Detailed view for TcCLB.504881.50

Basic information

TDR Targets ID: 52646
Trypanosoma cruzi, ABC transporter, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0084 | Length (AA): 1728 | MW (Da): 194245 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 13

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF12698   ABC-2 family transporter protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0042626   ATPase activity, coupled to transmembrane movement of substances  
GO:0016021   integral to membrane  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  
GO:0017111   nucleoside-triphosphatase activity  
GO:0016887   ATPase activity  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
615 862 1jj7 (A) 492 742 19.00 0 1 0.3 -0.47
625 985 1z47 (A) 12 355 22.00 0 1 0.3 -0.03
627 860 1vpl (A) 3 233 29.00 0 1 0.62 -1.21
627 985 1oxx (K) 3 352 20.00 0 0.99 0.34 -0.23
1412 1649 1g6h (A) 4 257 20.00 0 1 0.33 -0.74
1414 1661 1vpl (A) 2 239 31.00 0 1 0.49 -1.03
1414 1719 2awn (C) 2 301 22.00 0 1 0.3 0.45
1416 1637 1vpl (A) 4 225 33.00 0 1 0.67 -1.25
507 1636 4f4c (A) 313 1305 20.00 0 1 0.459235 2.05
646 679 5nkm (B) 75 108 44.00 0.31 0.07 0.341676 1.13
1413 1671 4yer (A) 2 296 37.00 0 1 0.580884 -0.43
1416 1633 4p32 (A) 4 224 32.00 0 1 0.595157 -0.81
1420 1727 3d31 (A) 6 302 22.00 0 1 0.353841 0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126568)

Species Accession Gene Product
Arabidopsis thaliana AT3G47780   ABC transporter A family member 7
Arabidopsis thaliana AT2G41700   ABC transporter A family member 1
Arabidopsis thaliana AT3G47770   ABC transporter A family member 6
Arabidopsis thaliana AT5G61690   ABC transporter A family member 11
Arabidopsis thaliana AT5G61740   ABC transporter A family member 10
Arabidopsis thaliana AT3G47740   ABC transporter A family member 3
Arabidopsis thaliana AT3G47730   ABC transporter A family member 2
Arabidopsis thaliana AT5G61730   ABC transporter A family member 9
Arabidopsis thaliana AT3G47750   ABC transporter A family member 4
Arabidopsis thaliana AT5G61700   ABC transporter A family member 12
Arabidopsis thaliana AT3G47760   ABC transporter A family member 5
Arabidopsis thaliana AT3G47790   ABC transporter A family member 8
Brugia malayi Bm1_33910   ABC transporter family protein
Brugia malayi Bm1_48200   ABC transporter family protein
Caenorhabditis elegans CELE_Y53C10A.9   Protein ABT-5
Caenorhabditis elegans CELE_Y39D8C.1   Protein ABT-4
Caenorhabditis elegans CELE_F12B6.1   Protein ABT-2
Caenorhabditis elegans CELE_C48B4.4   Protein CED-7, isoform A
Dictyostelium discoideum DDB_G0271138   ABC transporter A family protein
Dictyostelium discoideum DDB_G0291245   ABC transporter A family protein
Dictyostelium discoideum DDB_G0293436   ABC transporter A family protein
Dictyostelium discoideum DDB_G0274119   ABC transporter A family protein
Dictyostelium discoideum DDB_G0271140   ABC transporter A family protein
Dictyostelium discoideum DDB_G0291994   ABC transporter A family protein
Dictyostelium discoideum DDB_G0267438   ABC transporter A family protein
Dictyostelium discoideum DDB_G0291980   ABC transporter A family protein
Dictyostelium discoideum DDB_G0275453   ABC transporter A family protein
Dictyostelium discoideum DDB_G0274121   ABC transporter A family protein
Drosophila melanogaster Dmel_CG42816   CG42816 gene product from transcript CG42816-RB
Drosophila melanogaster Dmel_CG6052   CG6052 gene product from transcript CG6052-RA
Drosophila melanogaster Dmel_CG31731   CG31731 gene product from transcript CG31731-RB
Drosophila melanogaster Dmel_CG34120   CG34120 gene product from transcript CG34120-RE
Drosophila melanogaster Dmel_CG1718   CG1718 gene product from transcript CG1718-RB
Drosophila melanogaster Dmel_CG42815   CG42815 gene product from transcript CG42815-RA
