Detailed view for TcCLB.506213.60

Basic information

TDR Targets ID: 51603
Trypanosoma cruzi, 40S ribosomal protein S2, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.4339 | Length (AA): 263 | MW (Da): 28532 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00333   Ribosomal protein S5, N-terminal domain
PF03719   Ribosomal protein S5, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0015935   small ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126722)

Species Accession Gene Product
Arabidopsis thaliana AT3G57490   40S ribosomal protein S2-4
Arabidopsis thaliana AT1G58684   40S ribosomal protein S2-2
Arabidopsis thaliana AT1G58983   40S ribosomal protein S2-2
Arabidopsis thaliana AT2G41840   40S ribosomal protein S2-3
Arabidopsis thaliana AT1G58380   40S ribosomal protein S2-1
Arabidopsis thaliana AT1G59359   40S ribosomal protein S2-2
Arabidopsis thaliana AT2G33800   30S ribosomal protein S5
Babesia bovis BBOV_IV003540   ribosomal protein S2
Brugia malayi Bm1_39350   40S ribosomal protein S2
Candida albicans CaO19.10845   likely cytosolic ribosomal protein similar to S. cerevisiae RPS2 (YGL123W) small subunit protein S2
Candida albicans CaO19.3334   likely cytosolic ribosomal protein similar to S. cerevisiae RPS2 (YGL123W) small subunit protein S2
Caenorhabditis elegans CELE_C49H3.11   Protein RPS-2
Cryptosporidium hominis Chro.40460   ribosomal protein S5
Cryptosporidium parvum cgd4_4020   40S ribosomal protein S2/S5. DSRBD RNA binding domain
Chlamydia trachomatis CT_512   30S ribosomal protein S5
Dictyostelium discoideum DDB_G0293742   ribosomal protein S2
Dictyostelium discoideum DDB_G0293090   hypothetical protein
Drosophila melanogaster Dmel_CG5920   Ribosomal protein S2
Escherichia coli b3303   30S ribosomal subunit protein S5
Echinococcus granulosus EgrG_000726300   40S ribosomal protein S2
Entamoeba histolytica EHI_020280   40S ribosomal protein S2, putative
Echinococcus multilocularis EmuJ_000726300   40S ribosomal protein S2
Giardia lamblia GL50803_8118   Ribosomal protein S2
Homo sapiens ENSG00000140988   ribosomal protein S2
Leishmania braziliensis LbrM.19.0370   40S ribosomal protein S2
Leishmania braziliensis LbrM.32.0520   40S ribosomal protein S2
Leishmania donovani LdBPK_320460.1   40S ribosomal protein S2
Leishmania infantum LinJ.19.0050   40S ribosomal protein S2
Leishmania infantum LinJ.32.0460   40S ribosomal protein S2
Leishmania major LmjF.19.0060   40S ribosomal protein S2
Leishmania major LmjF.32.0450   40S ribosomal protein S2
Leishmania mexicana LmxM.31.0450   40S ribosomal protein S2
Leishmania mexicana LmxM.19.0060   40S ribosomal protein S2
Loa Loa (eye worm) LOAG_02798   40S ribosomal protein S2
Mycobacterium leprae ML1842c   PROBABLE 30S RIBOSOMAL PROTEIN S5 RPSE
Mus musculus 639606   predicted gene 10420
Mus musculus 102642415   40S ribosomal protein S2-like
Mus musculus 620248   predicted gene 6139
Mus musculus ENSMUSG00000044533   ribosomal protein S2
Mycobacterium tuberculosis Rv0721   30S ribosomal protein S5 RpsE
Mycobacterium ulcerans MUL_0811   30S ribosomal protein S5
Neospora caninum NCLIV_044000   hypothetical protein
Oryza sativa 4334512   Os03g0807800
Oryza sativa 4342695   Os07g0207400
Oryza sativa 4333233   Os03g0452300
Plasmodium berghei PBANKA_1310800   40S ribosomal protein S5, putative
Plasmodium falciparum PF3D7_1447000   40S ribosomal protein S5
Plasmodium knowlesi PKNH_1235200   40S ribosomal protein S5, putative
Plasmodium vivax PVX_118145   40S ribosomal protein S5, putative
Plasmodium yoelii PY06704   ribosomal protein S5
Saccharomyces cerevisiae YGL123W   ribosomal 40S subunit protein S2
Schistosoma japonicum Sjp_0304520   ko:K02981 small subunit ribosomal protein S2e, putative
Schistosoma mansoni Smp_013470.1   ribosomal protein S2
Schistosoma mansoni Smp_013470.2   ribosomal protein S2
Schmidtea mediterranea mk4.091311.04  
Schmidtea mediterranea mk4.012968.03   40S ribosomal protein S2
Trypanosoma brucei gambiense Tbg972.10.17870   RPS2,40S ribosomal protein S2, putative
Trypanosoma brucei gambiense Tbg972.10.17750   40S ribosomal protein S2, putative
Trypanosoma brucei Tb927.10.14710   40S ribosomal protein S2, putative
Trypanosoma brucei Tb927.10.14600   40S ribosomal protein S2, putative
Trypanosoma congolense TcIL3000_10_12580   40S ribosomal protein S2, putative
Trypanosoma congolense TcIL3000_10_12490   40S ribosomal protein S2, putative
Trypanosoma cruzi TcCLB.506213.60   40S ribosomal protein S2, putative
Trypanosoma cruzi TcCLB.511287.120   40S ribosomal protein S2, putative
Trypanosoma cruzi TcCLB.511287.40   40S ribosomal protein S2, putative
Trypanosoma cruzi TcCLB.503833.40   40S ribosomal protein S2, putative
Toxoplasma gondii TGME49_305520   ribosomal protein RPS2
Treponema pallidum TP0206   30S ribosomal protein S5
Theileria parva TP02_0780   40S ribosomal protein S2, putative
Trichomonas vaginalis TVAG_162680   40S ribosomal protein S2, putative
Trichomonas vaginalis TVAG_142440   40S ribosomal protein S2, putative
Trichomonas vaginalis TVAG_198100   40S ribosomal protein S2, putative
Trichomonas vaginalis TVAG_483090   40S ribosomal protein S2, putative
Trichomonas vaginalis TVAG_359120   ribosomal S subunit, putative
Wolbachia endosymbiont of Brugia malayi Wbm0324   30S ribosomal protein S5

Essentiality

TcCLB.506213.60 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu733 Mycobacterium tuberculosis essential nmpdr
Tb927.10.14600 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.14600 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14600 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14600 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3303 Escherichia coli essential goodall
CELE_C49H3.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_C49H3.11 Caenorhabditis elegans larval arrest wormbase
CELE_C49H3.11 Caenorhabditis elegans sterile wormbase
YGL123W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1310800 Plasmodium berghei Essential plasmo
TGME49_305520 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.506213.60 (Trypanosoma cruzi), 40S ribosomal protein S2, putative
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