pI: 9.1581 |
Length (AA): 335 |
MW (Da): 39975 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 332 | 5xvu (A) | 12 | 332 | 96.00 | 0 | 1 | 2.14671 | -1.47 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126901)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G50000 | casein kinase II, alpha chain 2 |
Arabidopsis thaliana | AT2G23070 | casein kinase 2, alpha polypeptide |
Arabidopsis thaliana | AT5G67380 | casein kinase II subunit alpha-1 |
Arabidopsis thaliana | AT2G23080 | casein kinase II alpha chain 3 |
Babesia bovis | BBOV_III007790 | casein kinase II, alpha chain (CK II) |
Brugia malayi | Bm1_49830 | Casein kinase II, alpha chain |
Candida albicans | CaO19.11014 | Casein kinase II alpha' subunit |
Candida albicans | CaO19.3530 | Casein kinase II alpha' subunit |
Candida albicans | CaO19.7652 | likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II |
Caenorhabditis elegans | CELE_B0205.7 | Protein KIN-3 |
Cryptosporidium hominis | Chro.60083 | protein kinase domain |
Cryptosporidium parvum | cgd6_620 | casein kinase II, alpha subunit, putative |
Dictyostelium discoideum | DDB_G0276885 | CK2 family protein kinase |
Drosophila melanogaster | Dmel_CG17520 | casein kinase IIalpha |
Echinococcus granulosus | EgrG_000457900 | casein kinase ii subunit alpha |
Entamoeba histolytica | EHI_038670 | protein kinase domain containing protein |
Entamoeba histolytica | EHI_006800 | casein kinase, putative |
Echinococcus multilocularis | EmuJ_000457900 | casein kinase ii subunit alpha |
Giardia lamblia | GL50803_27520 | Kinase, CMGC CK2 |
Homo sapiens | ENSG00000254598 | casein kinase 2, alpha 3 polypeptide |
Homo sapiens | ENSG00000070770 | casein kinase 2, alpha prime polypeptide |
Homo sapiens | ENSG00000101266 | casein kinase 2, alpha 1 polypeptide |
Leishmania braziliensis | LbrM.34.1630 | casein kinase II, putative |
Leishmania donovani | LdBPK_351720.1 | casein kinase II, putative |
Leishmania infantum | LinJ.35.1720 | casein kinase II, putative |
Leishmania major | LmjF.35.1730 | casein kinase II, putative |
Leishmania mexicana | LmxM.34.1730 | casein kinase II, putative |
Loa Loa (eye worm) | LOAG_03081 | CMGC/CK2 protein kinase |
Mus musculus | ENSMUSG00000046707 | casein kinase 2, alpha prime polypeptide |
Mus musculus | ENSMUSG00000074698 | casein kinase 2, alpha 1 polypeptide |
Neospora caninum | NCLIV_024840 | hypothetical protein |
Oryza sativa | 9271280 | Os03g0762000 |
Oryza sativa | 4332003 | Os03g0207300 |
Oryza sativa | 4342248 | Os07g0114400 |
Plasmodium berghei | PBANKA_0938600 | casein kinase 2, alpha subunit |
Plasmodium falciparum | PF3D7_1108400 | casein kinase 2, alpha subunit |
Plasmodium knowlesi | PKNH_0906000 | casein kinase 2, alpha subunit, putative |
Plasmodium vivax | PVX_091095 | casein kinase 2, alpha subunit, putative |
Plasmodium vivax | PVX_252300 | unspecified product |
Plasmodium yoelii | PY05048 | Protein kinase domain |
Saccharomyces cerevisiae | YIL035C | casein kinase 2 catalytic subunit CKA1 |
Saccharomyces cerevisiae | YOR061W | casein kinase 2 catalytic subunit CKA2 |
Schistosoma japonicum | Sjp_0036170 | ko:K03097 casein kinase 2, alpha polypeptide, putative |
Schistosoma mansoni | Smp_099030 | protein kinase |
Schmidtea mediterranea | mk4.000166.08 | Casein kinase II subunit alpha |
Schmidtea mediterranea | mk4.000424.04 | Casein kinase II subunit alpha |
Trypanosoma brucei gambiense | Tbg972.9.9070 | casein kinase II, putative |
Trypanosoma brucei | Tb927.9.14430 | Casein kinase II |
Trypanosoma congolense | TcIL3000_0_32020 | casein kinase II, putative |
Trypanosoma cruzi | TcCLB.510761.60 | casein kinase II, putative |
Toxoplasma gondii | TGME49_263070 | CMGC kinase, CK2 family |
Theileria parva | TP04_0659 | casein kinase II, alpha chain |
Trichomonas vaginalis | TVAG_305130 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_544210 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_485710 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_064190 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_172040 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_340780 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_135230 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.4890 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.4890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.4890 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.211.4890 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_B0205.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0205.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_B0205.7 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0938600 | Plasmodium berghei | Essential | plasmo |
TGME49_263070 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | Compounds | References |
Mus musculus | casein kinase 2, alpha prime polypeptide | Compounds | References |
Zea mays | Casein kinase II alpha | Compounds | References |
Homo sapiens | casein kinase 2, alpha 1 polypeptide | Compounds | References |
Homo sapiens | casein kinase 2, alpha prime polypeptide | Compounds | References |
Mus musculus | casein kinase 2, alpha 1 polypeptide | Compounds | References |
Homo sapiens | casein kinase 2, alpha 3 polypeptide | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Plasmodium falciparum | protein kinase 5 | 288 aa | 32.4% | 299 aa | Compounds | References |
Plasmodium falciparum | protein kinase 6 | 305 aa | 32.4% | 312 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 32.3% | 303 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 33.6% | 301 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 32.0% | 300 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 32.4% | 299 aa | Compounds | References |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 311 aa | 32.3% | 303 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 31.5% | 168 aa | Compounds | References |