Drosophila melanogaster Dmel_CG8908   CG8908 gene product from transcript CG8908-RE
Escherichia coli b0127   putative ABC superfamily transporter ATP-binding subunit
Escherichia coli b0794   putative transporter subunit of ABC superfamily: ATP-binding component
Echinococcus granulosus EgrG_000519900   ATP binding cassette sub family A
Entamoeba histolytica EHI_197670   ABC transporter, putative
Entamoeba histolytica EHI_112010   ABC transporter, putative
Echinococcus multilocularis EmuJ_000519900   ATP binding cassette sub family A
Giardia lamblia GL50803_3470   ABC transporter family protein
Giardia lamblia GL50803_16575   ABC transporter family protein
Giardia lamblia GL50803_8227   ATP-binding cassette protein 5
Giardia lamblia GL50803_92223   ABC transporter family protein
Homo sapiens ENSG00000154265   ATP-binding cassette, sub-family A (ABC1), member 5
Homo sapiens ENSG00000107331   ATP-binding cassette, sub-family A (ABC1), member 2
Homo sapiens ENSG00000144452   ATP-binding cassette, sub-family A (ABC1), member 12
Homo sapiens ENSG00000179869   ATP-binding cassette, sub-family A (ABC1), member 13
Homo sapiens ENSG00000064687   ATP-binding cassette, sub-family A (ABC1), member 7
Homo sapiens ENSG00000198691   ATP-binding cassette, sub-family A (ABC1), member 4
Homo sapiens ENSG00000141338   ATP-binding cassette, sub-family A (ABC1), member 8
Homo sapiens ENSG00000154258   ATP-binding cassette, sub-family A (ABC1), member 9
Homo sapiens ENSG00000167972   ATP-binding cassette, sub-family A (ABC1), member 3
Homo sapiens ENSG00000154262   ATP-binding cassette, sub-family A (ABC1), member 6
Homo sapiens ENSG00000154263   ATP-binding cassette, sub-family A (ABC1), member 10
Homo sapiens ENSG00000165029   ATP-binding cassette, sub-family A (ABC1), member 1
Leishmania braziliensis LbrM.15.0820   ABC1 transporter-like protein
Leishmania braziliensis LbrM.29.0630   ABC transporter, putative
Leishmania braziliensis LbrM.11.1020   ABC transporter, putative
Leishmania braziliensis LbrM.27.1050   ABC transporter, putative
Leishmania braziliensis LbrM.11.1000   ABC1 transporter, putative
Leishmania braziliensis LbrM.11.0960   ABC transporter, putative
Leishmania braziliensis LbrM.11.1040   ABC transporter, putative
Leishmania braziliensis LbrM.11.1010   ABC1 transporter, putative
Leishmania braziliensis LbrM.02.0350   ABC1 transporter, putative
Leishmania donovani LdBPK_111210.1   ATP-binding cassette protein subfamily A, member 2, putative
Leishmania donovani LdBPK_111280.1   ATP-binding cassette protein subfamily A, member 6, putative
Leishmania donovani LdBPK_020270.1   ABC1 transporter, putative
Leishmania donovani LdBPK_150800.1   ATP-binding cassette protein subfamily A, member 7, putative
Leishmania donovani LdBPK_290640.1   ATP-binding cassette protein subfamily A, member 10, putative
Leishmania donovani LdBPK_270840.1   ATP-binding cassette protein subfamily A, member 9, putative
Leishmania donovani LdBPK_111260.1   ATP-binding cassette protein subfamily A, member 5, putative
Leishmania infantum LinJ.02.0270   ABC1 transporter, putative
Leishmania infantum LinJ.11.1230   ATP-binding cassette protein subfamily A, member 3, putative
Leishmania infantum LinJ.11.1240   ATP-binding cassette protein subfamily A, member 4, putative
Leishmania infantum LinJ.11.1260   ATP-binding cassette protein subfamily A, member 5, putative
Leishmania infantum LinJ.11.1210   ATP-binding cassette protein subfamily A, member 2, putative
Leishmania infantum LinJ.29.0640   ATP-binding cassette protein subfamily A, member 10, putative,ABC transporter, putative
Leishmania infantum LinJ.27.0840   ATP-binding cassette protein subfamily A, member 9, putative
Leishmania infantum LinJ.11.1280   ATP-binding cassette protein subfamily A, member 6, putative
Leishmania infantum LinJ.27.0830   ATP-binding cassette protein subfamily A, member 8, putative
