Detailed view for TcCLB.453445.10

Basic information

TDR Targets ID: 52465
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.1723 | Length (AA): 147 | MW (Da): 15937 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 147 4p29 (A) 53 193 11.00 0 0.03 1.1135 -0.62
20 51 1kbh (B) 48 79 47.00 0.3 0.29 0.887987 -1.79
81 127 5uvg (A) 142 342 50.00 0.38 0.07 0.531028 -0.12
106 143 2lqt (A) 14 51 18.00 0.000039 0.54 0.586003 -1.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127883)

Species Accession Gene Product
Arabidopsis thaliana AT5G09570   Cox19-like CHCH family protein
Arabidopsis thaliana AT5G64400   hypothetical protein
Brugia malayi Bm1_57080   Hypothetical 15.4 kDa protein C16C10.11 in chromosome III
Candida albicans CaO19.93   similar to S. cerevisiae YMR002W
Candida albicans CaO19.7739   similar to S. cerevisiae YMR002W
Caenorhabditis elegans CELE_C16C10.11   Protein HAR-1
Dictyostelium discoideum DDB_G0293410   hypothetical protein
Dictyostelium discoideum DDB_G0293382   hypothetical protein
Drosophila melanogaster Dmel_CG5010   CG5010 gene product from transcript CG5010-RA
Drosophila melanogaster Dmel_CG31007   CG31007 gene product from transcript CG31007-RA
Echinococcus granulosus EgrG_000248500   coiled coil helix coiled coil helix
Echinococcus multilocularis EmuJ_000248500   coiled coil helix coiled coil helix
Homo sapiens ENSG00000250479   coiled-coil-helix-coiled-coil-helix domain containing 10
Homo sapiens ENSG00000106153   coiled-coil-helix-coiled-coil-helix domain containing 2
Leishmania braziliensis LbrM.04.0870   hypothetical protein, conserved
Leishmania infantum LinJ.04.0670   hypothetical protein, conserved
Leishmania major LmjF.04.0670   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_10317   HemiAsterlin Resistant family member
Mus musculus 433806   predicted gene 13202
Mus musculus 102641790   coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial-like
Mus musculus ENSMUSG00000070493   coiled-coil-helix-coiled-coil-helix domain containing 2
Mus musculus ENSMUSG00000049422   coiled-coil-helix-coiled-coil-helix domain containing 10
Neospora caninum NCLIV_013700   CHCH domain-containing protein, putative
Oryza sativa 4333749   Os03g0685500
Oryza sativa 4352903   Os12g0637900
Plasmodium berghei PBANKA_1449500   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1234900   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1454300   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_100695   CHCH domain containing protein
Plasmodium yoelii PY00507   hypothetical protein
Saccharomyces cerevisiae YMR002W   Mix17p
Schistosoma japonicum Sjp_0037740   Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial precursor, putative
Schistosoma mansoni Smp_007300   hypothetical protein
Schmidtea mediterranea mk4.023128.00  
Schmidtea mediterranea mk4.003173.01  
Trypanosoma brucei gambiense Tbg972.9.4350   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.7980   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_9_2720   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508137.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.453445.10   hypothetical protein, conserved
Toxoplasma gondii TGME49_213940   CHCH domain-containing protein

Essentiality

TcCLB.453445.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.0040 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.0040 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.0040 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.0040 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_213940 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.453445.10 (Trypanosoma cruzi), hypothetical protein, conserved
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