pI: 4.0674 |
Length (AA): 163 |
MW (Da): 18360 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 158 | 1roc (A) | 3 | 154 | 38.00 | 0 | 1 | 1.47 | -1.58 |
7 | 159 | 1tey (A) | 4 | 155 | 36.00 | 0 | 1 | 1.54 | -1.5 |
6 | 158 | 5bnx (D) | 3 | 154 | 36.00 | 0 | 1 | 1.48405 | -1.12 |
6 | 163 | 2idc (A) | 3 | 166 | 38.00 | 0 | 1 | 1.51343 | -0.7 |
6 | 157 | 5eii (I) | 3 | 153 | 39.00 | 0 | 1 | 1.06952 | 0.13 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127499)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G66740 | putative histone chaperone ASF1A |
Arabidopsis thaliana | AT5G38110 | histone chaperone ASF1B |
Babesia bovis | BBOV_III011490 | anti-silencing protein, ASF1-like family protein |
Brugia malayi | Bm1_42255 | Anti-silencing protein, ASF1-like containing protein |
Candida albicans | CaO19.3715 | Component of replication-coupling assembly factor |
Candida albicans | CaO19.11200 | Component of replication-coupling assembly factor |
Caenorhabditis elegans | CELE_C03D6.5 | Protein ASFL-1 |
Caenorhabditis elegans | CELE_F10G7.3 | Protein UNC-85 |
Cryptosporidium hominis | Chro.40095 | asf1 |
Cryptosporidium parvum | cgd4_760 | possible ASF1 anti-silencing function 1 like protein |
Dictyostelium discoideum | DDB_G0285513 | anti-silencing protein 1 |
Drosophila melanogaster | Dmel_CG9383 | anti-silencing factor 1 |
Echinococcus granulosus | EgrG_000439100 | histone chaperone asf1 b |
Entamoeba histolytica | EHI_127360 | anti-silencing protein, putative |
Echinococcus multilocularis | EmuJ_000439100 | histone chaperone asf1 b |
Giardia lamblia | GL50803_33433 | Hypothetical protein |
Homo sapiens | ENSG00000111875 | anti-silencing function 1A histone chaperone |
Homo sapiens | ENSG00000105011 | anti-silencing function 1B histone chaperone |
Leishmania braziliensis | LbrM.20.4140 | anti-silencing protein asf 1-like |
Leishmania donovani | LdBPK_200060.1 | histone chaperone ASF1A |
Leishmania infantum | LinJ.20.0060 | anti-silencing protein asf 1-like protein |
Leishmania major | LmjF.20.0050 | anti-silencing protein asf 1-like protein |
Leishmania mexicana | LmxM.20.0050 | anti-silencing protein asf 1-like protein |
Loa Loa (eye worm) | LOAG_10301 | anti-silencing protein |
Mus musculus | ENSMUSG00000005470 | anti-silencing function 1B histone chaperone |
Mus musculus | ENSMUSG00000019857 | anti-silencing function 1A histone chaperone |
Neospora caninum | NCLIV_003550 | hypothetical protein |
Oryza sativa | 4339550 | Os05g0553800 |
Onchocerca volvulus | OVOC10011 |
|
Plasmodium berghei | PBANKA_1439400 | histone chaperone ASF1, putative |
Plasmodium falciparum | PF3D7_1224500 | histone chaperone ASF1, putative |
Plasmodium knowlesi | PKNH_1443800 | histone chaperone ASF1, putative |
Plasmodium vivax | PVX_123855 | histone chaperone ASF1, putative |
Plasmodium yoelii | PY04448 | asf1 gene product |
Saccharomyces cerevisiae | YJL115W | nucleosome assembly factor ASF1 |
Schistosoma japonicum | Sjp_0115610 | ko:K10753 histone chaperone ASF1, putative |
Schistosoma mansoni | Smp_033020 | anti-silencing protein |
Schmidtea mediterranea | mk4.004623.00 | Histone chaperone asf1 |
Trypanosoma brucei gambiense | Tbg972.1.90 | anti-silencing protein ASF 1 like protein, putative |
Trypanosoma brucei | Tb927.1.630 | histone chaperone ASF1A |
Trypanosoma congolense | TcIL3000_1_170 | histone chaperone ASF1A |
Trypanosoma cruzi | TcCLB.511417.100 | Anti-silencing function protein 1 homolog A |
Trypanosoma cruzi | TcCLB.505999.30 | histone chaperone ASF1A |
Toxoplasma gondii | TGME49_209140 | anti-silencing protein, ASF1 family protein |
Theileria parva | TP02_0786 | chromatin assembly protein, putative |
Trichomonas vaginalis | TVAG_119050 | anti-silencing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.630 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.1.630 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F10G7.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C03D6.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_209140 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | anti-silencing function 1A histone chaperone | Compounds | References |