Detailed view for TcCLB.511881.10

Basic information

TDR Targets ID: 50883
Trypanosoma cruzi, GCN5-like protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.0163 | Length (AA): 208 | MW (Da): 22664 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06320   GCN5-like protein 1 (GCN5L1)

Gene Ontology

Mouse over links to read term descriptions.
GO:0031083   BLOC-1 complex  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
54 205 2i1k (A) 286 445 16.00 0.088 0.82 0.782769 0.34
104 206 5tgw (A) 4 109 16.00 0.2 0.26 0.604192 -0.89
137 203 2xzr (A) 402 465 33.00 0.64 0.02 0.618615 -0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131232)

Species Accession Gene Product
Arabidopsis thaliana AT2G30330   biogenesis of lysosome-related organelles complex 1 subunit 1
Brugia malayi Bm1_41605   Hypothetical 14.7 kDa protein T20G5.10 in chromosome III
Caenorhabditis elegans CELE_T20G5.10   Protein BLOS-1
Dictyostelium discoideum DDB_G0280077   GCN5-like 1 domain-containing protein
Drosophila melanogaster Dmel_CG30077   Biogenesis of lysosome-related organelles complex 1, subunit 1
Echinococcus granulosus EgrG_000063620   hypothetical protein
Entamoeba histolytica EHI_095830   hypothetical protein
Echinococcus multilocularis EmuJ_000063620   biogenesis of lysosome-related organelles complex 1 subunit 1
Homo sapiens ENSG00000135441   biogenesis of lysosomal organelles complex-1, subunit 1
Loa Loa (eye worm) LOAG_10020   hypothetical protein
Mus musculus ENSMUSG00000090247   biogenesis of lysosomal organelles complex-1, subunit 1
Oryza sativa 4349586   Os11g0112300
Oryza sativa 9267268   Os12g0111900
Schistosoma japonicum Sjp_0068850   Conserved hypothetical protein
Schistosoma mansoni Smp_096250   gcn5-related
Trypanosoma cruzi TcCLB.509453.30   GCN5-like protein, putative
Trypanosoma cruzi TcCLB.511881.10   GCN5-like protein, putative
Trichomonas vaginalis TVAG_084850   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.511881.10 (Trypanosoma cruzi), GCN5-like protein, putative
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