Leishmania infantum LinJ.11.1220   ABC transporter-like protein
Leishmania major LmjF.15.0760   ATP-binding cassette protein subfamily A, member 7, putative
Leishmania major LmjF.11.1290   ATP-binding cassette protein subfamily A, member 6, putative
Leishmania major LmjF.27.0980   ATP-binding cassette protein subfamily A, member 9, putative
Leishmania major LmjF.11.1250   ATP-binding cassette protein subfamily A, member 4, putative
Leishmania major LmjF.11.1270   ATP-binding cassette protein subfamily A, member 5, putative
Leishmania major LmjF.11.1240   ATP-binding cassette protein subfamily A, member 3, putative
Leishmania major LmjF.11.1220   ATP-binding cassette protein subfamily A, member 2, putative
Leishmania major LmjF.02.0300   ATP-binding cassette subfamily A, member 1, putative
Leishmania major LmjF.29.0620   ATP-binding cassette protein subfamily A, member 10, putative,ABC transporter, putative
Leishmania major LmjF.27.0970   ATP-binding cassette protein subfamily A, member 8, putative
Leishmania mexicana LmxM.11.1250   ATP-binding cassette protein subfamily A, member 4, putative
Leishmania mexicana LmxM.15.0760   ABC1 transporter-like protein
Leishmania mexicana LmxM.11.1270   ABC transporter, putative
Leishmania mexicana LmxM.27.0980   ATP-binding cassette protein subfamily A, member 9, putative
Leishmania mexicana LmxM.11.1220a  
Leishmania mexicana LmxM.27.0970   ABC transporter, putative
Leishmania mexicana LmxM.11.1220   ATP-binding cassette protein subfamily A, member 2, putative
Leishmania mexicana LmxM.11.1240   ABC1 transporter, putative
Leishmania mexicana LmxM.02.0300   ABC1 transporter, putative
Leishmania mexicana LmxM.08_29.0620   ABC transporter, putative
Leishmania mexicana LmxM.11.1290   ABC transporter, putative
Loa Loa (eye worm) LOAG_07764   RIM ABC transporter
Loa Loa (eye worm) LOAG_01727   hypothetical protein
Loa Loa (eye worm) LOAG_00011   hypothetical protein
Loa Loa (eye worm) LOAG_01325   RIM ABC transporter
Loa Loa (eye worm) LOAG_09131   hypothetical protein
Loa Loa (eye worm) LOAG_00012   hypothetical protein
Loa Loa (eye worm) LOAG_00013   hypothetical protein
Mycobacterium leprae ML0590c   Possible unidentified antibiotic-transport ATP-binding protein ABC transporter
Mycobacterium leprae ML2352c   PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA
Mus musculus ENSMUSG00000026944   ATP-binding cassette, sub-family A (ABC1), member 2
Mus musculus ENSMUSG00000035722   ATP-binding cassette, sub-family A (ABC1), member 7
Mus musculus ENSMUSG00000044749   ATP-binding cassette, sub-family A (ABC1), member 6
Mus musculus ENSMUSG00000041797   ATP-binding cassette, sub-family A (ABC1), member 9
Mus musculus ENSMUSG00000054746   ATP-binding cassette, sub-family A (ABC1), member 15
Mus musculus ENSMUSG00000024130   ATP-binding cassette, sub-family A (ABC1), member 3
Mus musculus ENSMUSG00000062017   ATP-binding cassette, sub-family A (ABC1), member 14
Mus musculus ENSMUSG00000020620   ATP-binding cassette, sub-family A (ABC1), member 8b
Mus musculus ENSMUSG00000050296   ATP-binding cassette, sub-family A (ABC1), member 12
Mus musculus ENSMUSG00000051900   ATP-binding cassette, sub-family A (ABC1), member 16
Mus musculus ENSMUSG00000035435   ATP-binding cassette, sub-family A (ABC1), member 17
Mus musculus ENSMUSG00000015243   ATP-binding cassette, sub-family A (ABC1), member 1
Mus musculus ENSMUSG00000018800   ATP-binding cassette, sub-family A (ABC1), member 5
Mus musculus ENSMUSG00000028125   ATP-binding cassette, sub-family A (ABC1), member 4
Mus musculus ENSMUSG00000041828   ATP-binding cassette, sub-family A (ABC1), member 8a
Mus musculus ENSMUSG00000004668   ATP-binding cassette, sub-family A (ABC1), member 13
