase, beta subunit, putative |
Leishmania infantum | LinJ.01.0670 | mitochondrial processing peptide beta subunit, putative,metallo-peptidase, Clan ME, Family M16 |
Leishmania infantum | LinJ.35.1390 | mitochondrial processing peptidase, beta subunit, putative,metallo-peptidase, Clan ME, Family M16 |
Leishmania major | LmjF.35.1380 | mitochondrial processing peptidase, beta subunit, putative,metallo-peptidase, Clan ME, Family M16 |
Leishmania mexicana | LmxM.01.0650 | mitochondrial processing peptide beta subunit, putative,metallo-peptidase, Clan ME, Family M16 |
Leishmania mexicana | LmxM.34.1380 | mitochondrial processing peptidase, beta subunit, putative,metallo-peptidase, Clan ME, Family M16 |
Loa Loa (eye worm) | LOAG_08266 | processing peptidase subunit beta |
Mycobacterium leprae | ML0855 | PROBABLE ZINC PROTEASE PEPR |
Mus musculus | ENSMUSG00000025651 | ubiquinol-cytochrome c reductase core protein 1 |
Mus musculus | ENSMUSG00000029017 | peptidase (mitochondrial processing) beta |
Mycobacterium tuberculosis | Rv2782c | Probable zinc protease PepR |
Neospora caninum | NCLIV_050470 | hypothetical protein |
Oryza sativa | 4332040 | Os03g0212700 |
Plasmodium berghei | PBANKA_0834400 | mitochondrial-processing peptidase subunit beta, putative |
Plasmodium falciparum | PF3D7_0933600 | mitochondrial-processing peptidase subunit beta, putative |
Plasmodium knowlesi | PKNH_0732300 | mitochondrial-processing peptidase subunit beta, putative |
Plasmodium vivax | PVX_087035 | mitochondrial-processing peptidase subunit beta, putative |
Plasmodium yoelii | PY01832 | mitochondrial processing peptidase beta subunit |
Saccharomyces cerevisiae | YLR163C | Mas1p |
Schistosoma japonicum | Sjp_0204880 | ko:K01412 mitochondrial processing peptidase [EC3.4.24.64], putative |
Schistosoma mansoni | Smp_009650.2 | mitochondrial processing peptidase beta-subunit (M16 family) |
Schistosoma mansoni | Smp_009650.1 | mitochondrial processing peptidase beta-subunit (M16 family) |
Schmidtea mediterranea | mk4.000731.00 | Mitochondrial-processing peptidase subunit beta |
Schmidtea mediterranea | mk4.001322.14 | Mitochondrial-processing peptidase subunit beta |
Trypanosoma brucei gambiense | Tbg972.9.2390 | mitochondrial processing peptide beta subunit, putative,metallo-peptidase, Clan ME, Family M16 |
Trypanosoma brucei gambiense | Tbg972.5.1430 | mitochondrial processing peptidase, beta subunit, putative,metallo-peptidase, Clan ME, Family M16, putative |
Trypanosoma brucei | Tb927.9.4520 | Mitochondrial-processing peptidase subunit beta |
Trypanosoma brucei | Tb927.5.1060 | mitochondrial processing peptidase, beta subunit, putative |
Trypanosoma congolense | TcIL3000_5_820 | mitochondrial processing peptidase, beta subunit, putative |
Trypanosoma cruzi | TcCLB.511585.80 | metallo-peptidase, Clan ME, Family M16 |
Trypanosoma cruzi | TcCLB.510155.80 | mitochondrial-processing peptidase subunit beta, putative |
Trypanosoma cruzi | TcCLB.508301.20 | mitochondrial processing peptidase, beta subunit, putative |
Trypanosoma cruzi | TcCLB.511181.50 | mitochondrial processing peptidase, beta subunit, putative |
Theileria parva | TP01_0151 | biquinol-cytochrome C reductase complex core protein I, mitochondrial precursor, putative |
Trichomonas vaginalis | TVAG_233350 | Clan ME, family M16, insulinase-like metallopeptidase |
Wolbachia endosymbiont of Brugia malayi | Wbm0221 | Zn-dependent peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2829 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb09.160.3110 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.3110 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.3110 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.3110 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.5.1060 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.1060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.1060 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.5.1060 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZC410.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
YLR163C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0834400 | Plasmodium berghei | Slow | plasmo |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.