Detailed view for TcCLB.511855.70

Basic information

TDR Targets ID: 50640
Trypanosoma cruzi, CMGC/MAPK protein kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.4919 | Length (AA): 530 | MW (Da): 60944 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 502 3zs5 (A) 1 351 32.00 0 1 0.760628 1.05
238 468 4nst (A) 832 1032 28.00 0.0000000000064 1 0.672549 -0.26
239 456 5xvu (A) 135 328 32.00 0.0000000000064 1 0.698021 -0.26
261 352 3vut (B) 225 304 53.00 0.0013 0.07 -0.223715 2.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_166691)

Species Accession Gene Product
Leishmania braziliensis LbrM.13.0600   protein kinase, putative
Leishmania donovani LdBPK_130670.1   protein kinase, putative
Leishmania infantum LinJ.13.0670   protein kinase, putative
Leishmania major LmjF.13.0780   protein kinase, putative
Leishmania mexicana LmxM.13.0780   protein kinase, putative
Trypanosoma cruzi TcCLB.506737.20   CMGC/MAPK protein kinase, putative
Trypanosoma cruzi TcCLB.511855.70   CMGC/MAPK protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 25.3% 438 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.3% 460 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0088 0.4477 0.5
0.0081 0.5 0.5
0.0027 1 0.5
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0091 1 0.5
0.0012 0.5 0.5
0.0059 1 1
0.0022 0.5 0.5
0.0093 0.8828 0
0.0012 0.5 0.5
0.0018 0.5 0.5
0.0081 1 0.5
0.0059 1 1
0.0056 1 0.5
0.0026 0.5 0.5
0.0029 0.5 0.5
0.0039 0.5 0.5
0.0037 1 0.5
0.0098 0.3242 0.3649
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0069 0.3067 1
0.0039 0.5 0.5
0.0092 1 0.5
0.0007 0.5 0.5
0.0063 0.7244 0.2543
0.0063 1 0.5
0.0023 0.5 0.5
0.0007 0.5 0.5
0.0066 0.3101 0
0.0008 0.5 0.5
0.0011 1 0.5
0.0033 0.5 0.5
0.0064 0.3377 0
0.0032 0.5 0.5
0.0061 0.6883 0.5304
0.0042 0.5 0.5
0.0039 0.9485 0.5
0.0007 0.5 0.5
0.0062 0.6935 0
0.0033 1 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0036 0.5 0.5
0.0059 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

21 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511855.70 (Trypanosoma cruzi), CMGC/MAPK protein kinase, putative
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