Detailed view for PF3D7_1228100

Basic information

TDR Targets ID: 5324
Plasmodium falciparum, leucine-rich repeat protein
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.9998 | Length (AA): 447 | MW (Da): 52886 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14580   Leucine-rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 261 1h6u (A) 97 321 18.00 0 1 0.67 0.49
49 148 2bnh () 348 456 18.00 0 0.6 0.42 -1.16
17 112 1o6v (A) 248 339 38.00 0.22 1 0.720265 -0.74
17 234 4u09 (A) 107 305 34.00 0.018 1 0.664196 0.75
40 95 1xeu (A) 159 214 43.00 0.092 1 0.66478 -0.18
3 445 3vq1 (A) 58 525 16.00 0.0027 0.79 1.00961 1.31
304 443 4uos (A) 1 147 15.00 0.98 0.01 0.439707 -0.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Oocyst, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 8 hs, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_130092)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0275859   leucine-rich repeat-containing protein
Drosophila melanogaster Dmel_CG14620   touch insensitive larva B
Echinococcus granulosus EgrG_000462300   leucine rich repeat containing protein 6
Echinococcus multilocularis EmuJ_000462300   leucine rich repeat containing protein 6
Giardia lamblia GL50803_3408   U2 small nuclear ribonucleoprotein A, putative
Homo sapiens ENSG00000129295   leucine rich repeat containing 6
Leishmania braziliensis LbrM.29.2190   hypothetical protein, conserved
Leishmania donovani LdBPK_292320.1   leucine-rich repeat-containing protein
Leishmania infantum LinJ.29.2320   hypothetical protein, conserved
Leishmania major LmjF.29.2210   hypothetical protein, conserved
Leishmania mexicana LmxM.08_29.2210   hypothetical protein, conserved
Mus musculus ENSMUSG00000022375   leucine rich repeat containing 6 (testis)
Neospora caninum NCLIV_015890   leucine rich repeat protein, putative
Plasmodium berghei PBANKA_1442800   leucine-rich repeat protein
Plasmodium falciparum PF3D7_1228100   leucine-rich repeat protein
Plasmodium knowlesi PKNH_1447500   leucine-rich repeat protein
Plasmodium vivax PVX_124035   hypothetical protein, conserved
Plasmodium yoelii PY04002   hypothetical protein
Plasmodium yoelii PY04003   Leucine Rich Repeat, putative
Schistosoma japonicum Sjp_0304580   Leucine-rich repeat-containing protein 6, putative
Schistosoma mansoni Smp_120380   testis specific leucine rich repeat protein
Schmidtea mediterranea mk4.001326.03   Protein tilB
Schmidtea mediterranea mk4.001326.04  
Trypanosoma brucei gambiense Tbg972.3.5290   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.3.5330   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.4730   leucine-rich repeat-containing protein
Trypanosoma brucei Tb927.3.4770   leucine-rich repeat-containing protein
Trypanosoma congolense TcIL3000_0_42660   leucine-rich repeat-containing protein
Trypanosoma cruzi TcCLB.503671.30   leucine-rich repeat-containing protein
Trypanosoma cruzi TcCLB.508153.30   leucine-rich repeat-containing protein
Toxoplasma gondii TGME49_239110   leucine rich repeat-containing protein
Trichomonas vaginalis TVAG_298070   B7 leucine rich protein, putative

Essentiality

PF3D7_1228100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1442800 Plasmodium berghei Dispensable plasmo
TGME49_239110 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1228100 (Plasmodium falciparum), leucine-rich repeat protein
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