Detailed view for TcCLB.509161.20

Basic information

TDR Targets ID: 53324
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.4381 | Length (AA): 226 | MW (Da): 26237 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01479   S4 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0019843   rRNA binding  
GO:0003723   RNA binding  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
149 213 2cqj (A) 104 168 46.00 0 1 0.84 -1.32
69 210 4kzy (J) 22 164 24.00 0 1 0.989219 -0.32
74 207 5wxm (A) 28 162 39.00 0 1 1.17382 -1.02
147 211 2cqj (A) 102 166 48.00 0 1 0.920911 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128165)

Species Accession Gene Product
Arabidopsis thaliana AT5G15750   alpha-L RNA-binding motif/ribosomal protein S4 family protein
Babesia bovis BBOV_IV002230   U3 small nucleolar ribonucleoprotein protein IMP3-like protein
Brugia malayi Bm1_03935   40S ribosomal protein S4-like
Candida albicans CaO19.7488   similar to S. cerevisiae IMP3 (YHR148W) component of U3 snoRNP involved in pre-18S rRNA processing
Caenorhabditis elegans CELE_C48B6.2   Protein C48B6.2
Cryptosporidium hominis Chro.70129   S4 domain
Cryptosporidium parvum cgd7_1040   Imp3p-like 40S ribosomal protein S9. S4 RNA binding domain
Dictyostelium discoideum DDB_G0278983   U3 small nucleolar ribonucleoprotein protein
Drosophila melanogaster Dmel_CG4866   CG4866 gene product from transcript CG4866-RA
Echinococcus granulosus EgrG_000214200   U3 small nucleolar ribonucleoprotein
Entamoeba histolytica EHI_146820   U3 small nucleolar ribonucleoprotein subunit, putative
Entamoeba histolytica EHI_184000   U3 small nucleolar ribonucleoprotein subunit, putative
Entamoeba histolytica EHI_035170   U3 small nucleolar ribonucleoprotein subunit, putative
Echinococcus multilocularis EmuJ_000214200   U3 small nucleolar ribonucleoprotein
Giardia lamblia GL50803_11319   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Homo sapiens ENSG00000177971   IMP3, U3 small nucleolar ribonucleoprotein
Leishmania braziliensis LbrM.32.0770   hypothetical protein, conserved
Leishmania donovani LdBPK_320720.1   hypothetical protein, conserved
Leishmania infantum LinJ.32.0720   hypothetical protein, conserved
Leishmania major LmjF.32.0690   hypothetical protein, conserved
Leishmania mexicana LmxM.31.0690   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05536   hypothetical protein
Mus musculus ENSMUSG00000032288   IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
Neospora caninum NCLIV_003710   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Oryza sativa 4337293   Os04g0662100
Plasmodium berghei PBANKA_1324900   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Plasmodium falciparum PF3D7_1461200   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Plasmodium knowlesi PKNH_1220500   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Plasmodium vivax PVX_117395   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Plasmodium yoelii PY04143   S4 domain, putative
Saccharomyces cerevisiae YHR148W   Imp3p
Schistosoma japonicum Sjp_0080830   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Schistosoma mansoni Smp_102820   ribosomal protein related
Schmidtea mediterranea mk4.000244.07   Putative 40S ribosomal protein S4-like
Trypanosoma brucei gambiense Tbg972.11.15560   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Trypanosoma brucei Tb927.11.13930   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Trypanosoma congolense TcIL3000.11.14300   U3 small nucleolar ribonucleoprotein protein IMP3, putative
Trypanosoma cruzi TcCLB.509161.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.504643.20   hypothetical protein, conserved
Toxoplasma gondii TGME49_209430   40S ribosomal protein S4, putative
Theileria parva TP03_0429   40S ribosomal protein S4, putative
Trichomonas vaginalis TVAG_221740   30S 40S ribosomal protein, putative

Essentiality

TcCLB.509161.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.5500 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.5500 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.5500 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.5500 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C48B6.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C48B6.2 Caenorhabditis elegans larval arrest wormbase
CELE_C48B6.2 Caenorhabditis elegans larval lethal wormbase
CELE_C48B6.2 Caenorhabditis elegans slow growth wormbase
CELE_C48B6.2 Caenorhabditis elegans sterile wormbase
YHR148W Saccharomyces cerevisiae inviable yeastgenome
TGME49_209430 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509161.20 (Trypanosoma cruzi), hypothetical protein, conserved
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