Detailed view for PY06259

Basic information

TDR Targets ID: 536802
Plasmodium yoelii, histone deacetylase/AcuC/AphA family protein, putative
Source Database / ID: 

pI: 8.8077 | Length (AA): 461 | MW (Da): 54447 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00850   Histone deacetylase domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 252 5dkt (A) 125 358 34.00 0.61 0.29 0.323792 1.57
88 434 5g0i (A) 374 747 18.00 0 1 0.890011 0.15
142 433 4a69 (A) 2 299 24.00 0 1 0.790206 -0.35
146 456 4bz7 (B) 4 367 23.00 0 1 0.81542 -0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129938)

Species Accession Gene Product
Arabidopsis thaliana AT5G26040   histone deacetylase 2
Brugia malayi Bm1_15905   histone deacetylase 11
Caenorhabditis elegans CELE_C35A5.9   Protein HDA-11
Drosophila melanogaster Dmel_CG31119   Histone deacetylase X
Homo sapiens ENSG00000163517   histone deacetylase 11
Loa Loa (eye worm) LOAG_14762   hypothetical protein
Loa Loa (eye worm) LOAG_11607   histone deacetylase 11
Mus musculus ENSMUSG00000034245   histone deacetylase 11
Neospora caninum NCLIV_028460   hypothetical protein
Oryza sativa 4341352   Os06g0571100
Plasmodium berghei PBANKA_1106200   histone deacetylase, putative
Plasmodium knowlesi PKNH_1027000   histone deacetylase, putative
Plasmodium vivax PVX_097890   histone deacetylase, putative
Plasmodium yoelii PY06259   histone deacetylase/AcuC/AphA family protein, putative
Schmidtea mediterranea mk4.000002.37  
Toxoplasma gondii TGME49_257790   histone deacetylase HDAC4

Essentiality

PY06259 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_257790 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens histone deacetylase 11 Compounds References
Mus musculus histone deacetylase 11 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PY06259 (Plasmodium yoelii), histone deacetylase/AcuC/AphA family protein, putative
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