Detailed view for TcCLB.505999.30

Basic information

TDR Targets ID: 51118
Trypanosoma cruzi, histone chaperone ASF1A
Source Database / ID:  TriTrypDB  GeneDB

pI: 3.9867 | Length (AA): 163 | MW (Da): 18289 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04729   ASF1 like histone chaperone

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0006333   chromatin assembly or disassembly  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 159 2cu9 (A) 3 161 34.00 0 1 1.39119 -0.75
6 158 5bnx (D) 3 154 36.00 0 1 1.46345 -0.94
6 163 2idc (A) 3 166 38.00 0 1 1.50363 -0.6
6 157 5eii (I) 3 153 39.00 0 1 1.05092 0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127499)

Species Accession Gene Product
Arabidopsis thaliana AT1G66740   putative histone chaperone ASF1A
Arabidopsis thaliana AT5G38110   histone chaperone ASF1B
Babesia bovis BBOV_III011490   anti-silencing protein, ASF1-like family protein
Brugia malayi Bm1_42255   Anti-silencing protein, ASF1-like containing protein
Candida albicans CaO19.3715   Component of replication-coupling assembly factor
Candida albicans CaO19.11200   Component of replication-coupling assembly factor
Caenorhabditis elegans CELE_C03D6.5   Protein ASFL-1
Caenorhabditis elegans CELE_F10G7.3   Protein UNC-85
Cryptosporidium hominis Chro.40095   asf1
Cryptosporidium parvum cgd4_760   possible ASF1 anti-silencing function 1 like protein
Dictyostelium discoideum DDB_G0285513   anti-silencing protein 1
Drosophila melanogaster Dmel_CG9383   anti-silencing factor 1
Echinococcus granulosus EgrG_000439100   histone chaperone asf1 b
Entamoeba histolytica EHI_127360   anti-silencing protein, putative
Echinococcus multilocularis EmuJ_000439100   histone chaperone asf1 b
Giardia lamblia GL50803_33433   Hypothetical protein
Homo sapiens ENSG00000111875   anti-silencing function 1A histone chaperone
Homo sapiens ENSG00000105011   anti-silencing function 1B histone chaperone
Leishmania braziliensis LbrM.20.4140   anti-silencing protein asf 1-like
Leishmania donovani LdBPK_200060.1   histone chaperone ASF1A
Leishmania infantum LinJ.20.0060   anti-silencing protein asf 1-like protein
Leishmania major LmjF.20.0050   anti-silencing protein asf 1-like protein
Leishmania mexicana LmxM.20.0050   anti-silencing protein asf 1-like protein
Loa Loa (eye worm) LOAG_10301   anti-silencing protein
Mus musculus ENSMUSG00000005470   anti-silencing function 1B histone chaperone
Mus musculus ENSMUSG00000019857   anti-silencing function 1A histone chaperone
Neospora caninum NCLIV_003550   hypothetical protein
Oryza sativa 4339550   Os05g0553800
Onchocerca volvulus OVOC10011  
Plasmodium berghei PBANKA_1439400   histone chaperone ASF1, putative
Plasmodium falciparum PF3D7_1224500   histone chaperone ASF1, putative
Plasmodium knowlesi PKNH_1443800   histone chaperone ASF1, putative
Plasmodium vivax PVX_123855   histone chaperone ASF1, putative
Plasmodium yoelii PY04448   asf1 gene product
Saccharomyces cerevisiae YJL115W   nucleosome assembly factor ASF1
Schistosoma japonicum Sjp_0115610   ko:K10753 histone chaperone ASF1, putative
Schistosoma mansoni Smp_033020   anti-silencing protein
Schmidtea mediterranea mk4.004623.00   Histone chaperone asf1
Trypanosoma brucei gambiense Tbg972.1.90   anti-silencing protein ASF 1 like protein, putative
Trypanosoma brucei Tb927.1.630   histone chaperone ASF1A
Trypanosoma congolense TcIL3000_1_170   histone chaperone ASF1A
Trypanosoma cruzi TcCLB.511417.100   Anti-silencing function protein 1 homolog A
Trypanosoma cruzi TcCLB.505999.30   histone chaperone ASF1A
Toxoplasma gondii TGME49_209140   anti-silencing protein, ASF1 family protein
Theileria parva TP02_0786   chromatin assembly protein, putative
Trichomonas vaginalis TVAG_119050   anti-silencing protein, putative

Essentiality

TcCLB.505999.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.630 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.630 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.630 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.1.630 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F10G7.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C03D6.5 Caenorhabditis elegans embryonic lethal wormbase
TGME49_209140 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens anti-silencing function 1A histone chaperone Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0189 0.2626 1
0.0115 0.5386 0.9019
0.0044 0.5 0.5
0.0189 0.2626 1
0.0044 0.5 0.5
0.0189 0.2626 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.505999.30 (Trypanosoma cruzi), histone chaperone ASF1A
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