Detailed view for TcCLB.511649.70

Basic information

TDR Targets ID: 51002
Trypanosoma cruzi, structural maintenance of chromosome 3 protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.6435 | Length (AA): 1200 | MW (Da): 137750 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02463   RecF/RecN/SMC N terminal domain
PF06470   SMC proteins Flexible Hinge Domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005694   chromosome  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0051276   chromosome organization and biogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 154 1e69 (A) 1 145 30.00 0.000000000066 1 0.33 -0.19
2 167 1xew (X) 3 167 38.00 0.00000079 1 0.45 0.02
48 598 1qvr (A) 127 765 19.00 0.000045 0.77 0.45 1.33
517 669 1gxj (A) 501 658 24.00 0.0000000068 1 0.44 -0.6
952 1178 1w1w (A) 99 1219 27.00 0.00000000034 1 0.35 0.09
1086 1177 1e69 (A) 1073 1164 43.00 0.000000066 0.65 0.59 -0.52
2 168 3kta (A) 3 168 38.00 0.000000018 1 0.587967 -0.37
2 309 4ux3 (A) 2 1040 39.00 0 1 0.534467 0.94
173 354 5f5p (A) 1434 1609 13.00 0 0.27 0.247467 -1.17
394 813 4rsi (B) 557 948 18.00 0 1 0.3478 0.51
500 676 2wd5 (B) 495 678 32.00 0 1 0.4993 -0.76
1106 1184 4ux3 (A) 1143 1221 49.00 0.00017 0.4 0.440633 1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127789)

Species Accession Gene Product
Arabidopsis thaliana AT2G27170   structural maintenance of chromosome 3
Babesia bovis BBOV_III002920   RecF/RecN/SMC N terminal domain containing protein
Brugia malayi Bm1_41400   SMC proteins Flexible Hinge Domain containing protein
Candida albicans CaO19.7895   potential SMC chromosomal ATPase similar to S. cerevisiae SMC3 (YJL074C) nuclear cohesin complex ATPase
Caenorhabditis elegans CELE_Y47D3A.26   Protein SMC-3, isoform C
Cryptosporidium parvum cgd7_2700   SMC3SMC type chromosomal ABC ATpase
Dictyostelium discoideum DDB_G0276101   structural maintenance of chromosome protein
Drosophila melanogaster Dmel_CG9802   Chromosome-associated protein
Echinococcus granulosus EgrG_001062500   structural maintenance of chromosomes protein 3
Entamoeba histolytica EHI_164820   hypothetical protein
Echinococcus multilocularis EmuJ_001062500   structural maintenance of chromosomes protein 3
Giardia lamblia GL50803_137745   SMC3-like protein
Homo sapiens ENSG00000108055   structural maintenance of chromosomes 3
Leishmania braziliensis LbrM.08.0010   adaptor complex protein (AP) 3 delta subunit 1, putative
Leishmania donovani LdBPK_080010.1   adaptor complex protein (AP) 3 delta subunit 1, putative
Leishmania infantum LinJ.08.0010   adaptor complex protein (AP) 3 delta subunit 1, putative
Leishmania major LmjF.08.0010   adaptor complex protein (AP) 3 delta subunit 1, putative
Leishmania mexicana LmxM.08.0010   adaptor complex protein (AP) 3 delta subunit 1, putative
Loa Loa (eye worm) LOAG_02559   SMC protein Flexible Hinge Domain containing protein
Mus musculus ENSMUSG00000024974   structural maintenance of chromosomes 3
Neospora caninum NCLIV_044540   structural maintenance of chromosome domain- containing protein, putative
Oryza sativa 4328210   Os02g0133300
Oryza sativa 9269307   Os02g0133400
Plasmodium berghei PBANKA_0716000   structural maintenance of chromosomes protein 3, putative
Plasmodium falciparum PF3D7_0414000   structural maintenance of chromosomes protein 3, putative
Plasmodium knowlesi PKNH_0505600   structural maintenance of chromosomes protein 3, putative
Plasmodium vivax PVX_089660   chromosome associated protein, putative
Plasmodium yoelii PY00549   chromosome-associated polypeptide, putative
Saccharomyces cerevisiae YJL074C   cohesin subunit SMC3
Schistosoma japonicum Sjp_0311170   Structural maintenance of chromosomes protein 3, putative
Schistosoma japonicum Sjp_0007580   ko:K06669 structural maintenance of chromosome 3 (chondroitin sulfate, putative
Schistosoma mansoni Smp_134850   Rootletin (Ciliary rootlet coiled-coil protein)
Schistosoma mansoni Smp_145260   structural maintenance of chromosomes smc3
Schmidtea mediterranea mk4.032314.00   Structural maintenance of chromosomes protein 3
Schmidtea mediterranea mk4.002068.00   Structural maintenance of chromosomes protein 3
Trypanosoma brucei gambiense Tbg972.5.4900   structural maintenance of chromosome 3 , putative
Trypanosoma brucei Tb927.5.3510   structural maintenance of chromosome 3 , putative
Trypanosoma congolense TcIL3000_0_18230   structural maintenance of chromosome 3 , putative
Trypanosoma congolense TcIL3000_0_00320   structural maintenance of chromosome 3 , putative
Trypanosoma cruzi TcCLB.503531.49   structural maintenance of chromosome 3, putative
Trypanosoma cruzi TcCLB.511649.70   structural maintenance of chromosome 3 protein, putative
Toxoplasma gondii TGME49_306310   RecF/RecN/SMC N terminal domain-containing protein
Theileria parva TP03_0311   hypothetical protein
Trichomonas vaginalis TVAG_333960   cohesin subunit Smc3
Trichomonas vaginalis TVAG_340870   cohesin subunit Smc3
Trichomonas vaginalis TVAG_193240   cohesin subunit Smc3

Essentiality

TcCLB.511649.70 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.3510 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.5.3510 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.3510 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.3510 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y47D3A.26 Caenorhabditis elegans adult lethal wormbase
CELE_Y47D3A.26 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y47D3A.26 Caenorhabditis elegans slow growth wormbase
CELE_Y47D3A.26 Caenorhabditis elegans sterile wormbase
YJL074C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0716000 Plasmodium berghei Dispensable plasmo
TGME49_306310 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.511649.70 (Trypanosoma cruzi), structural maintenance of chromosome 3 protein, putative
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