pI: 6.185 |
Length (AA): 393 |
MW (Da): 43039 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
89 | 376 | 1twf (C) | 4 | 262 | 25.00 | 0 | 1 | 0.92 | 0.33 |
82 | 374 | 4c2m (C) | 31 | 330 | 32.00 | 0 | 1 | 1.10705 | -0.22 |
101 | 368 | 4qjv (A) | 12 | 246 | 34.00 | 0 | 1 | 0.945534 | 0.29 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127819)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G60620 | RNA polymerase I subunit 43 |
Arabidopsis thaliana | AT1G60850 | DNA-directed RNA polymerase subunit AAC42 |
Babesia bovis | BBOV_III011540 | DNA-directed RNA polymerase, alpha subunit, N terminal domain containing protein |
Brugia malayi | Bm1_17950 | RNA polymerase Rpb3/Rpb11 dimerisation domain containing protein |
Candida albicans | CaO19.11048 | RNA polymerase III (C) subunit |
Candida albicans | CaO19.3564 | RNA polymerase III (C) subunit |
Caenorhabditis elegans | CELE_H43I07.2 | Protein RPAC-40 |
Cryptosporidium hominis | Chro.80042 | DNA-directed RNA polymerase I |
Cryptosporidium parvum | cgd8_300 | RNA polymerase III C5 subunit |
Dictyostelium discoideum | DDB_G0282339 | RNA polymerase I subunit |
Drosophila melanogaster | Dmel_CG3756 | CG3756 gene product from transcript CG3756-RA |
Echinococcus granulosus | EgrG_000860800 | DNA directed RNA polymerases I and III subunit |
Echinococcus multilocularis | EmuJ_000860800 | DNA directed RNA polymerases I and III subunit |
Giardia lamblia | GL50803_10055 | DNA-directed RNA polymerase subunit D |
Homo sapiens | ENSG00000171453 | polymerase (RNA) I polypeptide C, 30kDa |
Leishmania braziliensis | LbrM.19.0980 | DNA-directed RNA polymerase, alpha subunit, putative |
Leishmania donovani | LdBPK_190660.1 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Leishmania infantum | LinJ.19.0660 | DNA-directed RNA polymerase, alpha subunit, putative |
Leishmania major | LmjF.19.0660 | DNA-directed RNA polymerase, alpha subunit, putative |
Leishmania mexicana | LmxM.19.0660 | DNA-directed RNA polymerase, alpha subunit, putative |
Loa Loa (eye worm) | LOAG_00653 | hypothetical protein |
Mus musculus | ENSMUSG00000067148 | polymerase (RNA) I polypeptide C |
Neospora caninum | NCLIV_038790 | RNA polymerase II, related |
Oryza sativa | 4332531 | Os03g0295400 |
Onchocerca volvulus | OVOC6421 |
|
Plasmodium berghei | PBANKA_0905700 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Plasmodium falciparum | PF3D7_1143300 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Plasmodium knowlesi | PKNH_0941200 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Plasmodium vivax | PVX_092770 | DNA-directed RNA polymerase I, putative |
Plasmodium yoelii | PY01971 | DNA-directed RNA polymerases i and iii 40 kDa polypeptide |
Saccharomyces cerevisiae | YPR110C | DNA-directed RNA polymerase core subunit RPC40 |
Schistosoma japonicum | Sjp_0014050 | ko:K03027 DNA-directed RNA Polymerase III subunit C5, putative |
Schistosoma mansoni | Smp_004640 | DNA-directed RNA polymerase I |
Schmidtea mediterranea | mk4.005099.00 | |
Schmidtea mediterranea | mk4.001464.02 | |
Schmidtea mediterranea | mk4.000073.18 | |
Trypanosoma brucei gambiense | Tbg972.10.18770 | DNA-directed RNA polymerase, alpha subunit, putative |
Trypanosoma brucei | Tb927.10.15370 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Trypanosoma congolense | TcIL3000_10_13150 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Trypanosoma cruzi | TcCLB.511293.30 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Trypanosoma cruzi | TcCLB.506503.110 | DNA-directed RNA polymerases I and III subunit RPAC1, putative |
Toxoplasma gondii | TGME49_267390 | DNA-directed RNA polymerase I RPAC1 |
Theileria parva | TP02_0766 | DNA-directed RNA polymerase I, putative |
Trichomonas vaginalis | TVAG_016650 | DNA-directed RNA polymerase I/III subunits, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.15370 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.15370 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.15370 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.15370 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_H43I07.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H43I07.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H43I07.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_H43I07.2 | Caenorhabditis elegans | slow growth | wormbase |
YPR110C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_267390 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.