Mycobacterium tuberculosis Rv2936   Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Mycobacterium tuberculosis Rv1458c   Probable unidentified antibiotic-transport ATP-binding protein ABC transporter
Mycobacterium tuberculosis Rv2688c   Antibiotic-transport ATP-binding protein ABC transporter
Mycobacterium ulcerans MUL_2014   daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA
Mycobacterium ulcerans MUL_1859   antibiotic ABC transporter ATP-binding protein
Mycobacterium ulcerans MUL_3577   ABC transporter ATP-binding protein
Mycobacterium ulcerans MUL_4925   ABC transporter ATP-binding protein
Oryza sativa 9269712   Os09g0360900
Oryza sativa 4345498   Os08g0398300
Oryza sativa 4341405   Os06g0589300
Oryza sativa 9269177   Os08g0398350
Oryza sativa 4328702   Os02g0211000
Oryza sativa 4345497   Os08g0398000
Onchocerca volvulus OVOC1131  
Onchocerca volvulus OVOC2635  
Schistosoma japonicum Sjp_0045340   Retinal-specific ATP-binding cassette transporter, putative
Schistosoma japonicum Sjp_0066190   hypothetical protein
Schistosoma japonicum Sjp_0131960   ko:K05313 glutamate receptor, ionotropic, invertebrate, putative
Schistosoma japonicum Sjp_0045330   ko:K05641 ATP-binding cassette, subfamily A (ABC1), member 1, putative
Schistosoma japonicum Sjp_0045320   ATP-binding cassette sub-family A member 7, putative
Schistosoma mansoni Smp_165800   ATP-binding cassette transporter
Schistosoma mansoni Smp_056290   hypothetical protein
Schmidtea mediterranea mk4.021331.00  
Schmidtea mediterranea mk4.000387.03   ATP-binding cassette sub-family A member 3
Schmidtea mediterranea mk4.000064.03  
Schmidtea mediterranea mk4.000064.16  
Schmidtea mediterranea mk4.006329.01  
Schmidtea mediterranea mk4.000574.05  
Schmidtea mediterranea mk4.000574.02  
Schmidtea mediterranea mk4.004625.02  
Schmidtea mediterranea mk4.009812.00  
Schmidtea mediterranea mk4.000064.04  
Schmidtea mediterranea mk4.002984.00  
Schmidtea mediterranea mk4.000387.01  
Schmidtea mediterranea mk4.000411.03  
Schmidtea mediterranea mk4.001335.01  
Schmidtea mediterranea mk4.003586.01  
Schmidtea mediterranea mk4.000574.04  
Schmidtea mediterranea mk4.000862.03  
Schmidtea mediterranea mk4.000033.05  
Trypanosoma brucei gambiense Tbg972.11.6880   ABC transporter, putative
Trypanosoma brucei gambiense Tbg972.3.4040   ABC transporter, putative
Trypanosoma brucei Tb11.v5.0780   ABC transporter, putative
Trypanosoma brucei Tb927.11.6120   ABC transporter, putative
Trypanosoma brucei Tb927.3.3730   ABC transporter, putative
Trypanosoma congolense TcIL3000.11.6660   ABC transporter, putative
Trypanosoma congolense TcIL3000_3_2420   ABC transporter, putative
Trypanosoma congolense TcIL3000.11.6640   ABC transporter, putative
Trypanosoma cruzi TcCLB.510149.80   ABC transporter, putative
Trypanosoma cruzi TcCLB.506989.30   ABC transporter, putative
Trypanosoma cruzi TcCLB.507099.80   ABC transporter, putative
Trypanosoma cruzi TcCLB.510045.20   ABC transporter, putative
Trypanosoma cruzi TcCLB.503573.9   ATP-binding cassette transporter ABCA1, putative
Trypanosoma cruzi TcCLB.504881.50   ABC transporter, putative
Trypanosoma cruzi TcCLB.504149.20   ATP-binding cassette transporter ABCA1, putative
Treponema pallidum TP0881   ABC transporter, ATP-binding protein (natA)
Trichomonas vaginalis TVAG_274600   ABC transporter, putative
Trichomonas vaginalis TVAG_415980   abca7, putative
Trichomonas vaginalis TVAG_225860   ABC transporter, putative
Trichomonas vaginalis TVAG_117420   abca1, putative
Trichomonas vaginalis TVAG_461460   ABC transporter, putative
Trichomonas vaginalis TVAG_006570   ABC transporter, putative
Trichomonas vaginalis TVAG_208810   abca5, putative
Trichomonas vaginalis TVAG_222590   ABC transporter, putative
Trichomonas vaginalis TVAG_132360   ABC transporter, putative
Trichomonas vaginalis TVAG_178220   abca4, putative
Trichomonas vaginalis TVAG_173120   abca9, putative
