pI: 9.7102 |
Length (AA): 818 |
MW (Da): 95272 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
32 | 814 | 4hzk (A) | 280 | 1057 | 10.00 | 0 | 0.93 | 0.926013 | 0.71 |
37 | 246 | 3ffz (A) | 741 | 930 | 29.00 | 0.033 | 0.04 | 0.106524 | 2.35 |
146 | 407 | 4z8n (A) | 166 | 420 | 16.00 | 0 | 0.51 | 0.379093 | -0.1 |
197 | 412 | 2ixr (A) | 55 | 284 | 12.00 | 0 | 0 | 0.286859 | -0.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126973)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G40090 | ATH family protein ABC2-like 9 |
Arabidopsis thaliana | AT5G24810 | ABC1 family protein |
Arabidopsis thaliana | AT3G07700 | ABC1 kinase |
Arabidopsis thaliana | AT1G65950 | protein kinase superfamily protein |
Babesia bovis | BBOV_III006120 | beta-lactamase family protein |
Brugia malayi | Bm1_24145 | ABC1 family protein |
Candida albicans | CaO19.11620 | likely ABC1 (chaperonin) family protein similar to mitochondrial S. cerevisiae YLR253W |
Candida albicans | CaO19.4144 | likely ABC1 (chaperonin) family protein similar to mitochondrial S. cerevisiae YLR253W |
Caenorhabditis elegans | CELE_D2023.6 | Protein D2023.6 |
Cryptosporidium hominis | Chro.50138 | hypothetical protein |
Cryptosporidium parvum | cgd5_2400 | conserved protein of possible plant or bacterial origin |
Dictyostelium discoideum | DDB_G0281799 | ABC1 family protein kinase |
Dictyostelium discoideum | DDB_G0284897 | ABC1 family protein kinase |
Drosophila melanogaster | Dmel_CG3608 | CG3608 gene product from transcript CG3608-RA |
Drosophila melanogaster | Dmel_CG7616 | CG7616 gene product from transcript CG7616-RA |
Echinococcus granulosus | EgrG_000283800 | ABC domain containing protein kinase |
Echinococcus multilocularis | EmuJ_000283800 | ABC domain containing protein kinase |
Homo sapiens | ENSG00000173137 | aarF domain containing kinase 5 |
Homo sapiens | ENSG00000063761 | aarF domain containing kinase 1 |
Leishmania braziliensis | LbrM.08.0240 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_080240.1 | ABC1 family, putative |
Leishmania infantum | LinJ.08.0240 | hypothetical protein, conserved |
Leishmania major | LmjF.08.0230 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.08.0230 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03784 | atypical/ABC1/ABC1-B protein kinase |
Mus musculus | ENSMUSG00000022550 | aarF domain containing kinase 5 |
Mus musculus | ENSMUSG00000021044 | aarF domain containing kinase 1 |
Neospora caninum | NCLIV_063390 | ABC1 family beta-lactamase, putative |
Neospora caninum | NCLIV_069430 | ABC1 family protein, related |
Oryza sativa | 9272392 | Os03g0698350 |
Oryza sativa | 4346513 | Os09g0250700 |
Oryza sativa | 4341968 | Os06g0701300 |
Oryza sativa | 9268625 | Os11g0549635 |
Onchocerca volvulus | OVOC12115 |
|
Plasmodium berghei | PBANKA_1028200 | atypical protein kinase, ABC-1 family, putative |
Plasmodium falciparum | PF3D7_1414500 | atypical protein kinase, ABC-1 family, putative |
Plasmodium knowlesi | PKNH_1343600 | atypical protein kinase, ABC-1 family, putative |
Plasmodium vivax | PVX_085725 | hypothetical protein, conserved |
Plasmodium yoelii | PY07155 | hypothetical protein |
Plasmodium yoelii | PY04349 | Arabidopsis thaliana At5g24810/F6A4_20 |
Saccharomyces cerevisiae | YLR253W | Mcp2p |
Schistosoma japonicum | Sjp_0027850 | ko:K08869 aarF domain-containing kinase, putative |
Schistosoma mansoni | Smp_098370.1 | ubiquinone biosynthesis protein aarf(E.coli)/abc1 |
Schistosoma mansoni | Smp_098370.2 | ubiquinone biosynthesis protein aarf(E.coli)/abc1 |
Schmidtea mediterranea | mk4.003145.04 | Ubiquinone biosynthesis protein aarf(E.coli)/abc1, putative |
Schmidtea mediterranea | mk4.003145.03 | Ubiquinone biosynthesis protein aarf(E.coli)/abc1, putative |
Schmidtea mediterranea | mk4.019928.00 | |
Schmidtea mediterranea | mk4.019928.01 | |
Schmidtea mediterranea | mk4.003145.02 | Ubiquinone biosynthesis protein aarf(E.coli)/abc1, putative |
Trypanosoma brucei gambiense | Tbg972.5.4800 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.5.3420 | ABC1 family, putative |
Trypanosoma brucei | Tb11.v5.0736 | ABC1 family, putative |
Trypanosoma congolense | TcIL3000_5_3880 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509777.90 | ABC1 family, putative |
Trypanosoma cruzi | TcCLB.509117.19 | ABC1 family, putative |
Toxoplasma gondii | TGME49_246600 | ABC1 family protein |
Toxoplasma gondii | TGME49_213620 | ABC1 family protein |
Theileria parva | TP02_0351 | ABC1 protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0714 | protein kinase, AarF |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3420 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3420 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3420 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3420 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_213620 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_246600 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_213620 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_246600 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Sus scrofa | Casein kinase I isoform alpha | 125 aa | 28.2% | 103 aa | Compounds | References |