Detailed view for TcCLB.506211.140

Basic information

TDR Targets ID: 51433
Trypanosoma cruzi, Complex 1 protein (LYR family), putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.9653 | Length (AA): 709 | MW (Da): 83418 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05347   Complex 1 protein (LYR family)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_129478)

Species Accession Gene Product
Arabidopsis thaliana AT3G12260   LYR family of Fe/S cluster biogenesis protein
Candida albicans CaO19.6035   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa CI-14.8KD, mammalian CI-B14 subuni
Candida albicans CaO19.13456   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa CI-14.8KD, mammalian CI-B14 subuni
Caenorhabditis elegans CELE_Y57G11C.12   Protein NUO-3, isoform B
Dictyostelium discoideum DDB_G0291129   NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 6
Drosophila melanogaster Dmel_CG7712   CG7712 gene product from transcript CG7712-RB
Homo sapiens ENSG00000184983   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
Leishmania braziliensis LbrM.19.0540   hypothetical protein, conserved
Leishmania donovani LdBPK_190220.1   Complex 1 protein (LYR family), putative
Leishmania infantum LinJ.19.0220   hypothetical protein, conserved
Leishmania major LmjF.19.0230   hypothetical protein, conserved
Leishmania mexicana LmxM.19.0230   hypothetical protein, conserved
Mus musculus ENSMUSG00000022450   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14)
Oryza sativa 4344058   Os07g0640100
Schistosoma japonicum Sjp_0001890   ko:K03950 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 6, putative
Schmidtea mediterranea mk4.001549.01   NADH dehydrogenase
Schmidtea mediterranea mk4.001203.15   NADH dehydrogenase
Trypanosoma brucei gambiense Tbg972.10.18030   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.14860   NADH-ubiquinone oxidoreductase B14 subunit
Trypanosoma congolense TcIL3000_10_12720   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506211.140   Complex 1 protein (LYR family), putative
Trypanosoma cruzi TcCLB.511289.90   Complex 1 protein (LYR family), putative

Essentiality

TcCLB.506211.140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14860 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14860 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14860 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.14860 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y57G11C.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y57G11C.12 Caenorhabditis elegans larval arrest wormbase
CELE_Y57G11C.12 Caenorhabditis elegans slow growth wormbase
CELE_Y57G11C.12 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.506211.140 (Trypanosoma cruzi), Complex 1 protein (LYR family), putative
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