Detailed view for PKNH_0901300

Basic information

TDR Targets ID: 527055
Plasmodium knowlesi, casein kinase II beta chain, putative
Source Database / ID: 

pI: 8.6339 | Length (AA): 244 | MW (Da): 27975 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01214   Casein kinase II regulatory subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0005956   protein kinase CK2 complex  
GO:0019887   protein kinase regulator activity  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 222 4dgl (A) 8 215 36.00 0 1 1.29807 -0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126846)

Species Accession Gene Product
Arabidopsis thaliana AT3G60250   casein kinase 2 subunit beta-3
Arabidopsis thaliana AT5G47080   casein kinase 2 subunit beta
Arabidopsis thaliana AT4G17640   casein kinase II beta chain 2
Arabidopsis thaliana AT2G44680   casein kinase II beta subunit 4
Babesia bovis BBOV_II006230   protein kinase CK2 regulatory subunit CK2B1
Babesia bovis BBOV_IV008950   casein kinase II beta 4 subunit, putative
Brugia malayi Bm1_48865   Csnk2b protein
Candida albicans CaO19.9650   Casein kinase II, regulatory (beta) subunit
Candida albicans CaO19.4297   Casein kinase II, regulatory (beta-prime) subunit
Candida albicans CaO19.11773   Casein kinase II, regulatory (beta-prime) subunit
Candida albicans CaO19.2102   Casein kinase II, regulatory (beta) subunit
Caenorhabditis elegans CELE_T01G9.6   Protein KIN-10, isoform A
Cryptosporidium hominis Chro.30219   protein kinase Ck2-beta
Cryptosporidium parvum cgd3_3670   putative protein kinase CK2 regulatory subunit CK2B1
Cryptosporidium parvum cgd3_1850   putative casein kinase II regulatory subunit; besthit Pf 23508244
Dictyostelium discoideum DDB_G0284601   hypothetical protein
Drosophila melanogaster Dmel_CG15224   Casein kinase II beta subunit
Drosophila melanogaster Dmel_CG8914   Casein kinase II beta2 subunit
Echinococcus granulosus EgrG_000924900   casein kinase ii subunit beta
Entamoeba histolytica EHI_152350   casein kinase II regulatory subunit family protein
Entamoeba histolytica EHI_030840   casein kinase II regulatory subunit family protein
Entamoeba histolytica EHI_075700   casein kinase II regulatory subunit family protein
Echinococcus multilocularis EmuJ_000924900   casein kinase ii subunit beta
Giardia lamblia GL50803_7421   Casein kinase II beta chain
Homo sapiens ENSG00000204435   casein kinase 2, beta polypeptide
Leishmania braziliensis LbrM.35.5340   protein kinase ck2 regulatory subunit, putative
Leishmania donovani LdBPK_365320.1   Casein kinase II subunit beta, putative
Leishmania infantum LinJ.36.5320   protein kinase ck2 regulatory subunit, putative
Leishmania major LmjF.36.5090   protein kinase ck2 regulatory subunit, putative
Leishmania mexicana LmxM.36.5090   protein kinase ck2 regulatory subunit, putative
Loa Loa (eye worm) LOAG_02447   Csnk2b protein
Mus musculus ENSMUSG00000024387   casein kinase 2, beta polypeptide
Neospora caninum NCLIV_034900   casein kinase II beta chain, putative
Neospora caninum NCLIV_037540   YOR039Wp-like protein, related
Oryza sativa 4349414   Os10g0564900
Oryza sativa 4343287   Os07g0495100
Onchocerca volvulus OVOC920   Casein kinase II subunit beta homolog
Onchocerca volvulus OVOC915   Casein kinase II subunit beta homolog
Plasmodium berghei PBANKA_0943200   casein kinase II beta chain, putative
Plasmodium berghei PBANKA_1355500   casein kinase II beta chain, putative
Plasmodium falciparum PF3D7_1342400   casein kinase II beta chain
Plasmodium falciparum PF3D7_1103700   casein kinase II beta chain
Plasmodium knowlesi PKNH_1259000   casein kinase II beta chain, putative
Plasmodium knowlesi PKNH_0901300   casein kinase II beta chain, putative
Plasmodium vivax PVX_090870   casein kinase II beta chain, putative
Plasmodium vivax PVX_083020   casein kinase II beta chain, putative
Plasmodium yoelii PY01577   casein kinase ii beta chain
Plasmodium yoelii PY01939   protein kinase Ck2-beta
Saccharomyces cerevisiae YOR039W   casein kinase 2 regulatory subunit CKB2
Saccharomyces cerevisiae YGL019W   casein kinase 2 regulatory subunit CKB1
Schistosoma japonicum Sjp_0021650   ko:K03115 casein kinase 2, beta polypeptide, putative
Schistosoma japonicum Sjp_0203930   ko:K03115 casein kinase 2, beta polypeptide, putative
Schistosoma japonicum Sjp_0049900   Casein kinase II subunit beta, putative
Schistosoma mansoni Smp_025010   casein kinase II beta subunit
Schmidtea mediterranea mk4.000967.04   Casein kinase II subunit beta
Schmidtea mediterranea mk4.000448.08   Casein kinase II subunit beta
Trypanosoma brucei gambiense Tbg972.11.12130   protein kinase ck2 regulatory subunit, putative
Trypanosoma brucei Tb927.11.10820   Casein kinase II subunit beta, putative
Trypanosoma congolense TcIL3000.11.11480   Casein kinase II subunit beta, putative
Trypanosoma cruzi TcCLB.503757.40   Casein kinase II subunit beta, putative
Trypanosoma cruzi TcCLB.509575.50   Casein kinase II subunit beta, putative
Toxoplasma gondii TGME49_272400   casein kinase ii regulatory subunit protein
Toxoplasma gondii TGME49_268810   ck2 beta subunit
Theileria parva TP01_0881   casein kinase II beta chain, putative
Theileria parva TP02_0584   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_314920   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_239910   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_297610   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_014300   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_281580   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_198920   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_230170   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_092690   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_109300   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_319200   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_100900   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_167560   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_488390   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_334200   casein kinase II beta chain, putative
Trichomonas vaginalis TVAG_290850   casein kinase II beta chain, putative

Essentiality

PKNH_0901300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.2590 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.2590 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.2590 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.2590 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T01G9.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_T01G9.6 Caenorhabditis elegans larval arrest wormbase
CELE_T01G9.6 Caenorhabditis elegans larval lethal wormbase
CELE_T01G9.6 Caenorhabditis elegans slow growth wormbase
CELE_T01G9.6 Caenorhabditis elegans sterile wormbase
PBANKA_0943200 Plasmodium berghei Essential plasmo
TGME49_272400 Toxoplasma gondii Probably essential sidik
TGME49_268810 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens casein kinase 2, beta polypeptide Compounds References
Mus musculus casein kinase 2, beta polypeptide Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PKNH_0901300 (Plasmodium knowlesi), casein kinase II beta chain, putative
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