Detailed view for PF3D7_0707400

Basic information

TDR Targets ID: 512
Plasmodium falciparum, AAA family ATPase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.9266 | Length (AA): 663 | MW (Da): 78187 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00004   ATPase family associated with various cellular activities (AAA)
PF12037   Domain of unknown function (DUF3523)

Gene Ontology

Mouse over links to read term descriptions.
GO:0017111   nucleoside-triphosphatase activity  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
323 667 1w5s (A) 15 407 11.00 0 1 0.31 0.22
325 596 1in4 (A) 20 272 17.00 0.000026 1 0.53 -0.41
326 652 1in4 (A) 21 325 14.00 0 1 0.48 -0.17
328 625 2dhr (A) 154 444 20.00 0 1 0.63 0.11
328 624 2ce7 (A) 159 465 24.00 0 1 0.64 -0.16
328 573 1ixz (A) 154 393 24.00 0 1 0.61 -0.98
2 81 4zqa (A) 6 85 19.00 0.6 0.03 0.432264 -1.49
3 139 2i1k (A) 303 451 14.00 0.097 0.24 0.394237 -0.84
19 117 4mh6 (A) 48 146 15.00 0.8 0.06 0.396921 -1.22
325 617 4ww0 (A) 154 465 26.00 0.000000049 1 0.650631 0.15
332 502 2ce7 (A) 167 343 35.00 0.000000026 1 0.625619 -0.34
356 478 3whl (A) 216 338 41.00 0.000022 0.99 0.46422 0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 32 hs, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129958)

Species Accession Gene Product
Arabidopsis thaliana AT4G36580   AAA-type ATPase family protein
Arabidopsis thaliana AT5G16930   AAA-type ATPase family protein
Arabidopsis thaliana AT2G18330   AAA-type ATPase-like protein
Arabidopsis thaliana AT3G03060   P-loop containing nucleoside triphosphate hydrolases superfamily protein
Babesia bovis BBOV_III001380   ATPase, AAA family protein
Brugia malayi Bm1_24925   MGC68616 protein
Caenorhabditis elegans CELE_F54B3.3   Protein ATAD-3
Cryptosporidium hominis Chro.70168   26S proteosome regulatory subunit
Cryptosporidium parvum cgd7_1410   AAA domain containing protein
Drosophila melanogaster Dmel_CG6815   belphegor
Echinococcus granulosus EgrG_000242000   ATPase family AAA domain containing protein
Echinococcus multilocularis EmuJ_000242000   ATPase family AAA domain containing protein
Homo sapiens ENSG00000160072   ATPase family, AAA domain containing 3B
Homo sapiens ENSG00000197785   ATPase family, AAA domain containing 3A
Loa Loa (eye worm) LOAG_01798   hypothetical protein
Mus musculus ENSMUSG00000029036   ATPase family, AAA domain containing 3A
Neospora caninum NCLIV_049570   hypothetical protein
Oryza sativa 4330465   Os02g0706500
Oryza sativa 4330409   Os02g0697600
Plasmodium berghei PBANKA_0804600   AAA family ATPase, putative
Plasmodium falciparum PF3D7_0707400   AAA family ATPase, putative
Plasmodium knowlesi PKNH_0105900   AAA family ATPase, putative
Plasmodium vivax PVX_087895   AAA family ATPase, putative
Plasmodium yoelii PY00142   putative 26S proteosome regulatory subunit
Schistosoma japonicum Sjp_0090240   ATPase family AAA domain-containing protein 3-A, putative
Schistosoma japonicum Sjp_0090250   ko:K01516 nucleoside-triphosphatase [EC3.6.1.15], putative
Schistosoma mansoni Smp_167200   ATPase
Schmidtea mediterranea mk4.000127.03   Putative ATPase
Schmidtea mediterranea mk4.000127.02  
Toxoplasma gondii TGME49_234420   ATPase, AAA family protein
Theileria parva TP03_0703   AAA family ATPase, putative

Essentiality

PF3D7_0707400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F54B3.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F54B3.3 Caenorhabditis elegans larval arrest wormbase
CELE_F54B3.3 Caenorhabditis elegans slow growth wormbase
CELE_F54B3.3 Caenorhabditis elegans sterile wormbase
TGME49_234420 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0707400 (Plasmodium falciparum), AAA family ATPase, putative
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