Detailed view for TcCLB.510943.184

Basic information

TDR Targets ID: 50861
Trypanosoma cruzi, tyrosine phosphatase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.7058 | Length (AA): 332 | MW (Da): 37964 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00782   Dual specificity phosphatase, catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0008138   protein tyrosine/serine/threonine phosphatase activity  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 330 1d5r (A) 14 351 32.00 0 1 1.26 -0.62
29 194 1fpz (A) 32 193 17.00 0.00000001 0.94 0.7 -1.33
15 331 3v0d (A) 251 575 25.00 0 1 1.20002 -0.16
17 330 1d5r (A) 14 351 31.00 0 1 1.22698 -0.02
30 205 3v0i (A) 261 434 38.00 0 1 0.76912 -0.35
51 193 3cm3 (A) 1034 1168 21.00 0 0.85 0.626623 -0.36
100 145 3zm1 (A) 423 467 40.00 0.56 0.2 0.133554 1.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128815)

Species Accession Gene Product
Arabidopsis thaliana AT3G50110   protein PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME TEN 3
Arabidopsis thaliana AT3G19420   phosphatase PTEN2
Arabidopsis thaliana AT5G39400   protein PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME TEN 1
Brugia malayi Bm1_36650   daf-18 protein
Candida albicans CaO19_3699   hypothetical protein
Candida albicans CaO19.11183   Putative protein tyrosine phosphatase
Candida albicans CaO19.3699   Putative protein tyrosine phosphatase
Caenorhabditis elegans CELE_T07A9.6   Protein DAF-18
Dictyostelium discoideum DDB_G0287969   C2 tensin-type domain-containing protein
Dictyostelium discoideum DDB_G0285967   C2 tensin-type domain-containing protein
Dictyostelium discoideum DDB_G0286557   3-phosphatidylinositol 3-phosphatase
Drosophila melanogaster Dmel_CG5671   CG5671 gene product from transcript CG5671-RB
Echinococcus granulosus EgrG_000488600   phosphatase and tensin
Entamoeba histolytica EHI_197010   hypothetical protein
Entamoeba histolytica EHI_098450   phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative
Entamoeba histolytica EHI_197000   phosphatidylinositol-3,4,5-trisphosphate3-phosphatase, putative
Echinococcus multilocularis EmuJ_000488600   phosphatase and tensin
Giardia lamblia GL50803_16728   Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Homo sapiens 5728   phosphatase and tensin homolog
Loa Loa (eye worm) LOAG_07756   hypothetical protein
Mus musculus ENSMUSG00000013663   phosphatase and tensin homolog
Oryza sativa 4352052   Os12g0407500
Saccharomyces cerevisiae YNL128W   Tep1p
Schistosoma japonicum Sjp_0217870   ko:K01110 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase [EC3.1.3.67], putative
Schistosoma mansoni Smp_154470   pten
Schmidtea mediterranea mk4.000721.04   Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Schmidtea mediterranea mk4.000578.02   Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Schmidtea mediterranea mk4.001037.00   Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Trypanosoma cruzi TcCLB.510879.160   tyrosine phosphatase, putative
Trypanosoma cruzi TcCLB.504867.114   tyrosine phosphatase, putative
Trypanosoma cruzi TcCLB.510943.184   tyrosine phosphatase, putative
Trichomonas vaginalis TVAG_187740   pten, putative
Trichomonas vaginalis TVAG_044400   pten, putative

Essentiality

TcCLB.510943.184 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T07A9.6 Caenorhabditis elegans larval lethal wormbase
CELE_T07A9.6 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.510943.184 (Trypanosoma cruzi), tyrosine phosphatase, putative
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