Detailed view for PF3D7_1213600

Basic information

TDR Targets ID: 5182
Plasmodium falciparum, dynein light chain 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.8715 | Length (AA): 93 | MW (Da): 10764 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01221   Dynein light chain type 1

Gene Ontology

Mouse over links to read term descriptions.
GO:0005868   cytoplasmic dynein complex  
GO:0030286   dynein complex  
GO:0005875   microtubule associated complex  
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  
GO:0007017   microtubule-based process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 93 1yo3 (A) 1 83 99.99 0 1 2.26 -2.76
7 93 3rjs (A) 3 89 80.00 0 1 2.05838 -2.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1YO3:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5WOF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, early trophozoite, late trophozoite, Oocyst, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Ring. Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_127498)

Species Accession Gene Product
Arabidopsis thaliana AT4G15930   dynein light chain LC8-type
Babesia bovis BBOV_IV005110   dynein light chain 1, putative
Brugia malayi Bm1_30225   Dynein light chain 1, cytoplasmic
Caenorhabditis elegans CELE_T26A5.9   Protein DLC-1
Cryptosporidium hominis Chro.20085   cut up CG6998-PA
Cryptosporidium parvum cgd2_740   cut up CG6998-PA, putative
Dictyostelium discoideum DDB_G0274815   cytoplasmic dynein light chain
Drosophila melanogaster Dmel_CG6998   cut up
Drosophila melanogaster Dmel_CG5450   Cytoplasmic dynein light chain 2
Echinococcus granulosus EgrG_000433300   dynein light chain
Echinococcus granulosus EgrG_000940900   dynein light chain
Echinococcus granulosus EgrG_000940700   dynein light chain
Echinococcus granulosus EgrG_000071400   dynein light chain
Echinococcus granulosus EgrG_000946900   dnl2 protein
Echinococcus granulosus EgrG_000941000   dynein light chain
Echinococcus granulosus EgrG_000433600   dynein light chain
Echinococcus granulosus EgrG_000967000   Dynein light chain type 1 2
Echinococcus granulosus EgrG_000071300   dynein light chain
Echinococcus granulosus EgrG_000991200   Dynein light chain type 1 2
Echinococcus granulosus EgrG_000104100   dynein light chain
Echinococcus granulosus EgrG_000947000   dynein light chain
Echinococcus granulosus EgrG_000684700   dynein light chain
Echinococcus granulosus EgrG_000991100   dynein light chain
Echinococcus granulosus EgrG_000182400   dynein light chain
Echinococcus granulosus EgrG_000947200   dynein light chain
Echinococcus granulosus EgrG_000941100   dynein light chain
Echinococcus granulosus EgrG_000982000   dynein light chain
Echinococcus granulosus EgrG_001200900   Calcium binding protein
Echinococcus granulosus EgrG_000941200   dynein light chain
Echinococcus granulosus EgrG_001060400   dynein light chain
Echinococcus granulosus EgrG_001049900   dynein light chain
Echinococcus granulosus EgrG_000946800   dynein light chain
Echinococcus granulosus EgrG_000071500   dynein light chain
Echinococcus granulosus EgrG_000071100   dynein light chain
Echinococcus granulosus EgrG_000940800   dynein light chain
Echinococcus granulosus EgrG_000991000   dynein light chain
Echinococcus granulosus EgrG_000940500   dynein light chain
Echinococcus granulosus EgrG_000940600   dynein light chain
Echinococcus granulosus EgrG_001060300   expressed protein
Echinococcus granulosus EgrG_000071700   expressed protein
Echinococcus granulosus EgrG_000590100   dynein light chain
Echinococcus granulosus EgrG_000947100   dynein light chain
Entamoeba histolytica EHI_152250   dynein light chain 1,cytoplasmic, putative
Echinococcus multilocularis EmuJ_000182400   dynein light chain
Echinococcus multilocularis EmuJ_000433300   dynein light chain
Echinococcus multilocularis EmuJ_000967000   Dynein light chain, type 1 2
Echinococcus multilocularis EmuJ_001200900   Calcium binding protein
Echinococcus multilocularis EmuJ_000947100   dynein light chain
Echinococcus multilocularis EmuJ_000071500   dynein light chain
Echinococcus multilocularis EmuJ_000940800   dynein light chain
Echinococcus multilocularis EmuJ_000941100   dynein light chain
Echinococcus multilocularis EmuJ_000947000   dynein light chain
Echinococcus multilocularis EmuJ_000071700   hypothetical protein
Echinococcus multilocularis EmuJ_000946800   dynein light chain
Echinococcus multilocularis EmuJ_000991000   dynein light chain
Echinococcus multilocularis EmuJ_000071300   dynein light chain
Echinococcus multilocularis EmuJ_000940600   dynein light chain
Echinococcus multilocularis EmuJ_001060400   dynein light chain
Echinococcus multilocularis EmuJ_000940500   dynein light chain
Echinococcus multilocularis EmuJ_000947200   dynein light chain
Echinococcus multilocularis EmuJ_000071400   dynein light chain
Echinococcus multilocularis EmuJ_000104100   dynein light chain
Echinococcus multilocularis EmuJ_000433600   dynein light chain
Echinococcus multilocularis EmuJ_000940700   dynein light chain
Echinococcus multilocularis EmuJ_000982000   dynein light chain
Echinococcus multilocularis EmuJ_000941200   dynein light chain
Echinococcus multilocularis EmuJ_000946700   dynein light chain
Echinococcus multilocularis EmuJ_000590100   dynein light chain
Echinococcus multilocularis EmuJ_001049900   dynein light chain
Echinococcus multilocularis EmuJ_000684700   dynein light chain
Echinococcus multilocularis EmuJ_001060300   expressed protein
Echinococcus multilocularis EmuJ_000991200   Dynein light chain, type 1 2
Echinococcus multilocularis EmuJ_000941000   dynein light chain
Echinococcus multilocularis EmuJ_000946900   dnl2 protein
Echinococcus multilocularis EmuJ_000940900   dynein light chain
Giardia lamblia GL50803_9848   Dynein light chain
Homo sapiens ENSG00000088986   dynein, light chain, LC8-type 1
