Detailed view for PF3D7_1206500

Basic information

TDR Targets ID: 5113
Plasmodium falciparum, Tat binding protein 1(TBP-1)-interacting protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.7376 | Length (AA): 651 | MW (Da): 76411 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07106   Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

Gene Ontology

Mouse over links to read term descriptions.
GO:0007131   meiotic recombination  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 143 2ap3 (A) 44 183 24.00 0.94 0.03 0.579426 -1.94
453 506 2mh2 (A) 16 71 46.00 0.0062 1 0.755649 -1.89
435 488 2mh2 (A) 16 71 46.00 0.0059 1 0.757408 -1.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, Female Gametocyte, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_128568)

Species Accession Gene Product
Arabidopsis thaliana AT1G13330   homologous-pairing protein 2-like protein
Brugia malayi Bm1_52545   nuclear receptor coactivator GT198
Candida albicans CaO19.10439   similar to N terminus of Hop2p, meiosis-specific gene required for the pairing of similar chromosomes
Candida albicans CaO19.2922   weak similarity to N terminus of Hop2p, meiosis-specific gene required for the pairing of similar chromosomes
Cryptosporidium hominis Chro.20059   hypothetical protein
Cryptosporidium parvum cgd2_510   hypothetical coiled coil protein
Dictyostelium discoideum DDB_G0280989   hypothetical protein
Echinococcus granulosus EgrG_000450600   ous pairing protein 2
Entamoeba histolytica EHI_000750   TBP interacting protein, putative
Echinococcus multilocularis EmuJ_000450600   ous pairing protein 2
Giardia lamblia GL50803_17044   Hypothetical protein
Homo sapiens ENSG00000131470   PSMC3 interacting protein
Leishmania braziliensis LbrM.27.2630   hypothetical protein, conserved
Leishmania donovani LdBPK_272370.1   hypothetical protein, conserved
Leishmania infantum LinJ.27.2370   hypothetical protein, conserved
Leishmania major LmjF.27.2420   hypothetical protein, conserved
Leishmania mexicana LmxM.27.2420   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00260   hypothetical protein
Mus musculus 19183   proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
Neospora caninum NCLIV_025930   TBPIP domain-containing protein, putative
Plasmodium berghei PBANKA_0605100   Tat binding protein 1(TBP-1)-interacting protein, putative
Plasmodium falciparum PF3D7_1206500   Tat binding protein 1(TBP-1)-interacting protein, putative
Plasmodium knowlesi PKNH_1306500   Tat binding protein 1(TBP-1)-interacting protein, putative
Plasmodium vivax PVX_084360   Tat binding protein 1(TBP-1)-interacting protein, putative
Plasmodium yoelii PY01846   hypothetical protein
Saccharomyces cerevisiae YGL033W   Hop2p
Schistosoma mansoni Smp_068840   tbp-1 interacting protein
Schmidtea mediterranea mk4.002840.00   Putative tbp-1 interacting protein
Trypanosoma brucei gambiense Tbg.972.2.3210   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5190   Homologous-pairing protein 2 homolog
Trypanosoma congolense TcIL3000_2_1290   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507801.110   Tat binding protein 1(TBP-1)-interacting protein (TBPIP), putative
Trypanosoma cruzi TcCLB.511627.130   Tat binding protein 1(TBP-1)-interacting protein (TBPIP), putative
Toxoplasma gondii TGME49_261560   Tat binding protein 1(TBP-1)-interacting protein TBPIP
Trichomonas vaginalis TVAG_058400   meiosis-specific interhomolog recombination protein Hop2A
Trichomonas vaginalis TVAG_151700   meiosis-specific interhomolog recombination protein Hop2B

Essentiality

PF3D7_1206500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.5190 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.5190 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.5190 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.5190 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0605100 Plasmodium berghei Dispensable plasmo
TGME49_261560 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1206500 (Plasmodium falciparum), Tat binding protein 1(TBP-1)-interacting protein, putative
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