pI: 9.5517 |
Length (AA): 441 |
MW (Da): 53327 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
87 | 409 | 2a06 (C) | 25 | 359 | 16.00 | 0.00000076 | 0 | 0.8 | -0.91 |
191 | 272 | 4lua (A) | 55 | 138 | 30.00 | 0.66 | 0.37 | 0.292041 | 1.71 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | merozoite, sporozoite, early schizont, late schizont, late trophozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early trophozoite, Male Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, Oocyst, Sporozoite, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring. | Otto TD Zanghi G |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_128297)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G22130 | GPI mannosyltransferase 1 |
Babesia bovis | BBOV_II000550 | mannosyltransferase (PIG-M) containing domain |
Brugia malayi | Bm1_10780 | mannosyltransferase |
Candida albicans | CaO19.12050 | similar to human angiotensin II type 1b receptor |
Candida albicans | CaO19.4581 | similar to human angiotensin II type 1b receptor |
Caenorhabditis elegans | CELE_B0491.1 | Protein B0491.1 |
Cryptosporidium hominis | Chro.10419 | mannosyltransferase-related |
Cryptosporidium parvum | cgd1_3720 | PIG-M mannosyltransferase,8 transmembrane domain |
Dictyostelium discoideum | DDB_G0288899 | DXD motif-containing protein |
Drosophila melanogaster | Dmel_CG9865 | CG9865 gene product from transcript CG9865-RA |
Echinococcus granulosus | EgrG_000822400 | Mannosyltransferase family protein |
Entamoeba histolytica | EHI_103330 | mannosyltransferase, putative |
Entamoeba histolytica | EHI_029580 | mannosyltransferase, putative |
Echinococcus multilocularis | EmuJ_000822400 | Mannosyltransferase family protein |
Giardia lamblia | GL50803_17502 | Mannosyltransferase |
Homo sapiens | ENSG00000143315 | phosphatidylinositol glycan anchor biosynthesis, class M |
Leishmania braziliensis | LbrM.30.1970 | mannosyltransferase, putative |
Leishmania donovani | LdBPK_302030.1 | mannosyltransferase, putative |
Leishmania infantum | LinJ.30.2030 | mannosyltransferase, putative |
Leishmania major | LmjF.30.2030 | mannosyltransferase, putative |
Leishmania mexicana | LmxM.29.2030 | mannosyltransferase, putative |
Loa Loa (eye worm) | LOAG_02158 | mannosyltransferase |
Loa Loa (eye worm) | LOAG_11656 | hypothetical protein |
Mus musculus | ENSMUSG00000050229 | phosphatidylinositol glycan anchor biosynthesis, class M |
Neospora caninum | NCLIV_054210 | GPI mannosyltransferase 1, putative |
Oryza sativa | 4333686 | Os03g0670200 |
Onchocerca volvulus | OVOC11090 | GPI mannosyltransferase 1 homolog |
Plasmodium berghei | PBANKA_0609300 | GPI mannosyltransferase 1, putative |
Plasmodium falciparum | PF3D7_1210900 | GPI mannosyltransferase 1 |
Plasmodium knowlesi | PKNH_1311000 | GPI mannosyltransferase 1, putative |
Plasmodium vivax | PVX_084575 | GPI mannosyltransferase I, putative |
Plasmodium yoelii | PY02427 | mannosyltransferase-related |
Saccharomyces cerevisiae | YJR013W | Gpi14p |
Schistosoma japonicum | Sjp_0116980 | ko:K05284 phosphatidylinositol glycan, class M, putative |
Schistosoma japonicum | Sjp_0093010 | hypothetical protein |
Schistosoma mansoni | Smp_128810 | hypothetical protein |
Schmidtea mediterranea | mk4.002703.03 | |
Trypanosoma brucei gambiense | Tbg972.6.3090 | mannosyltransferase, putative |
Trypanosoma brucei | Tb927.6.3300 | GPI alpha-mannosyltransferase I |
Trypanosoma congolense | TcIL3000_6_2850 | mannosyltransferase, putative |
Trypanosoma congolense | TcIL3000_6_2840 | GPI transamidase subunit PIG-U, putative |
Trypanosoma cruzi | TcCLB.511507.50 | mannosyltransferase, putative |
Trypanosoma cruzi | TcCLB.503909.100 | mannosyltransferase, putative |
Toxoplasma gondii | TGME49_310100 | mannosyltransferase (pig-m) protein |
Theileria parva | TP04_0525 | mannosyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.3300 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3300 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3300 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.3300 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
YJR013W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0609300 | Plasmodium berghei | Essential | plasmo |
TGME49_310100 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
17 literature references were collected for this gene.