Trichomonas vaginalis TVAG_245220   ABC transporter, putative
Trichomonas vaginalis TVAG_367650   ABC transporter, putative
Trichomonas vaginalis TVAG_024550   ABC transporter, putative
Trichomonas vaginalis TVAG_275420   ABC transporter, putative
Trichomonas vaginalis TVAG_059100   abca6, putative
Trichomonas vaginalis TVAG_225870   abca2, putative
Trichomonas vaginalis TVAG_033260   conserved hypothetical protein
Trichomonas vaginalis TVAG_222600   ABC transporter, putative
Trichomonas vaginalis TVAG_151030   abca10, putative
Trichomonas vaginalis TVAG_064700   ABC transporter, putative
Trichomonas vaginalis TVAG_218950   conserved hypothetical protein
Trichomonas vaginalis TVAG_225890   Phosphonates import ATP-binding protein phnC, putative
Trichomonas vaginalis TVAG_064710   ABC transporter, putative
Trichomonas vaginalis TVAG_072430   ABC transporter, putative
Trichomonas vaginalis TVAG_461330   ABC transporter, putative
Trichomonas vaginalis TVAG_033020   abca6, putative
Trichomonas vaginalis TVAG_415970   abca1, putative
Trichomonas vaginalis TVAG_478620   ABC transporter, putative
Trichomonas vaginalis TVAG_432320   abca12, putative
Trichomonas vaginalis TVAG_367660   ABC transporter, putative
Trichomonas vaginalis TVAG_510260   ABC transporter, putative
Trichomonas vaginalis TVAG_006590   abca2, putative
Trichomonas vaginalis TVAG_072420   conserved hypothetical protein
Trichomonas vaginalis TVAG_353220   ABC transporter, putative
Trichomonas vaginalis TVAG_461030   abca6, putative
Trichomonas vaginalis TVAG_225880   abca2, putative
Trichomonas vaginalis TVAG_160130   abca5, putative
Trichomonas vaginalis TVAG_299600   ABC transporter, putative
Trichomonas vaginalis TVAG_432310   abca4, putative
Trichomonas vaginalis TVAG_245200   ABC transporter, putative
Trichomonas vaginalis TVAG_440500   ABC transporter, putative
Trichomonas vaginalis TVAG_254060   metal ABC transporter, putative
Trichomonas vaginalis TVAG_006580   ATP binding cassete (ABC) transporter, putative
Trichomonas vaginalis TVAG_006600   abca8, putative
Trichomonas vaginalis TVAG_419370   abca12, putative
Trichomonas vaginalis TVAG_160140   abca1, putative
Trichomonas vaginalis TVAG_419360   conserved hypothetical protein
Trichomonas vaginalis TVAG_045530   ABC transporter, putative
Trichomonas vaginalis TVAG_461020   ABC transporter, putative
Trichomonas vaginalis TVAG_440490   ABC transporter, putative
Trichomonas vaginalis TVAG_364970   ABC transporter, putative
Trichomonas vaginalis TVAG_072410   conserved hypothetical protein
Trichomonas vaginalis TVAG_248260   ATP binding cassete (ABC) transporter, putative
Trichomonas vaginalis TVAG_136030   ABC transporter, putative
Trichomonas vaginalis TVAG_481000   ABC transporter, putative

Essentiality

TcCLB.504881.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2984 Mycobacterium tuberculosis non-essential nmpdr
mtu2734 Mycobacterium tuberculosis non-essential nmpdr
Tb927.3.3730 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.3730 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.3730 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.3730 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.02.3950 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3950 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3950 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3950 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0127 Escherichia coli non-essential goodall
b0794 Escherichia coli non-essential goodall
CELE_F12B6.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus ATP-binding cassette, sub-family A (ABC1), member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0002 1 1
0.0002 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.504881.50 (Trypanosoma cruzi), ABC transporter, putative
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