Detailed view for TcCLB.509539.30

Basic information

TDR Targets ID: 53616
Trypanosoma cruzi, fatty acid elongase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.1913 | Length (AA): 253 | MW (Da): 29660 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01151   GNS1/SUR4 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126732)

Species Accession Gene Product
Arabidopsis thaliana AT3G06460   membrane-associated elongase-like protein
Arabidopsis thaliana AT3G06470   GNS1/SUR4 membrane protein family
Candida albicans CaO19.6343   one of three potential fatty acid elongase genes
Candida albicans CaO19.13699   one of three potential fatty acid elongase genes
Caenorhabditis elegans CELE_F56H11.3   Protein ELO-7, isoform B
Dictyostelium discoideum DDB_G0271066   hypothetical protein
Dictyostelium discoideum DDB_G0270312   GNS1/SUR4 family protein
Drosophila melanogaster Dmel_CG31522   CG31522 gene product from transcript CG31522-RF
Drosophila melanogaster Dmel_CG2781   CG2781 gene product from transcript CG2781-RA
Drosophila melanogaster Dmel_CG32072   Elongase 68alpha
Drosophila melanogaster Dmel_CG11801   Elongase 68beta
Echinococcus granulosus EgrG_000347100   elongation of very long chain fatty acids
Echinococcus multilocularis EmuJ_000347100   elongation of very long chain fatty acids
Homo sapiens ENSG00000118402   ELOVL fatty acid elongase 4
Homo sapiens ENSG00000197977   ELOVL fatty acid elongase 2
Homo sapiens ENSG00000164181   ELOVL fatty acid elongase 7
Leishmania braziliensis LbrM.05.1160   fatty acid elongase, putative
Leishmania braziliensis LbrM.32.1310   long chain polyunsaturated fatty acid elongation enzyme-like protein
Leishmania donovani LdBPK_051160.1   elongation of very long chain fatty acids protein, putative
Leishmania donovani LdBPK_321220.1   long chain polyunsaturated fatty acid elongation enzyme-like protein
Leishmania infantum LinJ.05.1160   fatty acid elongase, putative
Leishmania infantum LinJ.32.1220   long chain polyunsaturated fatty acid elongation enzyme-like protein
Leishmania major LmjF.32.1160   long chain polyunsaturated fatty acid elongation enzyme-like protein
Leishmania major LmjF.05.1170   fatty acid elongase, putative
Leishmania mexicana LmxM.05.1170   elongation of very long chain fatty acids protein, putative
Leishmania mexicana LmxM.31.1160   long chain polyunsaturated fatty acid elongation enzyme-like protein
Mus musculus ENSMUSG00000021696   ELOVL family member 7, elongation of long chain fatty acids (yeast)
Mus musculus ENSMUSG00000021364   elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
Mus musculus ENSMUSG00000032262   elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Neospora caninum NCLIV_017540   elongation of very long chain fatty acids 4 protein, putative
Plasmodium berghei PBANKA_0104700   long chain polyunsaturated fatty acid elongation enzyme, putative
Plasmodium falciparum PF3D7_0605900   long chain polyunsaturated fatty acid elongation enzyme, putative
Plasmodium knowlesi PKNH_1144300   long chain polyunsaturated fatty acid elongation enzyme, putative
Plasmodium vivax PVX_113465   long chain polyunsaturated fatty acid elongation enzyme, putative
Plasmodium yoelii PY00625   hypothetical protein
Saccharomyces cerevisiae YCR034W   fatty acid elongase ELO2
Schistosoma japonicum Sjp_0095000   Elongation of very long chain fatty acids protein AAEL008004, putative
Schistosoma japonicum Sjp_0062200   ko:K10249 elongation of very long chain fatty acids protein 4, putative
Schistosoma japonicum Sjp_0314970   Elongation of very long chain fatty acids protein 7, putative
Schistosoma japonicum Sjp_0044090   ko:K10250 elongation of very long chain fatty acids protein 7, putative
Schistosoma mansoni Smp_010770.2   elongation of fatty acids protein 1
Schistosoma mansoni Smp_051810   elongation of fatty acids protein 1
Schistosoma mansoni Smp_010770.1   fatty acid acyl transferase-related
Schmidtea mediterranea mk4.004143.00  
Schmidtea mediterranea mk4.005022.00  
Schmidtea mediterranea mk4.009946.01   Elongation of very long chain fatty acids protein 4
Schmidtea mediterranea mk4.054857.00   Elongation of fatty acids protein 1
Schmidtea mediterranea mk4.016012.00  
Schmidtea mediterranea mk4.006666.02   Elongation of fatty acids protein 1
Schmidtea mediterranea mk4.005022.01  
Schmidtea mediterranea mk4.004734.03  
Schmidtea mediterranea mk4.009918.00   Elongation of very long chain fatty acids protein 4
Schmidtea mediterranea mk4.006478.00  
Trypanosoma brucei gambiense Tbg972.5.6070   elongation of very long chain fatty acids protein, putative
Trypanosoma brucei Tb05.5K5.170   elongation of very long chain fatty acids protein, putative
Trypanosoma brucei Tb927.5.4530   Long chain fatty acyl elongase
Trypanosoma congolense TcIL3000_5_5220   elongation of very long chain fatty acids protein, putative
Trypanosoma cruzi TcCLB.509539.30   fatty acid elongase, putative
Trypanosoma cruzi TcCLB.506717.10   fatty acid elongase, putative
Toxoplasma gondii TGME49_242380   fatty acid elongase

Essentiality

TcCLB.509539.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.4530 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.4530 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.4530 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.5.4530 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0104700 Plasmodium berghei Dispensable plasmo
TGME49_242380 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ELOVL fatty acid elongase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509539.30 (Trypanosoma cruzi), fatty acid elongase, putative
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