Detailed view for TcCLB.511423.110

Basic information

TDR Targets ID: 52758
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2246 | Length (AA): 425 | MW (Da): 46904 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
222 423 1kam (A) 1 165 24.00 0 0.9 0.45 0.57
225 295 1vlh (A) 2 67 18.00 0.000000031 0.27 0.39 -1.07
222 423 3mmx (F) 1 165 22.00 0.0000015 0.77 0.363294 0.82
225 296 1o6b (A) 4 70 12.00 0.11 0.19 0.297412 -0.66
227 350 1k4m (A) 7 119 30.00 0.18 0.36 0.436565 0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_135831)

Species Accession Gene Product
Arabidopsis thaliana AT2G01220   nucleotidyl transferase domain-containing protein
Arabidopsis thaliana AT3G27610   nucleotidylyl transferase domain-containing protein
Entamoeba histolytica EHI_045060   hypothetical protein, conserved
Leishmania braziliensis LbrM.20.4740   hypothetical protein, conserved
Leishmania donovani LdBPK_200570.1   hypothetical protein, conserved
Leishmania infantum LinJ.20.0570   hypothetical protein, conserved
Leishmania major LmjF.20.0500   hypothetical protein, conserved
Leishmania mexicana LmxM.20.0500   hypothetical protein, conserved
Oryza sativa 4325639   Os01g0691500
Trypanosoma cruzi TcCLB.507949.60   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511423.110   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus (strain N315) Probable nicotinate-nucleotide adenylyltransferase 189 aa 21.0% 200 aa Compounds References
Bacillus anthracis Nicotinate-nucleotide adenylyltransferase 189 aa 22.2% 198 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.511423.110 (Trypanosoma cruzi), hypothetical protein, conserved
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