Detailed view for TcCLB.507831.60

Basic information

TDR Targets ID: 51900
Trypanosoma cruzi, heat shock protein 110, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.0244 | Length (AA): 832 | MW (Da): 93526 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00012   Hsp70 protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 629 1yuw (A) 5 554 28.00 0 1 0.88 -0.03
2 390 1ba1 () 5 381 32.00 0 1 0.92 -1.56
5 570 1yuw (A) 8 533 33.00 0 1 1.05 -0.35
617 689 1ud0 (A) 542 612 23.00 0.0000000019 0.06 0.3 -0.24
2 390 3qfu (A) 51 426 32.00 0 1 0.907948 -0.69
2 692 2qxl (A) 3 647 32.00 0 1 1.03943 0.28
3 390 3kvg (A) 21 398 31.00 0 1 0.857246 -0.61
4 692 3c7n (A) 5 647 35.00 0 1 1.19152 -0.02
525 766 3gty (X) 87 329 25.00 0.92 0.76 0.255265 1.43
529 749 5cwo (A) 6 219 11.00 0 0.1 0.365525 -0.65
652 755 1cii (A) 90 201 32.00 0.71 0.1 0.3104 0.66
660 826 4uos (A) 1 165 13.00 0.049 0.05 0.414821 -1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127167)

Species Accession Gene Product
Arabidopsis thaliana AT1G79920   Heat shock protein 70
Arabidopsis thaliana AT1G79930   heat shock protein 91
Arabidopsis thaliana AT1G11660   heat shock protein 70 (Hsp 70) family protein
Babesia bovis BBOV_III004240   dnaK family protein
Brugia malayi Bm1_23190   Hypothetical 86.9 kDa protein C30C11.4 in chromosome III
Candida albicans CaO19.2435   HSP70 family chaperone, HSP90 co-chaperone
Candida albicans CaO19.9971   HSP70 family chaperone, HSP90 co-chaperone
Caenorhabditis elegans CELE_C30C11.4   Protein C30C11.4
Cryptosporidium hominis Chro.40370   heat shock 105kD; heat shock 105kD alpha; heat shock 105kD beta; heat shock 105kDa protein 1
Cryptosporidium parvum cgd4_3270   heat shock 105kD; heat shock 105kD alpha; heat shock 105kD beta; heat shock 105kDa protein 1
Dictyostelium discoideum DDB_G0290187   heat shock protein Hsp70 family protein
Drosophila melanogaster Dmel_CG6603   CG6603 gene product from transcript CG6603-RI
Echinococcus granulosus EgrG_000938600   Heat shock 70 kDa protein 4
Echinococcus granulosus EgrG_000917000   heat shock protein 105
Entamoeba histolytica EHI_197860   heat shock protein 70, putative
Echinococcus multilocularis EmuJ_000938600   Heat shock 70 kDa protein 4
Echinococcus multilocularis EmuJ_000917000   Heat shock 70 kDa protein 4
Homo sapiens ENSG00000120694   heat shock 105kDa/110kDa protein 1
Homo sapiens 22824   heat shock 70kDa protein 4-like
Homo sapiens 3308   heat shock 70kDa protein 4
Leishmania braziliensis LbrM.18.1400   heat shock protein, putative
Leishmania donovani LdBPK_181350.1   heat shock protein, putative
Leishmania infantum LinJ.18.1350   heat shock protein, putative
Leishmania major LmjF.18.1370   heat shock protein, putative
Leishmania mexicana LmxM.18.1370   heat shock protein, putative
Loa Loa (eye worm) LOAG_07269   hypothetical protein
Mus musculus 18415   heat shock protein 4 like
Mus musculus ENSMUSG00000020361   heat shock protein 4
Mus musculus ENSMUSG00000029657   heat shock 105kDa/110kDa protein 1
Neospora caninum NCLIV_061170   hypothetical protein
Oryza sativa 4341853   Os06g0679800
Oryza sativa 4337984   Os05g0181000
Oryza sativa 4325355   Os01g0180800
Plasmodium berghei PBANKA_1219300   heat shock protein 110, putative
Plasmodium falciparum PF3D7_0708800   heat shock protein 110
Plasmodium knowlesi PKNH_0107400   heat shock protein 110, putative
Plasmodium vivax PVX_087970   heat shock protein 110, putative
Plasmodium yoelii PY05063   Plasmodium falciparum CG4
Saccharomyces cerevisiae YPL106C   adenyl-nucleotide exchange factor SSE1
Saccharomyces cerevisiae YBR169C   adenyl-nucleotide exchange factor SSE2
Schistosoma japonicum Sjp_0300270   ko:K09485 heat shock protein 110kDa, putative
Schistosoma mansoni Smp_069130.1   heat shock protein 70
Schistosoma mansoni Smp_069130.2   heat shock protein 70
Schmidtea mediterranea mk4.008248.00  
Schmidtea mediterranea mk4.002898.05  
Schmidtea mediterranea mk4.003731.00  
Schmidtea mediterranea mk4.006397.01   Heat shock 70 kDa protein 4
Schmidtea mediterranea mk4.000732.02   Heat shock 70 kDa protein 4
Schmidtea mediterranea mk4.022460.00   Heat shock 70 kDa protein 4
Trypanosoma brucei gambiense Tbg972.10.15330   heat shock protein, putative
Trypanosoma brucei Tb927.10.12710   heat shock protein 110, putative
Trypanosoma congolense TcIL3000_10_10830   heat shock protein 110, putative
Trypanosoma cruzi TcCLB.507831.60   heat shock protein 110, putative
Toxoplasma gondii TGME49_219310   DnaK family protein
Theileria parva TP02_0243   heat shock protein 110, putative
Trichomonas vaginalis TVAG_107710   heat shock protein 70kD, putative
Trichomonas vaginalis TVAG_479220   heat shock protein, putative
Trichomonas vaginalis TVAG_432010   heat shock protein 70 (HSP70)-4, putative
Trichomonas vaginalis TVAG_139320   heat shock protein, putative
Trichomonas vaginalis TVAG_291920   heat shock protein 70kD, putative
Trichomonas vaginalis TVAG_151620   heat shock protein 70 (HSP70)-4, putative

Essentiality

TcCLB.507831.60 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.12710 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.12710 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.12710 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.12710 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C30C11.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_C30C11.4 Caenorhabditis elegans larval arrest wormbase
CELE_C30C11.4 Caenorhabditis elegans larval lethal wormbase
CELE_C30C11.4 Caenorhabditis elegans slow growth wormbase
TGME49_219310 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Heat shock cognate 71 kDa protein 650 aa 27.1% 683 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.507831.60 (Trypanosoma cruzi), heat shock protein 110, putative
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