Detailed view for PF3D7_1209800

Basic information

TDR Targets ID: 5146
Plasmodium falciparum, ATP synthase mitochondrial F1 complex assembly factor 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.9055 | Length (AA): 189 | MW (Da): 23124 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06644   ATP11 protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0065003   macromolecular complex assembly  
GO:0005739   mitochondrion  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 188 2p4f (A) 97 296 19.00 0 1 1.22574 -1.11
31 77 1y13 (A) 56 113 45.00 0.21 0.26 0.336477 1.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Ring. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early trophozoite, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, early schizont. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, merozoite, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, Female Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Oocyst, Sporozoite. Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_128892)

Species Accession Gene Product
Arabidopsis thaliana AT2G34050   ATP11 molecular chaperone domain-containing protein
Babesia bovis BBOV_I000640   conserved hypothetical protein
Candida albicans CaO19_6916   hypothetical protein
Candida albicans CaO19.6916   assembly of F1-ATPase
Dictyostelium discoideum DDB_G0280243   hypothetical protein
Drosophila melanogaster Dmel_CG10340   CG10340 gene product from transcript CG10340-RA
Leishmania braziliensis LbrM.34.1860   hypothetical protein, conserved
Leishmania donovani LdBPK_351940.1   ATP11 protein, putative
Leishmania infantum LinJ.35.1940   hypothetical protein, conserved
Leishmania major LmjF.35.1950   hypothetical protein, conserved
Leishmania mexicana LmxM.34.1950   hypothetical protein, conserved
Mus musculus ENSMUSG00000028710   ATP synthase mitochondrial F1 complex assembly factor 1
Neospora caninum NCLIV_013200   hypothetical protein
Oryza sativa 4329133   Os02g0312700
Plasmodium berghei PBANKA_0608200   ATP synthase mitochondrial F1 complex assembly factor 1, putative
Plasmodium falciparum PF3D7_1209800   ATP synthase mitochondrial F1 complex assembly factor 1, putative
Plasmodium knowlesi PKNH_1309700   ATP synthase mitochondrial F1 complex assembly factor 1, putative
Plasmodium yoelii PY01827   hypothetical protein
Saccharomyces cerevisiae YNL315C   Atp11p
Trypanosoma brucei gambiense Tbg972.9.9430   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.15240   ATP11 protein, putative
Trypanosoma congolense TcIL3000_9_6390   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509671.40   ATP11 protein, putative
Trypanosoma cruzi TcCLB.510767.50   ATP11 protein, putative

Essentiality

PF3D7_1209800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.244.2700 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.244.2700 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.244.2700 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.244.2700 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1209800 (Plasmodium falciparum), ATP synthase mitochondrial F1 complex assembly factor 1, putative
Title for this comment
Comment