Detailed view for PF3D7_1215800

Basic information

TDR Targets ID: 5202
Plasmodium falciparum, conserved Plasmodium protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.3358 | Length (AA): 366 | MW (Da): 43643 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
132 185 3fby (A) 428 482 37.00 0.007 0.02 0.760941 -2.6
132 193 1ux6 (A) 825 891 40.00 0.029 0.12 0.719799 -2.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 24 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Ring, Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129554)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG31803   CG31803 gene product from transcript CG31803-RA
Echinococcus granulosus EgrG_001174900   radial spoke head 9
Echinococcus multilocularis EmuJ_001174900   radial spoke head 9
Giardia lamblia GL50803_17278   Hypothetical protein
Homo sapiens 221421   radial spoke head 9 homolog (Chlamydomonas)
Leishmania braziliensis LbrM.07.0980   hypothetical protein, conserved
Leishmania braziliensis LbrM.33.2770   hypothetical protein, conserved
Leishmania donovani LdBPK_071080.1   hypothetical protein, conserved
Leishmania donovani LdBPK_332630.1   Radial spokehead-like protein, putative
Leishmania infantum LinJ.07.1080   hypothetical protein, conserved
Leishmania infantum LinJ.33.2630   hypothetical protein, conserved
Leishmania major LmjF.07.0930   hypothetical protein, conserved
Leishmania major LmjF.33.2500   hypothetical protein, conserved
Leishmania mexicana LmxM.32.2500   hypothetical protein, conserved
Leishmania mexicana LmxM.07.0930   hypothetical protein, conserved
Mus musculus ENSMUSG00000023966   radial spoke head 9 homolog (Chlamydomonas)
Neospora caninum NCLIV_028740   hypothetical protein, conserved
Plasmodium berghei PBANKA_1431500   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1215800   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1435300   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_123470   hypothetical protein, conserved
Plasmodium yoelii PY02273   Homo sapiens dJ261G23.2.2
Schistosoma japonicum Sjp_0065950   Conserved hypothetical protein
Schistosoma mansoni Smp_001610   hypothetical protein
Schmidtea mediterranea mk4.000013.29   Radial spoke head protein 9 homolog
Schmidtea mediterranea mk4.000013.28   Radial spoke head protein 9 homolog
Schmidtea mediterranea mk4.002824.02   Radial spoke head protein 9 homolog
Trypanosoma brucei gambiense Tbg972.11.2780   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.8.430   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.2540   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.810   radial spoke protein RSP9, putative
Trypanosoma congolense TcIL3000_8_380   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507649.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.504153.200   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510861.30   hypothetical protein, conserved
Toxoplasma gondii TGME49_255200   Radial spoke head protein 9, putative
Trichomonas vaginalis TVAG_149010   conserved hypothetical protein
Trichomonas vaginalis TVAG_463090   conserved hypothetical protein

Essentiality

PF3D7_1215800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.0140 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.0140 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.0140 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.0140 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.810 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.810 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.810 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.8.810 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1431500 Plasmodium berghei Dispensable plasmo
TGME49_255200 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1215800 (Plasmodium falciparum), conserved Plasmodium protein, unknown function
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