Detailed view for PF3D7_1201400

Basic information

TDR Targets ID: 5062
Plasmodium falciparum, Plasmodium exported protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 3.9942 | Length (AA): 1129 | MW (Da): 132462 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
103 718 4zt9 (C) 476 1364 19.00 0.18 0.98 0.515216 1.4
183 361 4uos (A) 2 176 21.00 0.51 0.5 0.453147 -1.33
196 377 4tql (A) 11 184 27.00 0.23 0.74 0.352705 -0.69
73 787 5czz (A) 252 1020 23.00 0.028 0.88 0.60698 1.42
183 372 4uos (A) 2 185 18.00 0.0013 0.28 0.431561 -1.5
196 377 4tql (A) 11 184 26.00 0.87 0.41 0.291099 -0.53
813 952 4ht4 (A) 26 183 29.00 0.89 0.22 0.356545 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile merozoite, sporozoite, Female Gametocyte, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile gametocyte, late schizont, Oocyst, Ring. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_130499)

Species Accession Gene Product
Plasmodium falciparum PF3D7_1201400   Plasmodium exported protein, unknown function
Trichomonas vaginalis TVAG_004700   neutral sphingomyelinase (N-smase) activation associated factor fan, putative
Trichomonas vaginalis TVAG_349540   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_242490   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_223710   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_107930   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_266330   conserved hypothetical protein
Trichomonas vaginalis TVAG_351710   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_271590   conserved hypothetical protein
Trichomonas vaginalis TVAG_183610   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_071440   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_225370   neurobeachin, putative
Trichomonas vaginalis TVAG_343650   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_404760   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_362310   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_189020   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_116260   neutral sphingomyelinase (N-smase) activation associated factor fan, putative
Trichomonas vaginalis TVAG_051890   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_511260   conserved hypothetical protein
Trichomonas vaginalis TVAG_225450   hypothetical protein
Trichomonas vaginalis TVAG_489220   lysosomal trafficking regulator, putative
Trichomonas vaginalis TVAG_107920   conserved hypothetical protein
Trichomonas vaginalis TVAG_420820   neurobeachin, putative
Trichomonas vaginalis TVAG_125440   conserved hypothetical protein
Trichomonas vaginalis TVAG_477030   neurobeachin, putative
Trichomonas vaginalis TVAG_071330   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_489230   conserved hypothetical protein
Trichomonas vaginalis TVAG_557080   conserved hypothetical protein
Trichomonas vaginalis TVAG_042020   conserved hypothetical protein
Trichomonas vaginalis TVAG_119700   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_087250   lysosomal trafficking regulator, putative
Trichomonas vaginalis TVAG_031070   conserved hypothetical protein
Trichomonas vaginalis TVAG_223750   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_239340   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_424040   neurobeachin, putative
Trichomonas vaginalis TVAG_161110   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_310940   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_065720   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_043560   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_465990   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_475690   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_468650   conserved hypothetical protein
Trichomonas vaginalis TVAG_332090   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_119530   neurobeachin, putative
Trichomonas vaginalis TVAG_299580   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_188790   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_066010   conserved hypothetical protein
Trichomonas vaginalis TVAG_125450   neurobeachin-like protein, putative
Trichomonas vaginalis TVAG_059960   neutral sphingomyelinase (N-smase) activation associated factor fan, putative
Trichomonas vaginalis TVAG_061450   neurobeachin, putative
Trichomonas vaginalis TVAG_374880   neutral sphingomyelinase (N-smase) activation associated factor fan, putative
Trichomonas vaginalis TVAG_148310   conserved hypothetical protein
Trichomonas vaginalis TVAG_374890   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1201400 (Plasmodium falciparum), Plasmodium exported protein, unknown function
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