Homo sapiens 140735   dynein, light chain, LC8-type 2
Leishmania braziliensis LbrM.32.0300   dynein light chain, flagellar outer arm, putative
Leishmania donovani LdBPK_320240.1   dynein light chain, flagellar outer arm, putative
Leishmania infantum LinJ.32.0240   dynein light chain, flagellar outer arm, putative
Leishmania major LmjF.32.0230   dynein light chain, flagellar outer arm, putative
Leishmania mexicana LmxM.31.0230   dynein light chain, flagellar outer arm, putative
Loa Loa (eye worm) LOAG_07409   neuronal nitric oxidse synthase inhibitor
Loa Loa (eye worm) LOAG_01243   hypothetical protein
Mus musculus ENSMUSG00000009013   dynein light chain LC8-type 1
Mus musculus ENSMUSG00000020483   dynein light chain LC8-type 2
Neospora caninum NCLIV_006030   dynein light chain, putative
Oryza sativa 9267530   Os06g0492700
Oryza sativa 4327718   Os01g0256400
Plasmodium berghei PBANKA_1429400   dynein light chain 1, putative
Plasmodium falciparum PF3D7_1213600   dynein light chain 1, putative
Plasmodium knowlesi PKNH_1433100   dynein light chain 1, putative
Plasmodium vivax PVX_123370   dynein light chain 1, putative
Plasmodium yoelii PY02016   dynein light chain 1, cytoplasmic
Saccharomyces cerevisiae YDR424C   dynein light chain
Schistosoma japonicum Sjp_0218210   Dynein light chain LC6, flagellar outer arm, putative
Schistosoma japonicum Sjp_0025920   Probable dynein light chain, putative
Schistosoma japonicum Sjp_0307870   ko:K10418 dynein light chain LC8-type, putative
Schistosoma japonicum Sjp_0008630   Dynein light chain LC6, flagellar outer arm, putative
Schistosoma japonicum Sjp_0008620   ko:K10418 dynein light chain LC8-type, putative
Schistosoma japonicum Sjp_0006690   Dynein light chain 1, cytoplasmic, putative
Schistosoma japonicum Sjp_0080420   Dynein light chain LC6, flagellar outer arm, putative
Schistosoma japonicum Sjp_0201980   Probable dynein light chain, putative
Schistosoma japonicum Sjp_0025930   Dynein light chain, putative
Schistosoma japonicum Sjp_0025950   Dynein light chain, putative
Schistosoma japonicum Sjp_0008600   Dynein light chain LC6, flagellar outer arm, putative
Schistosoma japonicum Sjp_0025940   Dynein light chain, putative
Schistosoma japonicum Sjp_0103670   similar to Dynein 8 kDa light chain, flagellar outer arm, putative
Schistosoma japonicum Sjp_0201480   Dynein light chain 2, cytoplasmic, putative
Schistosoma mansoni Smp_095520   dynein light chain
Schistosoma mansoni Smp_040680   cytoplasmic dynein light chain
Schmidtea mediterranea mk4.015458.01   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.004658.00   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.027785.02   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.003839.03  
Schmidtea mediterranea mk4.004547.01   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.000627.02   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.009602.02   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.007055.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.013744.01   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.000932.11   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.011185.02   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.021722.01   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.018681.01   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.003367.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.012411.02  
Schmidtea mediterranea mk4.004385.03   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.000627.05   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.009676.01   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.010818.00   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.000090.18   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.010934.00  
Schmidtea mediterranea mk4.001774.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.005303.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.000933.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.000146.09  
Schmidtea mediterranea mk4.000270.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.013210.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.028118.00   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.004466.00   Probable dynein light chain 2, cytoplasmic
Schmidtea mediterranea mk4.026184.01   Dynein light chain 1, cytoplasmic
Schmidtea mediterranea mk4.022266.00   Dynein light chain 1, cytoplasmic
Trypanosoma brucei gambiense Tbg972.11.700   dynein light chain, putative
Trypanosoma brucei Tb11.0845   dynein light chain LC8, putative
Trypanosoma brucei Tb927.11.18680   dynein light chain LC8, putative
Trypanosoma brucei Tb927.11.715   dynein light chain LC8, putative
Trypanosoma congolense TcIL3000_10_13360   dynein light chain, putative
Trypanosoma cruzi TcCLB.506925.104   dynein light chain, putative
Toxoplasma gondii TGME49_223000   dynein light chain DLC
Theileria parva TP01_0234   dynein light chain 1, putative
Trichomonas vaginalis TVAG_312170   cytoplasmic dynein light chain, putative
Trichomonas vaginalis TVAG_420370   dynein light chain, putative
Trichomonas vaginalis TVAG_134920   cytoplasmic dynein light chain, putative

Essentiality

PF3D7_1213600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.50.0007 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.50.0007 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.50.0007 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.50.0007 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T26A5.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_T26A5.9 Caenorhabditis elegans larval lethal wormbase
CELE_T26A5.9 Caenorhabditis elegans slow growth wormbase
TGME49_223000 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1213600 (Plasmodium falciparum), dynein light chain 1, putative
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